Results 41 to 50 of about 1,816,357 (289)

Why and When Are Evidence‐Based Interventions Adopted in Paediatric Supportive Care? A Qualitative Exploration of the Determinants of Photobiomodulation Implementation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Oral mucositis is a common and debilitating side effect of childhood cancer and stem cell transplant treatments. It affects the quality of life of children and young people (CYP) and places a strain on services. Photobiomodulation is recommended for oral mucositis prevention in international guidance but is poorly implemented in UK ...
Claudia Heggie, Kara A. Gray‐Burrows, Peter F. Day, Bob Phillips, Carl A. Thompson   +4 more
wiley   +1 more source

Plasmid IL-12 electroporation in melanoma [PDF]

Human Vaccines & Immunotherapeutics, 2012
Intratumoral gene electroporation uses electric charges to facilitate entry of plasmid DNA into cells in a reproducible and highly efficient manner, especially to accessible sites such as cutaneous and subcutaneous melanomas. Effective for locally treated disease, electroporation of plasmid DNA encoding interleukin-12 can also induce responses in ...
Cha, Edward, Daud, Adil
openaire   +4 more sources

Characterization and partial purification of Secretory IL-12 Inhibitory Factor [PDF]

, 2008
Background We have previously shown that supernatant from Candida albicans (CA) culture contains a Secretory Interleukin (IL)-12 Inhibitory Factor (CA-SIIF), which inhibits IL-12 production by human monocytes.
Mingyue Wang, Pranab K Mukherjee, Jyotsna Chandra, Ali Abdul Lattif, Thomas S McCormick, Mahmoud A Ghannoum   +5 more
core   +1 more source

Dexamethasone for Chemotherapy‐Induced Nausea and Vomiting Prevention in Pediatric Patients: International Consensus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An international Delphi panel of experts developed consensus statements to delineate the circumstances where the risks of dexamethasone as an antiemetic do and do not outweigh its benefits. Procedure Experts in supportive care of pediatric patients were invited to participate.
Negar Shavandi, Paula D. Robinson, Shana Jacobs, L. Lee Dupuis, the International Pediatric Dexamethasone Panel, Sameer Bakhshi, Tiene Bauters, Eva Brack, Simone Cesaro, Claire Fosbrook, Jason Freedman, Tamara MacDonald, Eloise Neumann, Venkatraman Radhakrishnan, Rod Rassekh, Florian Slimano, Johnathan Soggee, Joel Thompson, Marianne van de Wetering, Milena Villarroel, Jasper Wong   +20 more
wiley   +1 more source

Effect of ultra violet irradiation on the interplay between Th1 and Th2 lymphocytes

Frontiers in Pharmacology, 2015
Although UV radiation is used to treat several diseases, including rickets, psoriasis, eczema and jaundice, prolonged human exposure to UV radiation may result in acute and chronic health effects on the skin, eye and immune system.
Salma Y Abo Elnazar, Amany Abd-Elkader Ghazy, Hossam E. Ghoneim, AbdulRahman M. Taha, Amira M Abouelella   +4 more
doaj   +1 more source

Influence of acute cold stress on the secretion of IL-2, IL-4, IFNγ, IL-12 in vivo by mouse splenocytes

Медицинская иммунология, 2022
Current literature contains a large amount of data on the modifying effect of cold stress on the functions of immune cell system, in particular, on the secretion of cytokines by the cells of innate and adaptive immunity, mRNA expression.
I. L. Sharav’eva, S. V. Gein
doaj   +1 more source

Real‐World Pediatric Blinatumomab Administration: Access to Outpatient Care Delivery and Impact of a Hospital‐Dispensed Model

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Blinatumomab has been shown to be highly effective for patients with pediatric B‐ALL and has recently become standard of care therapy. Due to its past use in the clinical trial setting, there is limited information available about real‐world administration.
Katelyn Oranges, Kelly A. Duffy, Sara McDonough, Evelyn Kurpiewski, R. Jennifer Randall, Allison Barz Leahy, Haley M. Newman, Joyce P. Lee, Stephen P. Hunger, Anne F. Reilly, David T. Teachey, Susan R. Rheingold, Daniel J. Zheng   +12 more
wiley   +1 more source

A Phase I Double Blind, Placebo-Controlled, Randomized Study of the Safety and Immunogenicity of Electroporated HIV DNA with or without Interleukin 12 in Prime-Boost Combinations with an Ad35 HIV Vaccine in Healthy HIV-Seronegative African Adults. [PDF]

, 2015
Strategies to enhance the immunogenicity of DNA vaccines in humans include i) co-administration of molecular adjuvants, ii) intramuscular administration followed by in vivo electroporation (IM/EP) and/or iii) boosting with a different vaccine.
Anzala, O, Cox, JH, Dally, L, Egan, MA, Eldridge, JH, Fast, PE, Gilmour, J, Hannaman, D, Hayes, P, Ingabire, R, Karita, E, Kopycinski, J, Lehrman, J, Mpendo, J, Mutua, G, Nanvubya, A, Nyombayire, J, Rasmussen, B, Schmidt, C, Syvertsen, K   +19 more
core   +6 more sources

Development of Interleukin-12-Producing Capacity throughout Childhood [PDF]

, 2002
Increasing evidence indicates that the capacity to induce protective Th1 immune responses is impaired in early childhood, an observation that can be partially attributed to deficiencies in antigen-presenting-cell function. Synthesis of interleukin 12 (IL-
Upham, John W., Lee, Peter T., Holt, Barbara J., Heaton, Tricia, Prescott, Susan L., Sharp, Mary J., Sly, Peter D., Holt, Patrick G.   +7 more
core   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source