Results 1 to 10 of about 1,816,357 (289)

IL-12 family cytokines and autoimmune diseases: A potential therapeutic target? [PDF]

Journal of Translational Autoimmunity
In recent years, the discovery of IL-12 family cytokines, which includes IL-12, IL-23, IL-27, IL-35, and IL-39, whose biological functions directly or indirectly affect various autoimmune diseases.
Xiaoyu Cui, Wu Liu, Hanxue Jiang, Qihan Zhao, Yuehong Hu, Xinyue Tang, Xianli Liu, Haoran Dai, Hongliang Rui, Baoli Liu   +9 more
doaj   +2 more sources

Effects of glyphosate in common carp: Histopathological and immunohistochemical study [PDF]

Iraqi Journal of Veterinary Sciences, 2023
We aimed in the current study to determine the LC50 of glyphosate in common carp fish (Cyprinus carpio L.) within 24 hours in addition to studying the pathological lesions of sublethal concentration of glyphosate (25 and 50% of LC50) in kidney and liver ...
Safa F. Awad, Saevan S. Al-Mahmood
doaj   +1 more source

The Role of Interleukin-6, and IL-12+p40 in the Development of Ischemic Heart Disease

Kufa Journal for Nursing Sciences, 2023
Background: Because low-grade inflammation may play a role in the pathogenesis of coronary heart disease, and pro-inflammatory cytokines govern inflammatory cascades leading to atherosclerosis, and then to ischemic heart disease.
Dina A. A. Al-Roubaey, Nadia Habeeb Sarhan, Eman Hasani AL-Salami, Ibtihal Riyadh Najeeb, Hawraa Ghaleb Idreess   +4 more
doaj   +1 more source

The Role of Interleukin 12 in Iraqi Patients with Psoriasis

مجلة علوم ذي قار, 2022
Psoriasis is a chronic skin condition with immune-mediated inflammatory etiology. Many studies have indicated that Interleukin-12 (IL-12) plays an essential role in the severity of psoriasis.So to elucidate IL-12 role in regulating psoriasis promotion ...
Emad A. Abbas, Hind M Mousa
doaj   +1 more source

The Effect of Homocysteine on the Secretion of Il-1β, Il-6, Il-10, Il-12 and RANTES by Peripheral Blood Mononuclear Cells—An In Vitro Study

Molecules, 2021
The contemporary theory of the inflammatory-immunological pathomechanism of atherosclerosis includes the participation of interleukin-1β (Il), Il-6, Il-10, Il-12, RANTES, and homocysteine in this process.
Magdalena Borowska, Hanna Winiarska, Marzena Dworacka, Anna Wesołowska, Grzegorz Dworacki, Przemysław Łukasz Mikołajczak   +5 more
doaj   +1 more source

IL-12 and IL-23—Close Relatives with Structural Homologies but Distinct Immunological Functions

Cells, 2020
Cytokines of the IL-12 family show structural similarities but have distinct functions in the immune system. Prominent members of this cytokine family are the pro-inflammatory cytokines IL-12 and IL-23.
Doreen M. Floss, Jens M. Moll, Jürgen Scheller   +2 more
doaj   +1 more source

Phenotypic and Functional Heterogeneity of Low-Density and High-Density Human Lung Macrophages

Biomedicines, 2021
Background: Pulmonary macrophages are a highly heterogeneous cell population distributed in different lung compartments. Methods: We separated two subpopulations of macrophages from human lung parenchyma according to flotation over density gradients ...
Barbara Balestrieri, Francescopaolo Granata, Stefania Loffredo, Angelica Petraroli, Giulia Scalia, Paolo Morabito, Chiara Cardamone, Gilda Varricchi, Massimo Triggiani   +8 more
doaj   +1 more source

The multifaceted role of IL-12 in cancer

Advances in Cancer Biology - Metastasis, 2022
Interleukin-12 is a heterodimeric cytokine having many family members IL-23, IL-27, IL-35, and recently discovered IL-39, produced by macrophages and dendritic cells.
Um e Habiba, Mussarat Rafiq, Muhammad Babar Khawar, Bismillah Nazir, Gulfam Haider, Nadia Nazir   +5 more
doaj   +1 more source

Human microglial cells express a functional IL-12 receptor and produce IL-12 following IL-12 stimulation [PDF]

European Journal of Immunology, 2001
Microglial cells (MC) are IL-12 producers in the central nervous system. Here, we found that IL-12 receptor subunits beta1 and beta2 were both constitutively expressed, and up-regulated by IFN-gamma, in human primary MC. IL-12p70, after binding to its receptor, is internalized into vesicles that qualify as early endosomes as indicated by intracellular ...
Y, Taoufik, M G, de Goër de Herve, J, Giron-Michel, D, Durali, E, Cazes, M, Tardieu, B, Azzarone, J F, Delfraissy   +7 more
openaire   +2 more sources

Interleukin 12 receptor deficiency in a child with recurrent bronchopneumonia and very high IgE levels

Italian Journal of Pediatrics, 2012
Interleukin-12 (IL-12) is involved in cellular immune responses against intracellular pathogens by promoting the generation of T naive in T helper 1 (Th1) cells and by increasing interferon-gamma (IFN-gamma) production from T and natural killer (NK ...
Palamaro Loredana, Giardino Giuliana, Santamaria Francesca, Romano Rosa, Fusco Anna, Montella Silvia, Salerno Mariacarolina, Ursini Matilde, Pignata Claudio   +8 more
doaj   +1 more source