Results 1 to 10 of about 82,847,056 (224)

IL-12 family cytokines and autoimmune diseases: A potential therapeutic target?

Journal of Translational Autoimmunity
In recent years, the discovery of IL-12 family cytokines, which includes IL-12, IL-23, IL-27, IL-35, and IL-39, whose biological functions directly or indirectly affect various autoimmune diseases.
Xiaoyu Cui, Wu Liu, Hanxue Jiang, Qihan Zhao, Yuehong Hu, Xinyue Tang, Xianli Liu, Haoran Dai, Hongliang Rui, Baoli Liu   +9 more
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Hepatic localization of macrophage phenotypes during fibrogenesis and resolution of fibrosis in mice and man

Frontiers in Immunology, 2014
Macrophages have been found to both promote liver fibrosis and contribute to its resolution by acquiring different phenotypes based on signals from the micro-environment.
Leonie eBeljaars, Marlies eSchippers, Catharina eReker-Smit, Fernando eMartinez, Laura eHelming, Klaas ePoelstra, Barbro N Melgert   +6 more
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Effect of macrophages in semen on sperm quality

Reproductive Biology and Endocrinology, 2021
Background This was a cross-sectional study in China which analyzed the levels of macrophages (Mφ) in semen and evaluated the influence of Mφ levels in semen on sperm quality. Methods The subjects involves 78 males, 25- to 35-year old.
Gangxin Chen, Beihong Zheng
doaj   +1 more source

Immunomodulatory Tissue Factors in the Gallbladder Walls of Pediatric Patients with Chronic Calculous Cholecystitis

Children
Background: The rising rates of gallstones and cholecystectomy in pediatric populations underscore the increasing concern regarding chronic cholecystitis.
Kaiva Zīle Zariņa, Māra Pilmane, Aigars Pētersons   +2 more
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DYNAMICS OF IL12 CYTOKINE EXPRESSION IN HUMAN MACROPHAGES AFTER TREATMENT WITH DIOXIN

Вавиловский журнал генетики и селекции, 2015
Interleukin IL-12 is a key proinflammatory cytokine, synthesized by macrophages, but the information concerning the dioxin effect on its expression is still fragmentary. The presence of previously identified potential dioxin responsive elements (DREs) in
D. Y. Oshchepkov, E. V. Kashina, E. V. Antontseva, E. A. Oshchepkova, V. A. Mordvinov, D. P. Furman   +5 more
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IL-12, IL-15, and IL-18 pre-activated NK cells target resistant T cell acute lymphoblastic leukemia and delay leukemia development in vivo

OncoImmunology, 2017
NK cells have shown promise in therapy of hematological cancers, in particular against acute myeloid leukemia. In contrast, the more NK cell-resistant acute lymphoblastic leukemia (ALL) is difficult to treat with NK-cell-based therapies, and we ...
Margherita Boieri, Aina Ulvmoen, Amanda Sudworth, Clare Lendrem, Matthew Collin, Anne M. Dickinson, Lise Kveberg, Marit Inngjerdingen   +7 more
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IL-12及IL-12P40对NK抗肿瘤功能的免疫调节

Zhongguo shiyan zhenduanxue, 2004
目的　通过对正常人及肿瘤患者血清中IL 12以及IL 12P4 0含量的检测 ,观察其分子对NK细胞抗肿瘤细胞细胞毒效应的影响 ,探讨IL 12、IL 12P4 0分子在NK细胞抗肿瘤功能上的免疫调节作用。方法　ELISA酶联免疫法检测IL 12、IL 12P4 0分泌水平以及MTT释放法检测NK细胞毒活性。结果　①肿瘤患者外周血PBMC中CD3+、CD5 6+细胞阳性率低于对照组 （P
张继英, 马安伦, 聂红, 柏峻, 余奇文, 张冬青   +5 more
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Increased production of pro-inflammatory cytokines and enhanced T cell responses after activation of human dendritic cells with IL-1 and CD40 ligand

BMC Immunology, 2002
Background Various microbial, inflammatory and immune signals regulate the activation of dendritic cells (DC), determining their ability to interact with naïve T cells and to produce cytokines that direct T cell development. In particular, CD40L and IL-1
Galy Anne, Wesa Amy
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Enhanced gut barrier integrity sensitizes colon cancer to immune therapy

OncoImmunology, 2018
Oral IL-10 suppressed tumor growth in the APCmin/+ mouse/Bacteroides fragilis colon cancer model while a similar formulation of IL-12 exacerbated disease.
Neal Bhutiani, Qingsheng Li, Charles D. Anderson, Heather C. Gallagher, Magdia De Jesus, Rajbir Singh, Venkatkrishna R. Jala, Mostafa Fraig, Tao Gu, Nejat K. Egilmez   +9 more
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Role of Some Cytokines Among Infertile Women Undergoing Intracytoplasmic Sperm Injection

Medical Journal of Babylon
Background: Infertility is the incapacity to fulfill pregnancy after an appropriate time of sexual intercourse with no contraceptive measures taken. Ovulation disorders are one of the female factors that cause infertility, including polycystic ovarian ...
Dhuhaa Qasim Al-Faham, Abeer Thaher Naji Al Hasnawi, Ali Ibrahim Rahim Al-Dulaimi   +2 more
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