Results 1 to 10 of about 1,415,590 (190)

Profile of tildrakizumab-asmn in the treatment of moderate-to-severe plaque psoriasis: evidence to date [PDF]

Psoriasis: Targets and Therapy, 2018
Kristen M Beck, Isabelle M Sanchez, Eric J Yang, Wilson Liao Department of Dermatology, University of California San Francisco, San Francisco, CA, USA Abstract: Plaque psoriasis is an immune-mediated skin disease that affects roughly 3% of adults in the ...
Beck KM, Sanchez IM, Yang EJ, Liao W
doaj   +2 more sources

Clinical benefits and complication profile of IL-23 inhibitors in patients with psoriatic arthritis: a systematic review and meta-analysis. [PDF]

Front Pharmacol
Zeng J, Lin L, Li W, Gao X, Li Q, Zhou X, Liu W, Zhong X, Yang Y, Zhang X, Luo Q.   +10 more
europepmc   +3 more sources

Bullous pemphigoid induced by anti-IL-23 monoclonal antibody in a psoriatic patient: a case report. [PDF]

Front Med (Lausanne)
Xi R, Cao Y, Zhuang Q, Ma L, Tao M, Li Y.   +5 more
europepmc   +3 more sources

The regulatory mechanism and potential application of IL-23 in autoimmune diseases

Frontiers in Pharmacology, 2022
IL-23 is a heterodimeric pro-inflammatory cytokine secreted by dendritic cells and macrophages that belongs to the IL-12 family. It has pro-inflammatory effects and is a key cytokine and upstream regulatory cytokine involved in protective immune ...
De-Kai Xiong, Xiang Shi, Miao-Miao Han, Xing-Min Zhang, Na-Na Wu, Xiu-Yue Sheng, Ji-Nian Wang, Ji-Nian Wang   +7 more
doaj   +1 more source

Role of the IL-23/IL-17 Pathway in Rheumatic Diseases: An Overview

Frontiers in Immunology, 2021
Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, IL-23A (p19) and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12).
Claudia Schinocca, Chiara Rizzo, Serena Fasano, Giulia Grasso, Lidia La Barbera, Francesco Ciccia, Giuliana Guggino   +6 more
doaj   +1 more source

Increased IL-23R+ Th Cells Population Exhibits Higher SLEDAI-2K Scores in Systemic Lupus Erythematosus Patients

Frontiers in Immunology, 2021
The IL-23/IL-17 axis plays causative roles in the development and progression of systemic lupus erythematosus (SLE). However, it remains unclear if the IL-17RA+ and IL-23R+ T helper (Th) cells populations are associated with the serum IL-17 and IL-23 ...
Aziz Farah Izati, Aziz Farah Izati, Nur Diyana Mohd Shukri, Nur Diyana Mohd Shukri, Wan Syamimee Wan Ghazali, Wan Syamimee Wan Ghazali, Che Maraina Che Hussin, Che Maraina Che Hussin, Kah Keng Wong, Kah Keng Wong   +9 more
doaj   +1 more source

Comparative Analysis of Single-Cell Transcriptome Data Reveals a Novel Role of Keratinocyte-Derived IL-23 in Psoriasis

Frontiers in Immunology, 2022
Psoriasis, a common inflammatory skin disease, is critically dependent on the IL-23/IL-17 cytokine axis. Although immune cell-derived IL-23 is generally associated with the disease pathogenesis, there have been reports of IL-23 production in ...
Young Joon Park, Yul Hee Kim, Eun-So Lee, You Chan Kim   +3 more
doaj   +1 more source

No Significant Effects of IL-23 on Initiating and Perpetuating the Axial Spondyloarthritis: The Reasons for the Failure of IL-23 Inhibitors

Frontiers in Immunology, 2022
Axial spondyloarthritis (axSpA) is comprised of ankylosing spondylitis (AS) and non-radiographic axSpA. In recent years, the involvement of the interleukin (IL)-23/IL-17 axis in the pathophysiology of axSpA has been widely proposed.
Hua Zhang, Han-Lei Jiang, Sheng-Ming Dai
doaj   +1 more source

The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside

Frontiers in Immunology, 2020
Interleukin-17 (IL-17) is an essential proinflammatory cytokine, which is mainly secreted by the CD4+ helper T cells (Th17 cells) and subsets of innate lymphoid cells.
Taoming Liu, Sheng Li, Shuni Ying, Shunli Tang, Yuwei Ding, Yali Li, Jianjun Qiao, Hong Fang   +7 more
doaj   +1 more source

IL-23 Dependent and Independent Stages of Experimental Arthritis: No Clinical Effect of Therapeutic IL-23p19 Inhibition in Collagen-induced Arthritis [PDF]

, 2013
IL-23p19 deficient mice have revealed a critical role of IL-23 in the development of experimental autoimmune diseases, such as collagen-induced arthritis (CIA).
Asmawidjaja, P. (Patrick), Cornelissen, F.H.J. (Ferry), Corneth, O.B.J. (Odilia), Kikly, K. (Kristine), Lubberts, E.W. (Erik), Mus, A.M.C. (Adriana)   +5 more
core   +11 more sources