(1) A Concise Treatise on Reinforced Concrete (2) Concrete-Steel Construction (3) Il Cemento Armato e la sua applicazione practica (4) Le prove dei materiali da costruzione e le costruzioni in Cemento Armato [PDF]
, 1910 T. H. B.
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Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
FEBS Letters, Volume 599, Issue 8, Page 1094-1112, April 2025.The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher +6 more
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A reaction-diffusion model for relapsing-remitting multiple sclerosis with a treatment term [PDF]
arXivWe present a mathematical study for the development of multiple sclerosis based on a reaction-diffusion system. The model describes interactions among different populations of human cells, motion of immune cells stimulated by cytokines, consumption of myelin sheath due to anomalously activated lymphocytes and its restoration by oligodendrocytes ...
arxiv
Quaderni di Storia della Scienza e della Medicina. Universita degli Studi de Ferrara. 1963–1965. Il Fenomeno Paracelso, by R. BLASER, 1963, pp. 37, illustr. Giovanni Pico della Mirandola nei suoi rapporti di amicizia con Gerolamo Savonarola, by P. Rocca, 1964, pp. 29, 2 illus. Arcangelo Piccolomini Ferrarese (1525–1586) e la sua importanza nell'anatomia Postvesaliana, by F. Perro, 1965, pp. 35, frontis. [PDF]
, 1966 Walter Pagel
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Both integrated and differential regulation of components of the IL-2/IL-2 receptor system
Cytokine & Growth Factor Reviews, 2006 Interleukin-2 was discovered in 1976 as a T-cell growth factor. It was the first type I cytokine cloned and the first for which a receptor component was cloned. Its importance includes its multiple actions, therapeutic potential, and lessons for receptor biology, with three components differentially combining to form high, intermediate, and low ...
Warren J. Leonard +2 more
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FEBS Letters, Volume 599, Issue 7, Page 971-988, April 2025.We present the first solution structure of the Ca2+‐depleted LETM1 F‐EF‐hand through a D676A/N678A Ca2+ binding‐deficient mutant, revealing a closed hydrophobic cleft caused by a unique F1‐helix pivot. The apo LETM1 F‐EF‐hand exhibits regiospecific hot and cold unfolding, sensitivity to physiological pH changes and potential for promiscuous heterotypic
Qi‐Tong Lin +2 more
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IL-2 regulation of soluble IL-2 receptor levels following thermal injury
Clinical and Experimental Immunology, 1992 SUMMARYIn the immunosuppresscd burn patient serum levels of both IL-2 and a soluble form of IL-2 receptor alpha (sIL-2Rα) are significantly elevated. Strikingly, the production of these markers by the in vitro activated patients' cells is decreased. This study examines the role of IL-2 in the decreased production of the sIL-2Rαin vitro in patients with
S. Lalani +4 more
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Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice. [PDF]
, 2014 Aging is a contributing factor in cancer occurrence. We recently demonstrated that systemic immunotherapy (IT) administration in aged, but not young, mice resulted in induction of rapid and lethal cytokine storm.
Blazar, Bruce +18 more
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Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones
FEBS Letters, Volume 599, Issue 9, Page 1269-1284, May 2025.Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
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The development of anti-interleukin-2 antibodies in patients treated with recombinant human interleukin-2 (IL-2) [PDF]
, 1986 Mark Allegretta +7 more
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