Results 11 to 20 of about 60,933,508 (232)
Gut Microbes, 2021 Clostridioides difficile infection is currently the leading cause of nosocomial antibiotic-associated diarrhea and pseudomembranous colitis worldwide. Cathelicidins, a major group of natural antimicrobial peptides, have antimicrobial and immunomodulatory
Banglao Xu, Xianan Wu, Yi Gong, Ju Cao
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IL-27 attenuates IL-23 mediated inflammatory arthritis [PDF]
, 2023 Interleukin 27 has both pro-inflammatory and anti-inflammatory properties in autoimmunity. The anti-inflammatory effects of IL-27 are linked with inhibition of Th17 differentiation but the IL-27 effect on myeloid cells is less studied.
Iannis E. Adamopoulos +11 more
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IL-27 controls IL-10 production in S. aureus infected macrophages.
, 2022 WT bone marrow-derived macrophages (BMDMs) were pre-treated with anti-IL-27 antibody at 10ng/ml, 50ng/ml &100ng/ml for 30minutes prior to exposure to S. aureus Newman at MOI 10 for 3 h.
John M. Leech (7934528) +3 more
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IL-27 regulates IL-18 binding protein in skin resident cells [PDF]
, 2012 IL-18 is an important mediator involved in chronic inflammatory conditions such as cutaneous lupus erythematosus, psoriasis and chronic eczema. An imbalance between IL-18 and its endogenous antagonist IL-18 binding protein (BP) may account for increased ...
Wittmann, M +23 more
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Frontiers in Immunology, 2016 The interleukin (IL)-6/IL-12 family cytokines have pleiotropic functions and play critical roles in multiple immune responses. This cytokine family has very unique characteristics in that they are composed of two distinct subunits forming a heterodimer ...
Hideaki Hasegawa +5 more
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, 2022 To investigate the effect of IL-27 on Th9 differentiation and Th1/Th2 balance. C57BL/6 (B6) mice were treated with ovalbumin to establish an allergic asthma (AA) model and subjected to IL-27 overexpression (OV) and empty vector (EV).
Yu Chen (29959) +6 more
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Interleukin-12 family cytokines and sarcoidosis
Frontiers in Pharmacology, 2014 Sarcoidosis is a systemic granulomatous disease predominantly affecting the lungs. It is believed to be caused by exposure to pathogenic antigens in genetically susceptible individuals but the causative antigen has not been identified.
Sabine eRingkowski +3 more
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Frontiers in Pediatrics, 2022 ObjectivesThe early diagnosis of tuberculous pleural effusion (TPE) is challenging due to the difficulty of isolating Mycobacterium tuberculosis, and pleural biomarkers are an optional choice.
Hui Xu +7 more
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IL-27 Limits Type 2 Immunopathology Following Parainfluenza Virus Infection. [PDF]
, 2017 Respiratory paramyxoviruses are important causes of morbidity and mortality, particularly of infants and the elderly. In humans, a T helper (Th)2-biased immune response to these infections is associated with increased disease severity; however, little is
Alex Valenzuela (3699931) +38 more
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T cell intrinsic STAT1 signaling prevents aberrant Th1 responses during acute toxoplasmosis
Frontiers in Immunology, 2023 Infection-induced T cell responses must be properly tempered and terminated to prevent immuno-pathology. Using transgenic mice, we demonstrate that T cell intrinsic STAT1 signaling is required to curb inflammation during acute infection with Toxoplasma ...
Aaron B. Schultz +16 more
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