Results 1 to 10 of about 1,425,818 (197)

The regulatory mechanism and potential application of IL-23 in autoimmune diseases

Frontiers in Pharmacology, 2022
IL-23 is a heterodimeric pro-inflammatory cytokine secreted by dendritic cells and macrophages that belongs to the IL-12 family. It has pro-inflammatory effects and is a key cytokine and upstream regulatory cytokine involved in protective immune ...
De-Kai Xiong, Xiang Shi, Miao-Miao Han, Xing-Min Zhang, Na-Na Wu, Xiu-Yue Sheng, Ji-Nian Wang, Ji-Nian Wang   +7 more
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Role of the IL-23/IL-17 Pathway in Rheumatic Diseases: An Overview

Frontiers in Immunology, 2021
Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, IL-23A (p19) and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12).
Claudia Schinocca, Chiara Rizzo, Serena Fasano, Giulia Grasso, Lidia La Barbera, Francesco Ciccia, Giuliana Guggino   +6 more
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Increased IL-23R+ Th Cells Population Exhibits Higher SLEDAI-2K Scores in Systemic Lupus Erythematosus Patients

Frontiers in Immunology, 2021
The IL-23/IL-17 axis plays causative roles in the development and progression of systemic lupus erythematosus (SLE). However, it remains unclear if the IL-17RA+ and IL-23R+ T helper (Th) cells populations are associated with the serum IL-17 and IL-23 ...
Aziz Farah Izati, Aziz Farah Izati, Nur Diyana Mohd Shukri, Nur Diyana Mohd Shukri, Wan Syamimee Wan Ghazali, Wan Syamimee Wan Ghazali, Che Maraina Che Hussin, Che Maraina Che Hussin, Kah Keng Wong, Kah Keng Wong   +9 more
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Comparative Analysis of Single-Cell Transcriptome Data Reveals a Novel Role of Keratinocyte-Derived IL-23 in Psoriasis

Frontiers in Immunology, 2022
Psoriasis, a common inflammatory skin disease, is critically dependent on the IL-23/IL-17 cytokine axis. Although immune cell-derived IL-23 is generally associated with the disease pathogenesis, there have been reports of IL-23 production in ...
Young Joon Park, Yul Hee Kim, Eun-So Lee, You Chan Kim   +3 more
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No Significant Effects of IL-23 on Initiating and Perpetuating the Axial Spondyloarthritis: The Reasons for the Failure of IL-23 Inhibitors

Frontiers in Immunology, 2022
Axial spondyloarthritis (axSpA) is comprised of ankylosing spondylitis (AS) and non-radiographic axSpA. In recent years, the involvement of the interleukin (IL)-23/IL-17 axis in the pathophysiology of axSpA has been widely proposed.
Hua Zhang, Han-Lei Jiang, Sheng-Ming Dai
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The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside

Frontiers in Immunology, 2020
Interleukin-17 (IL-17) is an essential proinflammatory cytokine, which is mainly secreted by the CD4+ helper T cells (Th17 cells) and subsets of innate lymphoid cells.
Taoming Liu, Sheng Li, Shuni Ying, Shunli Tang, Yuwei Ding, Yali Li, Jianjun Qiao, Hong Fang   +7 more
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ASPECTS OF BIODETERIORATION OF LAPIDEOUS SUBMERGED ARTEFACTS: 3D METHODOLOGIES APPLICATION [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2015
Submerged stone archaeological artefacts are bioeroded by endolithic microbiota (cyanobacteria, algae and fungi) and macroborers (Porifera, Bivalvia and Sipuncula).
S. Ricci, F. Antonelli, C. Sacco Perasso
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Circulating Interleukin-23 Levels in Rheumatoid Arthritis and its Relationship to Disease Activity: a Systematic Review with Meta-Analysis

مجله كليه طب الكندي, 2023
Background: Rheumatoid arthritis (RA) is a chronic and systemic autoimmune disease that is characterized by severe synovial inflammation, cartilage erosion, bone loss, and generalized vasculopathy.
Ahmed Azzam, Shaza Abdul Basset Abdul Basset, Heba Khaled, Neveen Refaey, Ahmed Atta Ahmed Ali, Saad abdelrahim saad shoulah, Mohammed Saleh Al Saifi, Mahmoud s.Meleha   +7 more
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Long-Term Efficacy and Safety of Guselkumab for Moderate to Severe Psoriasis: A 3-Year Real-Life Retrospective Study

Psoriasis: Targets and Therapy, 2022
Matteo Megna, Luca Potestio, Gabriella Fabbrocini, Angelo Ruggiero Section of Dermatology - Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, 80131, ItalyCorrespondence: Angelo Ruggiero, Section of Dermatology ...
Megna M, Potestio L, Fabbrocini G, Ruggiero A   +3 more
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Serum Interleukin 23 and Nitric Oxide in Vitiligo: New insights into the emerging association with VASI Score [PDF]

Zagazig University Medical Journal, 2023
Background: Vitiligo is a depigmentation disease of the skin caused by selective melanocyte degradation. In recent years, vitiligo has become known as an autoimmune disorder.Objectives: Our objective in this study was to determine serum levels of ...
Hagar Bessar, Basma Ahmed, Samar Sharaf, Afaf Ghanem   +3 more
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