Results 121 to 130 of about 25,065,433 (389)

A rationally-engineered IL-2 improves the antitumor effect of anti-CD20 therapy

OncoImmunology, 2020
Anti-CD20 treatment represents a therapeutic benefit for patients with B-cell lymphomas, although more efficient therapies are needed for refractory or relapsing patients. Among them, the combination of anti-CD20 and IL-2 that induces T cell response has
Ana Victoria Casadesús, Claire Deligne, Béré Kadjdiatou Diallo, Katya Sosa, Nathalie Josseaume, Circe Mesa, Kalet León, Tays Hernández, Jean-Luc Teillaud   +8 more
doaj   +1 more source

A Global and Local Structure-Based Method for Predicting Binary Protein-Protein Interaction Partners: Proof of Principle and Feasibility [PDF]

arXiv, 2015
We report a 3D structure-based method of predicting protein-protein interaction partners. It involves screening for pairs of tetrahedra representing interacting amino acids at the interface of the protein-protein complex, with one tetrahedron on each protomer.
arxiv  

Diphthamide synthesis is linked to the eEF2‐client chaperone machinery

FEBS Letters, Volume 599, Issue 9, Page 1260-1268, May 2025.
The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr, Klaus Mayer, Raffael Schaffrath, Johannes Buchner, Ulrich Brinkmann   +4 more
wiley   +1 more source

75. Evaluating the Long-term Outcomes Associated with the Use of Fresh Frozen Allograft Cartilage in Cosmetic and Reconstructive Rhinoplasty Procedures: A Prospective Controlled Clinical Trial

Plastic and Reconstructive Surgery, Global Open, 2023
Rou Wan, MD, Joshua P. Weissman, BBA, Chitang J. Joshi, MD, Genevieve Putnam, BS, Tokoya Williams, MD, Robert D. Galiano, MD, FACS   +5 more
doaj   +1 more source

FUNCTIONAL POLYMORPHISM OF THE PRO-INFLAMMATORY CYTOKINE GENES IN PULMONARY TUBERCULOSIS

Медицинская иммунология, 2019
In the present time, incidence of pulmonary tuberculosis (TB) becomes broader, due to spreading resistance of Mycobacterium tuberculosis (MBT) to anti-tuberculosis drugs and infection with highly virulent strains of M. tuberculosis.
E. G. Churina, O. I. Urazova, V. V. Novitsky, A. V. Sitnikova, S. E. Barmina   +4 more
doaj   +1 more source

TCB2, a new anti-human interleukin-2 antibody, facilitates heterodimeric IL-2 receptor signaling and improves anti-tumor immunity

OncoImmunology, 2020
IL-2 is a pleiotropic cytokine that plays an essential role in the survival, expansion, and function of CD8 T cells, regulatory T cells (Tregs), and natural killer (NK) cells.
Jun-Young Lee, Eunjin Lee, Sung-Wook Hong, Daeun Kim, O. Eunju, Jonathan Sprent, Sin-Hyeog Im, You Jeong Lee, Charles D. Surh   +8 more
doaj   +1 more source

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells

Journal of Experimental Medicine, 1996
While interactions between CD28 and members of the B7 family costimulate and enhance T cell responses, recent evidence indicates that the CD28 homologue CTLA-4 plays a downregulatory role.
M. Krummel, J. Allison
semanticscholar   +1 more source

Interleukin -2 ( Il-2 ) and Gamma Interferon ( Ifn ? ) of Lymphocyte Culture Supernatant in Iron Deficiency Anemia Patients with Infection [PDF]

, 2010
Iron is an essential nutrient for every living cells because of it role as molecule fortransport of oxygen, as well as DNA synthesis through synthesis of ribonucleotidereductase.
Bakta, I. M. (I), D, A. S. (AAG), Suata, K. (Ketut), Suega, K. (Ketut)   +3 more
core  

The [2Fe‐2S] cluster of mitochondrial outer membrane protein mitoNEET has an O2‐regulated nitric oxide access tunnel

FEBS Letters, Volume 599, Issue 7, Page 952-970, April 2025.
The mitochondrial outer membrane iron–sulphur ([Fe‐S]) protein mitoNEET is a target of the type‐2 diabetes drug pioglitazone. Its unknown molecular function is linked to respiratory complex activity and mitochondrial function. We discovered that O2 protects the mitoNEET [2Fe‐2S] cluster against NO oxidation and desensitization towards reduction by H2S.
Thao Nghi Hoang, Meritxell Wu‐Lu, Alberto Collauto, Peter‐Leon Hagedoorn, Madalina Alexandru, Maike Henschel, Shahram Kordasti, Maria Andrea Mroginski, Maxie M. Roessler, Kourosh H. Ebrahimi   +9 more
wiley   +1 more source

44. A Wireless Intramuscular Near-infrared Spectroscopy Device Detects Muscle Oxygenation Changes in Porcine Model of Lower Extremity Compartment Syndrome

Plastic and Reconstructive Surgery, Global Open, 2022
Amanda Westman, PhD, Hexia Guo, MS, Yameng Xu, MS, Wubin Bai, PhD, Wei Ouyang, PhD, William Moritz, MD, Lauren Jacobson, MD, Yang Weng, MS, Hao Zang, MS, Changsheng Wu, PhD, Ziying Hu, PhD, Shuo Li, PhD, Di Lu, PhD, Hany Arafa, MS, Matthew MacEwan, MD, PhD, Lauren Tatman, MD, John Rogers, PhD, Mitchell Pet, MD   +17 more
doaj   +1 more source