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Role of the IL-23/IL-17 Pathway in Rheumatic Diseases: An Overview

open access: yesFrontiers in Immunology, 2021
Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, IL-23A (p19) and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12).
Claudia Schinocca   +6 more
doaj   +1 more source

Increased IL-23R+ Th Cells Population Exhibits Higher SLEDAI-2K Scores in Systemic Lupus Erythematosus Patients

open access: yesFrontiers in Immunology, 2021
The IL-23/IL-17 axis plays causative roles in the development and progression of systemic lupus erythematosus (SLE). However, it remains unclear if the IL-17RA+ and IL-23R+ T helper (Th) cells populations are associated with the serum IL-17 and IL-23 ...
Aziz Farah Izati   +9 more
doaj   +1 more source

Protocol for the safety of brodalumab regarding psychiatric comorbidities in patients with psoriasis

open access: yesEuropean Psychiatry, 2022
Introduction Brodalumab, an anti-IL17RA monoclonal antibody, is a treatment option for plaque psoriasis related to increased risk of suicidal ideation and behavior, including completed suicide.However, in the literature no causal relationship is ...
O. Pikou   +4 more
doaj   +1 more source

Characterization of the IL-17 and CD4+ Th17 Cells in the Clinical Course of Dengue Virus Infections

open access: yesViruses, 2020
The aims of this study were to determine the involvement of interleukin 17 (IL-17) and IL-17-producing cells in dengue pathogenesis. Blood samples from dengue virus (DENV)-infected patients were collected on different days after the onset of symptoms ...
Luis Alberto Sánchez-Vargas   +9 more
doaj   +1 more source

Role of IL-17 family cytokines in the progression of IPF from inflammation to fibrosis

open access: yesMilitary Medical Research, 2022
Idiopathic pulmonary fibrosis (IPF) is a fatal chronic interstitial lung disease with no established treatment and is characterized by progressive scarring of the lung tissue and an irreversible decline in lung function.
Yun-Juan Nie   +3 more
doaj   +1 more source

The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside

open access: yesFrontiers in Immunology, 2020
Interleukin-17 (IL-17) is an essential proinflammatory cytokine, which is mainly secreted by the CD4+ helper T cells (Th17 cells) and subsets of innate lymphoid cells.
Taoming Liu   +7 more
doaj   +1 more source

Interleukin-17 Links Inflammatory Cross-Talks Between Comorbid Psoriasis and Atherosclerosis

open access: yesFrontiers in Immunology, 2022
Psoriasis is a chronic, systemic, immune-mediated inflammatory disorder that is associated with a significantly increased risk of cardiovascular disease (CVD).
Yan Wang   +5 more
doaj   +1 more source

Advances in the study of the association between IL-17 and acne

open access: yesPifu-xingbing zhenliaoxue zazhi, 2023
Acne is a chronic inflammatory disease involving the sebaceous unit of hair follicles, with a complex pathogenesis. Currently, it is believed that the pathogenesis of acne is related to androgen levels, excessive sebum secretion, hyperkeratosis of hair ...
Yixue DUAN   +4 more
doaj   +1 more source

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