Results 111 to 120 of about 25,065,433 (389)

PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program

Nature, 2022
M. Hashimoto, K. Araki, M. Cardenas, Peng Li, R. Jadhav, H. Kissick, W. Hudson, D. McGuire, Rebecca C. Obeng, A. Wieland, Judong Lee, Daniel T. McManus, J. Ross, S. Im, JungHwa Lee, Jian-Xin Lin, B. Hu, E. West, Christopher D. Scharer, G. Freeman, A. Sharpe, S. Ramalingam, A. Pellerin, V. Teichgräber, W. Greenleaf, C. Klein, J. Goronzy, P. Umaña, W. Leonard, Kendall A. Smith, R. Ahmed   +30 more
semanticscholar   +1 more source

CD4 memory T cells divide poorly in response to antigen because of their cytokine profile [PDF]

, 2008
Immunological memory is a hallmark of adaptive immunity, and understanding T cell memory will be central to the development of effective cell-mediated vaccines. The characteristics and functions of CD4 memory cells have not been well defined.
A. McKee, Anthony, Antia, Blattman, Crawford, D'Souza, F. Crawford, Glomski, Homann, Huseby, J. Kappler, J. White, Jenkins, Khanna, Kriss, London, M. K. L. MacLeod, Marzo, Merica, Moon, Moulton, Oxenius, P. Marrack, Schiemann, Schluns, Surh, Tewari, Tibbetts, Varga, Whitmire, Whitmire, Whitmire, Williams, Yin   +33 more
core   +2 more sources

Residues R177 and S178 of the human Na+/H+ antiporter NHA2 are involved in its inhibition by the flavonoid phloretin

FEBS Letters, Volume 599, Issue 6, Page 901-911, March 2025.
The human Na+/H+ antiporter NHA2 transports Na+ or Li+ in exchange for protons across cell membranes, and its dysfunction results in various pathologies, e.g., fertility disorders, hypertension, or diabetes. This work provides the molecular characterization of interactions of NHA2 with its specific inhibitor phloretin, which can be helpful for the ...
Olga Zimmermannova, Martin Kubeš, Tereza Przeczková, Gal Masrati   +3 more
wiley   +1 more source

TREATMENT OF CHRONIC CHAGASIC PATIENTS: IS KILLING THE PARASITE THE ONLY OPTION?

European Medical Journal Cardiology, 2018
Chagas disease is a tropical illness characterised by arrhythmias, heart failure, and eventually death. In approximately 10–30% of patients, chronic disease appears 10–30 years after infection onset.
Héctor O. Rodríguez-Angulo
doaj  

Prenatal arsenic exposure interferes in postnatal immunocompetence despite an absence of ongoing arsenic exposure

Journal of Immunotoxicology, 2020
Arsenic (As) readily crosses the placenta and exposure of the fetus may cause adverse consequences later in life, including immunomodulation. In the current study, the question was asked how the immune repertoire might respond in postnatal life when ...
Mainak Chakraborty, Moumita Bhaumik
doaj   +1 more source

IL-2/anti-IL-2 complex attenuates renal ischemia-reperfusion injury through expansion of regulatory T cells.

Journal of the American Society of Nephrology, 2013
Regulatory T cells (Tregs) can suppress immunologic damage in renal ischemia-reperfusion injury (IRI), but the isolation and ex vivo expansion of these cells for clinical application remains challenging.
Myung-Gyu Kim, T. Koo, Ji-Jing Yan, Eunwon Lee, K. Han, J. Jeong, H. Ro, B. Kim, S. Jo, K. Oh, C. Surh, C. Ahn, Jaeseok Yang   +12 more
semanticscholar   +1 more source

CD28 and T cell antigen receptor signal transduction coordinately regulate interleukin 2 gene expression in response to superantigen stimulation. [PDF]

, 1992
Activation of an immune response requires intercellular contact between T lymphocytes and antigen-presenting cells (APC). Interaction of the T cell antigen receptor (TCR) with antigen in the context of major histocompatibility molecules mediates signal ...
Fraser, JD, Newton, ME, Weiss, A
core  

Eosinophil and T Cell Markers Predict Functional Decline in COPD Patients [PDF]

, 2009
BACKGROUND. The major marker utilized to monitor COPD patients is forced expiratory volume in one second (FEV1). However, asingle measurement of FEV1 cannot reliably predict subsequent decline.
A Papi, AK Sullivan, AT Society, B Barcelo, B Meshi, BH Nelson, C Fletcher, CS Robbins, CS Robbins, DL Mueller, DW Perng, F Mor, G Rohde, GJ de Bree, J Chang, J Chang, JL Hankinson, L Lintomen, L Taraseviciene-Stewart, L Van Parijs, L Van Parijs, M Decramer, M Miller, M Saetta, M Saetta, MD Roth, N Tzanakis, NR Anthonisen, P Glader, PC Doherty, PD Ponath, PD Ponath, PJ Barnes, PT King, RO Crapo, RW Vandivier, S Chakrabarti, S Hodge, S Hodge, S Hodge, S Wei, T Seemungal, TC O'Shaughnessy, V Bocchino   +43 more
core   +4 more sources

Cytosolic‐enhanced dark Epac‐based FRET sensors allow for intracellular cAMP detection in live cells via FLIM

FEBS Letters, Volume 599, Issue 7, Page 1075-1085, April 2025.
We describe a novel set of Epac‐based FRET‐FLIM biosensors with improved fully cytosolic distribution, achieved without compromising the state‐of‐the‐art performance of our original designs, for detecting cAMP dynamics in real time in live cells with high precision and reliability.
Giulia Zanetti, Jeffrey B. Klarenbeek, Kees Jalink   +2 more
wiley   +1 more source

DEVELOPMENT OF A REAL-TIME RT-PCR-BASED TEST PANEL FOR ASSESSMENT OF CYTOKINE PROFILE IN MONONUCLEAR CELLS FROM BLOOD AND SYNOVIAL FLUID IN RHEUMATOID ARTHRITIS

Медицинская иммунология, 2014
. An imbalance between pro- and anti-inflammatory cytokine synthesis plays a crucial role in pathogenesis of rheumatoid arthritis (RA), including erosive joint lesions.
D. Yu. Trofimov, O. V. Burmenskaya, E. I. Bateneva, L. P. Alexeev, E. L. Nasonov, E. N. Alexandrova, A. A. Novikov   +6 more
doaj   +1 more source