Results 61 to 70 of about 1,832,666 (293)

75. Evaluating the Long-term Outcomes Associated with the Use of Fresh Frozen Allograft Cartilage in Cosmetic and Reconstructive Rhinoplasty Procedures: A Prospective Controlled Clinical Trial

Plastic and Reconstructive Surgery, Global Open, 2023
Rou Wan, MD, Joshua P. Weissman, BBA, Chitang J. Joshi, MD, Genevieve Putnam, BS, Tokoya Williams, MD, Robert D. Galiano, MD, FACS   +5 more
doaj   +1 more source

Modulation of T cell responses by IL-2 and IL-2 complexes

Clinical and experimental rheumatology, 2015
Interleukin-2 (IL-2) is a cytokine centrally involved in the regulation of immune tolerance and activation by its effects on CD4+ T regulatory (Treg) cells and cytotoxic effector lymphocytes, respectively. Due to these properties IL-2 immunotherapy has been used, as low-dose IL-2, in the treatment of autoimmune and chronic-inflammatory disorders ...
Boyman Onur, Kolios Antonios G A, Raeber Miro E   +2 more
openaire   +4 more sources

Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack, A. Carolina Tufino, Mohd Azrin Jamalruddin, Sreya Dey, Yinghong Pan, Elina Mukherjee, Jessica D. Daley, Julia Meade, Mahmoud Aarabi, Lisa Maurer, James Cooper, Kara A. Bernstein, Kelly M. Bailey   +12 more
wiley   +1 more source

IL-2 based cancer immunotherapies: an evolving paradigm

Frontiers in Immunology
Discovered over 4 decades ago in the supernatants of activated T cells, interleukin-2 (IL-2) is a potent pleiotropic cytokine involved in the regulation of immune responses.
Sushama Rokade, Anita Mehta Damani, Martin Oft, Jan Emmerich   +3 more
doaj   +1 more source

INTERLEUKIN-2 – AND INTERFERON-ALPHA- INDUCED CHANGES OF PERIPHERAL BLOOD LYMPHOCYTE SUBPOPULATIONS IN CHILDREN WITH ADVANCED MALIGNANCIES, TREATED WITH CHEMOTHERAPY AND WHOLE BODY HYPERTHERMIA

Медицинская иммунология, 2014
. The effect of cytokine preparations (Interleukin-2/IL-2/Proleukin and interferon-alpha/IFN-α 2b/ Intron A) on immune cell subpopulations has been studied in the children suffering with advanced malignancies during intensive chemotherapy cycles combined
R. S. Ismail-zade, M. V. Belevtsev, M. P. Potapnev, V. P. Savitskiy, E. A. Zhavrid, S. E. Buglova   +5 more
doaj   +1 more source

Improved Outcomes for Older Children, Adolescents, and Young Adults With Neuroblastoma in the Post‐Immunotherapy Era: An Updated Report From the International Neuroblastoma Risk Group

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell, Kavitha Srivatsa, Paola Angelini, Pei‐Chi Kao, Brady Payne, Arlene Naranjo, Sveva Castelli, Miho Kato, Miki Ohira, Ulriche Pöetschger, Yaël Mossé, Lucas Moreno, Meredith S. Irwin, Ramya Ramanujachar, Wendy B. London   +14 more
wiley   +1 more source

44. A Wireless Intramuscular Near-infrared Spectroscopy Device Detects Muscle Oxygenation Changes in Porcine Model of Lower Extremity Compartment Syndrome

Plastic and Reconstructive Surgery, Global Open, 2022
Amanda Westman, PhD, Hexia Guo, MS, Yameng Xu, MS, Wubin Bai, PhD, Wei Ouyang, PhD, William Moritz, MD, Lauren Jacobson, MD, Yang Weng, MS, Hao Zang, MS, Changsheng Wu, PhD, Ziying Hu, PhD, Shuo Li, PhD, Di Lu, PhD, Hany Arafa, MS, Matthew MacEwan, MD, PhD, Lauren Tatman, MD, John Rogers, PhD, Mitchell Pet, MD   +17 more
doaj   +1 more source

ROLE OF LECTIN-SUBSTRANCE RECOGNITION IN IMMUNOREGULATORY INTERACTION BETWEEN INTERLEUKIN-2 IGG

Медицинская иммунология, 2014
As assessed by decreased response of ConA-induced blasts to IL-2, a staphylococcal protein A was shown to extract IL-2 from cultural medium after its preincubation with IgG, but it did not bind pure IL-2.
S. M. Sobolev, T. N. Nikolaeva, E. A. Grigorjeva, A. V. Pronin   +3 more
doaj   +1 more source

IL-2 regulation of soluble IL-2 receptor levels following thermal injury

Clinical and Experimental Immunology, 1992
SUMMARYIn the immunosuppresscd burn patient serum levels of both IL-2 and a soluble form of IL-2 receptor alpha (sIL-2Rα) are significantly elevated. Strikingly, the production of these markers by the in vitro activated patients' cells is decreased. This study examines the role of IL-2 in the decreased production of the sIL-2Rαin vitro in patients with
J A, Teodorczyk-Injeyan, B G, Sparkes, S, Lalani, W J, Peters, G B, Mills   +4 more
openaire   +3 more sources

Patient‐Level Barriers and Facilitators to Inpatient Physical Therapy in Adolescents and Young Adults With a Hematological Malignancy: A Qualitative Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Despite their increased risk for functional impairment resulting from cancer and its treatments, few adolescents and young adults (AYAs) with a hematological malignancy receive the recommended or therapeutic dose of exercise per week during inpatient hospitalizations.
Jennifer A. Kelleher, Jennifer L. Bernstein, Katia M. Crisler, Julia K. Herriott, Kimberly L. Klages, Robin E. Norris, Mariann L. Strenk, Sarah E. Bills, Meghan E. McGrady   +8 more
wiley   +1 more source