Revisiting the role of IL-27 in obesity-related metabolic diseases: safeguard or perturbation? [PDF]
Frontiers in ImmunologyThe prevalence of metabolic diseases, such as obesity, has been steadily increasing in recent years, posing a significant threat to public health. Therefore, early identification and intervention play a crucial role.
Jinyang An +8 more
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IL-27 as a novel biomarker for pruritus in nodular prurigo and bullous pemphigoid [PDF]
Frontiers in ImmunologyIntroductionBullous pemphigoid (BP) and prurigo nodularis (PN) are chronic pruritic skin diseases that severely impact patients’ quality of life. Despite the widespread attention these two diseases have garnered within the dermatological field, the ...
Yifei Wang +3 more
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High-intensity intermittent training promotes adipose tissue browning via the IL-27/p38 MAPK–PGC-1α signaling pathway in diet-induced obese rats [PDF]
Frontiers in PhysiologyObjectivesThis study investigated the effects of high-intensity intermittent training (HIIT) versus moderate-intensity aerobic training (MAIT) on IL-27 signalling and adipose tissue browning in obese rats.MethodsForty male Sprague–Dawley rats were ...
Chunlong Wang +3 more
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IL-27 expression regulation and its effects on adaptive immunity against viruses [PDF]
Frontiers in ImmunologyIL-27, a member of the IL-6/IL-12 cytokine superfamily, is primarily secreted by antigen presenting cells, specifically by dendric cells, macrophages and B cells.
Fernando Andres-Martin +2 more
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Expression and significance of IL-27 and IL-35 in orbital fat in patients with severe TAO [PDF]
Diagnostic PathologyTo detect the expression of Interleukin-27 (IL-27) and Interleukin-35 (IL-35) in orbital fat in patients with severe TAO (thyroid-related eye disease) exophthalmos, and to investigate its potential role and significance in the development of TAO. A study
Bing Wang +4 more
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The expression and clinical significance of IL-27 and Foxp3 in oral squamous cell carcinoma [PDF]
BMC CancerObjective This study aimed to investigate the expression and clinical significance of interleukin-27 (IL-27) and forkhead box P3 (Foxp3) in oral squamous cell carcinoma (OSCC) tissues, analyze their co-expression correlations, and explore their potential
Mengna Wu, Jiajun Fang, Tonghan Zhang
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An updated advancement of bifunctional IL-27 in inflammatory autoimmune diseases [PDF]
Frontiers in ImmunologyInterleukin-27 (IL-27) is a member of the IL-12 family. The gene encoding IL-27 is located at chromosome 16p11. IL-27 is considered as a heterodimeric cytokine, which consists of Epstein–Barr virus (EBV)-induced gene 3 (Ebi3) and IL-27p28.
Wang-Dong Xu +5 more
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Macrophage P2Y6R activation aggravates psoriatic inflammation through IL-27-mediated Th1 responses [PDF]
Acta Pharmaceutica Sinica BPurinergic signaling plays a causal role in the modulation of immune inflammatory response in the course of psoriasis, but its regulatory mechanism remains unclear.
Li Yin +12 more
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Interleukin-27 Suppresses T Helper-17 Inflammation in Allergic Rhinitis [PDF]
Iranian Journal of Immunology, 2020 Background: T helper 17 (Th17) cells and the related cytokines, interleukin (IL)- 17 and IL-23, were proved to play pivotal roles during the development of allergic rhinitis (AR).
Hong Ouyang +4 more
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The Role of gp130 Cytokines in Tuberculosis
Cells, 2020 Protective immune responses to Mycobacterium tuberculosis (Mtb) infection substantially depend on a delicate balance within cytokine networks. Thus, immunosuppressive therapy by cytokine blockers, as successfully used in the management of various chronic
Kristina Ritter +2 more
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