Isolation of Leishmania Promastigote Flagella [PDF]
, 2020 Eukaryotic flagella are conserved multifunctional organelles with roles in motility, intercellular interactions, and signal transduction. Leishmania possess a single flagellum at all stages of their life cycle. Flagella of promastigote forms in the fly are long and motile, with a canonical 9 + 2 microtubule axoneme and an extra-axonemal paraflagellar ...
Beneke, T +3 more
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Perillic Acid Synergizes With the Miltefosine Leishmanicidal Effect Against Leishmania amazonensis. [PDF]
Parasite ImmunolABSTRACT Perillic acid (PA), a monocyclic monoterpene derived from limonene, was evaluated for its leishmanicidal activity alone and in combination with miltefosine, as well as in its microemulsion‐based formulation. PA demonstrated synergistic activity with miltefosine and was effective against both promastigote and amastigote forms of Leishmania ...
Ferreira C +6 more
europepmc +2 more sources
The atypical dual-specificity protein phosphatase (DUSP)/kinatase of Leishmania infantum modulates infectivity, oxidative stress response and antimonial resistance. [PDF]
PLoS Neglected Tropical DiseasesDual-specificity protein phosphatases (DUSPs) are key modulators of mitogen-activated protein kinase (MAPK) signaling pathways that regulate cellular proliferation, differentiation, and stress adaptation.
Juliana Martins Ribeiro +9 more
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Opšta Medicina, 2022 Introduction. The most common form of leishmaniasis is cutaneous leishmaniasis. It presents with cutaneous lesions of the unprotected parts of the skin which leave scars later on. The causative agents are protozoae from the Leishmania species , and there
Dacić Slavica D. +2 more
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The Characterization and Antileishmanial Evaluation on Leishmania Major with Chitosan/Zno Bio-Nanocomposite as Drug Delivery Systems [PDF]
Nanomedicine Research Journal, 2022 Background: Leishmaniasis is a global disease that poses a threat to human life and is associated with complications. Current medications have limitations due to serious side effects, costs and drug resistance.
Mohsen Mahmoudi +7 more
doaj +1 more source
Determination of the Effective Dose of Curcumin alone and in Combination with Antimicrobial Peptide CM11 on Promastigote Forms of Iranian Strain of L. major (MRHO / IR / 75 / ER) [PDF]
Archives of Razi Institute, 2019 Zoonotic cutaneous leishmaniasis t caused by Leishmania major is spread in focal areas of more than 90 countries in the tropics, subtropics, and southern Europe.
G. Aqeele +4 more
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Visceral Leishmaniasis, Northern Somalia, 2013–2019
Emerging Infectious Diseases, 2020 We identified visceral leishmaniasis caused by Leishmania donovani in a previously unknown focus in northern Somalia. Clinical and epidemiologic characteristics of 118 cases during 2013–2019 in Bosaso, the region’s commercial capital, have raised ...
Mikko K. Aalto +5 more
doaj +1 more source
Antiparasitic and cytotoxicity effects of 7-hydroxy-4′- methoxy isoflavone against Leishmania major [PDF]
Journal of HerbMed Pharmacology, 2023 Introduction: Leishmaniasis caused by Leishmania spp. is observed in most parts of the world. Although, glucantime, a pentavalent antimony compound, and other synthetic drugs are broadly applied for leishmaniasis therapy; however, the use of these ...
Mahdi Aghaei +5 more
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Journal of Zoonotic Diseases, 2023 The disease Leishmaniasis is a neglected illness with two major forms clinically including cutaneous leishmaniasis and visceral leishmaniasis. From almost 100 endemic countries, an estimated one million additional records of leishmaniasis each year are
Basim Saleem Ahmed Al Sulivany +1 more
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Pathogens, 2022 Leishmaniasis is a protozoal vector-borne disease that affects both humans and animals. In the Mediterranean Basin, the primary reservoir hosts of Leishmania spp. are mainly rodents and canids.
Cyrine Bouabid +11 more
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