Results 41 to 50 of about 82,847,056 (224)

Multifaceted Nano-DEV-IL for Sustained Release of IL-12 to Avert the Immunosuppressive Tumor Microenvironment and IL-12-Associated Toxicities

, 2023
Interleukin-12 (IL-12) demonstrates potent antitumor activity by enhancing Th1/Th2 response, facilitating cytotoxic T-cell (CTL) recruitment into tumors, inhibiting tumor angiogenesis, and depleting immunosuppressive cells in the tumor microenvironment ...
Anjali Barnwal (14191305), Jayanta Bhattacharyya (1328937), Surajit Ganguly (15307418)   +2 more
core   +1 more source

Effect of ultra violet irradiation on the interplay between Th1 and Th2 lymphocytes

Frontiers in Pharmacology, 2015
Although UV radiation is used to treat several diseases, including rickets, psoriasis, eczema and jaundice, prolonged human exposure to UV radiation may result in acute and chronic health effects on the skin, eye and immune system.
Salma Y Abo Elnazar, Amany Abd-Elkader Ghazy, Hossam E. Ghoneim, AbdulRahman M. Taha, Amira M Abouelella   +4 more
doaj   +1 more source

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

IL-12 and Viral Infections

Cytokine & Growth Factor Reviews, 1998
Interleukin-12 activates natural killer cells and promotes the differentiation of Th1 CD4+ cells; it is a critical factor in viral immunity. IL-12 is secreted by antigen presenting cells including dendritic cells, macrophages and astrocytes, both in tissues and in secondary lymphoid organs.
Komastu, Takashi, Ireland, Derek D.C, Reiss, Carol Shoshkes   +2 more
openaire   +2 more sources

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Analysis of IL12B gene variants in inflammatory bowel disease [PDF]

, 2012
IL12B encodes the p40 subunit of IL-12, which is also part of IL-23. Recent genome-wide association studies identified IL12B and IL23R as susceptibility genes for inflammatory bowel disease (IBD).
Darina Czamara, Seiderer, J., Seiderer Julia, Ochsenkühn, Thomas, Fries, C., Julia Seiderer (107820), Beigel, F., Wagner, Johanna, Glas, J., Cornelia Tillack (174718), Friedrich, Matthias, Christian Steib (174731), Czamara, D., Diegelmann Julia, Jürgen Glas (107816), Fries Christoph, Tillack, Cornelia, Friedrich Matthias, Steib Christian, Stallhofer, Johannes, Torsten Olszak (107835), Brand, Stephan, Göke, B., Florian Beigel (174724), Brand Stephan, Thomas Ochsenkühn, Olszak Torsten, Beigel, Florian, Matthias Friedrich (174721), Thomas Ochsenkühn (174734), Stallhofer, J., Ochsenkühn, T., Johannes Stallhofer, Matthias Friedrich, Wetzke, M., Darina Czamara (107824), Stephan Brand (107861), Cornelia Tillack, Julia Diegelmann, Beigel Florian, Steib, Christian, Göke, Burkhard, Wetzke Martin, Fries, Christoph, Wagner, J., Friedrich, M., Seiderer, Julia, Glas, Jürgen, Diegelmann, J., Burkhard Göke (109829), Christoph Fries, Ochsenkühn Thomas, Wagner Johanna, Martin Wetzke, Burkhard Göke, Göke Burkhard, Christian Steib, Stephan Brand, Brand, S., Steib, C., Czamara, Darina, Martin Wetzke (107833), Stallhofer Johannes, Julia Diegelmann (107830), Jürgen Glas, Johanna Wagner (174709), Tillack Cornelia, Johanna Wagner, Wetzke, Martin, Czamara Darina, Diegelmann, Julia, Christoph Fries (174714), Johannes Stallhofer (174728), Glas Jürgen, Torsten Olszak, Olszak, T., Florian Beigel, Julia Seiderer, Olszak, Torsten, Tillack, C.   +79 more
core   +2 more sources

Memory-Like NK Cells: Remembering a Previous Activation by Cytokines and NK Cell Receptors

Frontiers in Immunology, 2018
Natural Killer (NK) cells are cytotoxic innate lymphoid cells serving at the front line against infection and cancer. In inflammatory microenvironments, multiple soluble and contact-dependent signals modulate NK cell responsiveness.
Jens H. W. Pahl, Adelheid Cerwenka, Jing Ni, Jing Ni   +3 more
doaj   +1 more source

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans [PDF]

, 2011
IL-23 and Th17 cells are key players in tissue immunosurveillance and are implicated in human immune-mediated diseases. Genome-wide association studies have shown that the IL23R R381Q gene variant protects against psoriasis, Crohn's disease and ...
Di Meglio, P, Chung-Ching Chu, Francesca Capon, Di Meglio, Paola, Napolitano, Luca, Napolitano, L, Ketty Peris, Di Cesare, Antonella, Villanova, Federica, Villanova, F, Richard C. Trembath, Isabella Tosi, Paola Di Meglio, Richard C Trembath, Laggner, Ute, Chu, Chung-Ching, Chu, CC, Capon, Francesca, Federica Villanova, Frank O Nestle, Nestle, FO, Peris, K, Nestle, Frank O., Antonella Di Cesare, Peris, Ketty, Trembath, RC, Laggner, U, Tosi, Isabella, Luca Napolitano, Capon, F, Frank O. Nestle, Ute Laggner, Trembath, Richard C., Di Cesare, A, Tosi, I, Chu Chung-Ching, Peris Ketty, Laggner Ute, Napolitano Luca, Di Meglio Paola, Nestle Frank O., Trembath Richard C., Capon Francesca, Di Cesare Antonella, Villanova Federica, Tosi Isabella   +45 more
core   +2 more sources