Results 11 to 20 of about 1,340,473 (190)

CD11a regulates hematopoietic stem and progenitor cells

open access: yesFrontiers in Immunology, 2023
Integrin αLβ2 (CD11a/CD18, CD11a) is a critical leukocyte adhesion molecule in leukocyte arrest and immunological synapse formation. However, its role in the bone marrow has not been investigated in depth.
Lifei Hou   +7 more
doaj   +1 more source

IL-27 induces LL-37/CRAMP expression from intestinal epithelial cells: implications for immunotherapy of Clostridioides difficile infection

open access: yesGut Microbes, 2021
Clostridioides difficile infection is currently the leading cause of nosocomial antibiotic-associated diarrhea and pseudomembranous colitis worldwide. Cathelicidins, a major group of natural antimicrobial peptides, have antimicrobial and immunomodulatory
Banglao Xu, Xianan Wu, Yi Gong, Ju Cao
doaj   +1 more source

Expanding Diversity in Molecular Structures and Functions of the IL-6/IL-12 Heterodimeric Cytokine Family

open access: yesFrontiers in Immunology, 2016
The interleukin (IL)-6/IL-12 family cytokines have pleiotropic functions and play critical roles in multiple immune responses. This cytokine family has very unique characteristics in that they are composed of two distinct subunits forming a heterodimer ...
Hideaki Hasegawa   +5 more
doaj   +1 more source

Interleukin-12 family cytokines and sarcoidosis

open access: yesFrontiers in Pharmacology, 2014
Sarcoidosis is a systemic granulomatous disease predominantly affecting the lungs. It is believed to be caused by exposure to pathogenic antigens in genetically susceptible individuals but the causative antigen has not been identified.
Sabine eRingkowski   +3 more
doaj   +1 more source

The value of interleukin-27 for differentiating tuberculous pleural effusion from Mycoplasma pneumoniae pneumonic effusion in children

open access: yesFrontiers in Pediatrics, 2022
ObjectivesThe early diagnosis of tuberculous pleural effusion (TPE) is challenging due to the difficulty of isolating Mycobacterium tuberculosis, and pleural biomarkers are an optional choice.
Hui Xu   +7 more
doaj   +1 more source

T cell intrinsic STAT1 signaling prevents aberrant Th1 responses during acute toxoplasmosis

open access: yesFrontiers in Immunology, 2023
Infection-induced T cell responses must be properly tempered and terminated to prevent immuno-pathology. Using transgenic mice, we demonstrate that T cell intrinsic STAT1 signaling is required to curb inflammation during acute infection with Toxoplasma ...
Aaron B. Schultz   +16 more
doaj   +1 more source

IL-23 and IL-27 Levels in Macrophages Collected from Peripheral Blood of Patients with Healing Vs Non-Healing Form of Cutaneous Leishmaniasis [PDF]

open access: yesIranian Journal of Parasitology, 2012
Background: In this study the level of IL-23 and IL-27 produced by macrophages derived from peri­pheral blood mononuclear cell culture collected from patients with healing or non-healing form of cutane­ous leishmaniasis lesion were compared before and ...
S Tolouei   +7 more
doaj   +1 more source

Interleukin-27 in Tuberculosis: A Sheep in Wolf’s Clothing?

open access: yesFrontiers in Immunology, 2022
In tuberculosis (TB), protective inflammatory immune responses and the pathological sequelae of chronic inflammation significantly depend on a timely balance of cytokine expression.
Kristina Ritter   +3 more
doaj   +1 more source

Prognostic value of plasma IL-27 on biological viability of hepatic cystic echinococcosis

open access: yesInternational Journal of Infectious Diseases, 2021
Objectives: To investigate potential biomarkers for distinguishing biological viability of hepatic cystic echinococcosis. Methods: Using Luminex assay we measured plasma concentrations of cytokine and chemokine in patients with active and non-active ...
Shadike Apaer   +10 more
doaj   +1 more source

Different methods for detecting serum markers in patients with acute graft versus host disease

open access: yesDi-san junyi daxue xuebao, 2019
Objective To clarify the consistency of the results of the 2 methods for detecting serum biomarkers in patients with acute graft versus host disease (aGVHD) in order to screen out biomarkers with clinical value and to establish a biomarker screening ...
CHEN Ting   +4 more
doaj   +1 more source

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