Results 281 to 290 of about 25,065,433 (389)

Human IL-2 Mutein with Higher Antitumor Efficacy Than Wild Type IL-2

Journal of Immunology, 2013
T. Carmenate, Ana R. Pacios, M. Enamorado, E. Moreno, Karina García-Martínez, Dasha Fuente, K. Leon   +6 more
semanticscholar   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Acidity suppresses CD8 + T-cell function by perturbing IL-2, mTORC1, and c-Myc signaling. [PDF]

EMBO J
Vuillefroy de Silly R, Pericou L, Seijo B, Crespo I, Irving M.   +4 more
europepmc   +1 more source

Presence of a p70 IL-2-binding peptide on leukemic cells from various hemopoietic lineages. [PDF]

, 1989
M Allouche, Yasmina Sahraoui, Yvette Augery-Bourget, Yuji Ohashi, Kazuo Sugamura, C Jasmin, Vassilis Georgoulias   +6 more
openalex   +1 more source

Hijacking the BAF complex: the mechanistic interplay of ARID1A and EWS::FLI1 in Ewing sarcoma

Molecular Oncology, Volume 19, Issue 4, Page 961-964, April 2025.
Ewing sarcoma is driven by the EWS::FLI1 fusion protein, which disrupts gene expression by hijacking the BAF complex via ARID1A. ARID1A's ability to form biomolecular condensates is crucial for tumor growth, making it a potential therapeutic target. However, targeting these transient condensates is challenging, requiring further research. Ewing sarcoma,
Erich J. Sohn, David S. Libich
wiley   +1 more source

Are single nucleotide polymorphisms in the IL-2 gene biomarkers for Hashimoto's thyroiditis? [PDF]

Med Pharm Rep
Chiorean AD, Bâlici Ş, Nicula GZ, Vică ML, Nechita VI, Loga LI, Bordea MA, Simon LM, Matei HV.   +8 more
europepmc   +1 more source

Stages of T cell activation: continued antigen dependence of IL 2-producing cells after IL 2 receptor expression. [PDF]

, 1986
Richard A. Miller, Marta Rozans, A. Ythier, Terry B. Strom   +3 more
openalex   +1 more source

Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy.

Nature Materials, 2012
Jason Park, S. Wrzesinski, E. Stern, M. Look, J. Criscione, R. Ragheb, Steven M. Jay, Stacey L. Demento, A. Agawu, Paula Licona Limon, A. Ferrandino, David Gonzalez, A.‐K. Habermann, R. Flavell, T. Fahmy   +14 more
semanticscholar   +1 more source

Genomic landscape and preclinical models of angiosarcoma

Molecular Oncology, Volume 19, Issue 4, Page 965-983, April 2025.
Angiosarcomas are a rare and aggressive cancer with a poor prognosis for patients. The genomic landscape of angiosarcoma can be highly complex and heterogenous; however, recent studies have identified some common features especially within anatomic and molecular subgroups.
Annaleigh Benton, Bozhi Liu, Lauren E. Gartenhaus, Jason A. Hanna   +3 more
wiley   +1 more source

Comparison of IL-2-antibody to IL-2-Fc with or without stereotactic radiation therapy in CEA immunocompetent mice with CEA positive tumors. [PDF]

Cancer Med
Williams L, Li L, Yazaki PJ, Wong P, Hong T, Poku EK, Hui S, Ghimire H, Shively JE, Kujawski M.   +9 more
europepmc   +1 more source