Results 31 to 40 of about 387,352 (250)

Brodalumab efficacy in psoriasis patients with inadequate response to IL-23 or IL-12/23 inhibitors: multicenter Italian retrospective analysis - IL PSO (Italian Landscape Psoriasis)

Dermatology Practical & Conceptual
Introduction: The use of brodalumab in patients with psoriasis who have failed other biologic drugs is an under-explored topic; A variable percentage of patients still experience primary therapeutic failure, incomplete response, or progressive loss of ...
Diego Orsini, Maria Concetta Fargnoli, Martina Burlando, Anna Campanati, Elena Campione, Claudio Guarneri, Alessandra Narcisi, Paolo Pella, Paolo Romita, Massimo Travaglini, Leonardo Zichichi, Luisa Maria Halina Arancio, Chiara Assorgi, Ginevra Baggini, Riccardo Balestri, Luca Bianchi, Alexandra Maria Giovanna Brunasso, Anna Elisabetta Cagni, Giacomo Caldarola, Gianluca Calianno, Antonio Carpentieri, Martino Carriero, Andrea Carugno, Franco Cona, Antonio Costanzo, Emanuele Cozzani, Giacomo Dal Bello, Paolo Dapavo, Annunziata Dattola, Antonio Di Tano, Federico Diotallevi, Marianna Donnarumma, Elena De Col, Maria Esposito, Carmen Silvia Fiorella, Marco Galluzzo, Francesca Graziola, Giovanni Carlo Lazzaro Danzuso, Agostina Legori, Matteo Licciardello, Viviana Lora, Piergiorgio Malagoli, Matteo Megna, Federica Mola, Gaia Moretta, Andrea Muracchioli, Attilia Musumeci, Maria Letizia Musumeci, Gianluca Pagnanelli, Vincenzo Panasiti, Eugenio Provenzano, Simone Ribero, Daniele Rizzo, Marco Rubatto, Oriele Sarno, Davide Strippoli, Fabrizio Vaira, Dario Graceffa   +57 more
doaj   +1 more source

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall, Emma N. Harrison, Genevieve C. Kendall   +2 more
wiley   +1 more source

State-of-the-Art Review on the Treatment of Axial Spondyloarthritis

Medical Sciences
The term axial spondyloarthritis (axSpA) encompasses patients with both radiographic (r-axSpA) and non-radiographic (nr-axSpA) forms of the disease. These are two entities within the same family that share many genetic and pathogenic factors, but they ...
Evripidis Kaltsonoudis, Panagiota Karagianni, Tereza Memi, Eleftherios Pelechas   +3 more
doaj   +1 more source

Association Between Dinutuximab Beta Exposure and Post‐End‐of‐Treatment Survival in Neuroblastoma: A Weighted Patient‐Level Analysis of Three Clinical Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives The association between exposure to dinutuximab beta (DB) and event‐free survival (EFS) or overall survival (OS) of neuroblastoma patients was assessed using data collected during three clinical trials (five cohorts). Methods A systematic review (March 2026) was conducted to identify relevant studies (prospective; registered DB ...
Przemysław Holko, Holger N. Lode, Alberto Garaventa, Carla Manzitti, Roberto Luksch, Dominique Valteau‐Couanet, Marion Gambart, John Anderson, Juliet Gray, Adela Canete, Lucas Moreno, Aleksandra Wieczorek, Cormac Owens, Shifra Ash, Isaac Yaniv, Genevieve Laureys, Hans Loibner, Katarzyna Śladowska, Ruth Ladenstein, Paweł Kawalec   +19 more
wiley   +1 more source

Assessment of Primary Malignancy Risk after Initiation of Biologic Therapy in Patients with Psoriasis

JID Innovations
Limited evidence exists regarding the long-term oncologic safety of biologic therapies, particularly IL-17 inhibitors and IL-23 inhibitors, in the management of psoriasis.
Chunghwan Ro, Ana Ormaza Vera, Waleed Adawi, Alexander Yap, Clinton W. Enos   +4 more
doaj   +1 more source

Global Risk of Bacterial Skin Infections and Herpesviridae Infections with Ustekinumab, Secukinumab, and Tumour Necrosis Factor-alpha Inhibitors: Spontaneous Reports of Adverse Drug Reactions from the World Health Organization Pharmacovigilance Center

Acta Dermato-Venereologica, 2022
Genetic defects in interleukin-12/23/17 immunity are associated with an increased risk of Staphylococcus aureus and herpesvirus skin infections. This study analysed spontaneous safety reports from the WHO Pharmacovigilance Center of bacterial skin or ...
Linda Davidson, Juul M.P.A. van den Reek, Florence van Hunsel, Elke M.G.J. de Jong, Bart Jan Kullberg   +4 more
doaj   +1 more source

Measurable Residual Disease Monitoring During Treatment for Pediatric Acute Myeloid Leukemia in First Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survival after relapse in pediatric acute myeloid leukemia (AML) remains poor, highlighting the critical importance of identifying prognostic factors to guide optimal relapse management. Methods We investigated the prognostic impact of multiparameter flow cytometry (MFC) measurable residual disease (MRD) in 188 patients with first ...
Camilla Poulsen, Kristian Juul Sandahl, Lene Karlsson, Jonas Abrahamsson, Nira Arad‐Cohen, Daniel Cheuk, Barbara De Moerloose, Linda Fogelstrand, Jose Maria Fernandez Navarro, Bianca F. Goemans, Kirsi Jahnukainen, Gertjan Kaspers, Zhanna Kovalova, Monica Cheng Munthe‐Kaas, Ulrika Norén‐Nyström, Josefine Palle, Ramune Pasauliene, Cornelis Jan Pronk, Kadri Saks, Anne Tierens, Henrik Hasle, Kristian Løvvik Juul‐Dam   +21 more
wiley   +1 more source

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

Bridging the Gap in Neuroblastoma Care: Consensus‐Based Statements With Recommendations for Improved Patient and Caregiver Experiences

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Neuroblastoma's complex, heterogeneous biology poses significant diagnostic and therapeutic challenges, often requiring caregivers to absorb complex information and participate in time‐sensitive decisions. However, caregivers often feel unprepared to evaluate options.
Vickie Buenger, Joseph Bauer, Jennifer Diamond, Maggie Fader, Shae Hansen, Jacqueline M. Kraveka, Johanna Schoen, Amber Shearer, Dena Sherwood   +8 more
wiley   +1 more source

IL-17 and -23 Inhibitors for the Treatment of Psoriasis

European Medical Journal Allergy & Immunology, 2023
Psoriasis is a chronic inflammatory skin condition with a significant global burden of disease and a wide array of potential treatment options, ranging from topical to systemic therapies. There are currently 11 biologic agents approved by the U.S.
Sonali Batta, Ramlah Khan, Marcus Zaayman, Allison Limmer, Dario Kivelevitch, Alan Menter   +5 more
doaj   +1 more source