Results 1 to 10 of about 5,569,467 (288)
Role of the IL-23/IL-17 Pathway in Rheumatic Diseases: An Overview
Frontiers in Immunology, 2021 Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, IL-23A (p19) and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12).
Claudia Schinocca +6 more
doaj +2 more sources
The role of IL‐23 and the use of IL‐23 inhibitors in psoriatic arthritis [PDF]
Musculoskeletal Care, 2022 Background Psoriatic arthritis (PsA) is a chronic inflammatory arthritis characterised by musculoskeletal and extra‐articular manifestations, most notably psoriasis.
G. Fragoulis, S. Siebert
semanticscholar +4 more sources
The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside
Frontiers in Immunology, 2020 Interleukin-17 (IL-17) is an essential proinflammatory cytokine, which is mainly secreted by the CD4+ helper T cells (Th17 cells) and subsets of innate lymphoid cells.
Taoming Liu +7 more
doaj +2 more sources
IL-23 past, present, and future: a roadmap to advancing IL-23 science and therapy
Frontiers in ImmunologyInterleukin (IL)-23, an IL-12 cytokine family member, is a hierarchically dominant regulatory cytokine in a cluster of immune-mediated inflammatory diseases (IMIDs), including psoriasis, psoriatic arthritis, and inflammatory bowel disease.
J. G. Krueger +14 more
semanticscholar +7 more sources
No Significant Effects of IL-23 on Initiating and Perpetuating the Axial Spondyloarthritis: The Reasons for the Failure of IL-23 Inhibitors [PDF]
Frontiers in Immunology, 2022 Axial spondyloarthritis (axSpA) is comprised of ankylosing spondylitis (AS) and non-radiographic axSpA. In recent years, the involvement of the interleukin (IL)-23/IL-17 axis in the pathophysiology of axSpA has been widely proposed.
Hua Zhang, Han-Lei Jiang, Sheng-Ming Dai
doaj +3 more sources
The regulatory mechanism and potential application of IL-23 in autoimmune diseases
Frontiers in Pharmacology, 2022 IL-23 is a heterodimeric pro-inflammatory cytokine secreted by dendritic cells and macrophages that belongs to the IL-12 family. It has pro-inflammatory effects and is a key cytokine and upstream regulatory cytokine involved in protective immune ...
De-Kai Xiong +7 more
doaj +1 more source
Frontiers in Immunology, 2021 The IL-23/IL-17 axis plays causative roles in the development and progression of systemic lupus erythematosus (SLE). However, it remains unclear if the IL-17RA+ and IL-23R+ T helper (Th) cells populations are associated with the serum IL-17 and IL-23 ...
Aziz Farah Izati +9 more
doaj +1 more source
Frontiers in Immunology, 2022 Psoriasis, a common inflammatory skin disease, is critically dependent on the IL-23/IL-17 cytokine axis. Although immune cell-derived IL-23 is generally associated with the disease pathogenesis, there have been reports of IL-23 production in ...
Young Joon Park +3 more
doaj +1 more source
IL-12 and IL-23 pathway inhibition in inflammatory bowel disease
Nature reviews: Gastroenterology & hepatology, 2023 IL-12 and IL-23 have been implicated in inflammatory bowel disease. In this Review, Vande Casteele and colleagues summarize the mechanistic role of IL-12 and IL-23 in inflammatory bowel disease, and discuss the clinical development of drugs targeting IL ...
B. Verstockt +22 more
semanticscholar +1 more source
Frontiers in Immunology, 2023 Interleukin-17 family (IL-17s) comprises six structurally related members (IL-17A to IL-17F); sequence homology is highest between IL-17A and IL-17F, displaying certain overlapping functions.
Victoria Navarro-Compán +17 more
semanticscholar +1 more source