Results 41 to 50 of about 11,689 (228)

Coumarin‐Benzimidazole Hybrids as Multitarget Scaffolds for Antileishmanial Drug Discovery

ChemistrySelect, Volume 11, Issue 38, 13 October 2026.
Coumarin‐benzimidazole hybrids emerge as promising antileishmanial agents through virtual screening against essential Leishmania enzymes, Cathepsin B (CatB), and N‐myristoyltransferase (NMT). Molecular docking and dynamics simulations reveal highly stable target interactions that surpass the reference drug miltefosine (MTF).
Fernanda Melo Jucá, Damião Sampaio de Sousa, Caio Henrique Alexandre Roberto, Márcia Machado Marinho, Emmanuel Silva Marinho   +4 more
wiley   +1 more source

Metalloprotease Gp63-Targeting Novel Glycoside Exhibits Potential Antileishmanial Activity

Frontiers in Cellular and Infection Microbiology, 2022
Visceral leishmaniasis (VL) and post kala-azar dermal leishmaniasis (PKDL) affect most of the poor populations worldwide. The current treatment modalities include liposomal formulation or deoxycholate salt of amphotericin B, which has been associated ...
Amrita Chakrabarti, Chintam Narayana, Nishant Joshi, Swati Garg, Swati Garg, Lalit C. Garg, Anand Ranganathan, Ram Sagar, Ram Sagar, Soumya Pati, Shailja Singh, Shailja Singh   +11 more
doaj   +1 more source

Synthesis, Anti‐Leishmania amazonensis Activity, Cytotoxicity, and Molecular Docking of Anthranilate–Naphthoquinone Hybrids

ChemistrySelect, Volume 11, Issue 40, 27 October 2026.
New anthranilate–naphthoquinone hybrids display potent inhibition of Leishmania (L.) amazonensis with low host cell toxicity. Molecular docking reveals key interactions with TR, GP63, and PTR1, suggesting a multitarget mechanism that contributes to parasite death.
Eduardo Miranda da Silva Magesfeste, Lidilhone Hamerski, Diego Mendes Nunes, Ana Paula Sotero da Silva Ribeiro, Elvira Maria Saraiva, Magaly Girão Albuquerque, Camilo Henrique da Silva Lima, Bárbara Vasconcellos da Silva   +7 more
wiley   +1 more source

Kinetoplastid membrane protein-11 is present in promastigotes and amastigotes of Leishmania amazonensis and its surface expression increases during metacyclogenesis

Memorias do Instituto Oswaldo Cruz, 2010
Kinetoplastid membrane protein-11 (KMP-11), a protein present in all kinetoplastid protozoa, is considered a potential candidate for a leishmaniasis vaccine.
Denise CS Matos, Lanuza AP Faccioli, Léa Cysne-Finkelstein, Paula Mello De Luca, Suzana Corte-Real, Geraldo RG Armôa, Elezer Monte Blanco Lemes, Débora Decote-Ricardo, Sergio CF Mendonça   +8 more
doaj   +1 more source

Effect of Different Types of Blood on the Growth of Cutaneus Leishmaniasis Agent in Vitro

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2007
Introduction: As there is a high prevalence of cutaneous Leishmaniasis in Iran, the problems and expenses for culture of the parasite are important. The effect of different types of blood human, cattle, sheep and goat on growth of leishmania tropica ...
M Saffari, Z Vakili, S Taheri
doaj  

Peptide‐Enabled Nanoplatforms for Malaria and Leishmaniasis: From Intracellular Targeting to Translational Diagnostic Perspectives

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
Peptide‐enabled nanoplatforms offer multifunctional strategies for the treatment and diagnosis of malaria and leishmaniasis. Liposomal, polymeric, and metallic nanocarriers, together with cell‐penetrating peptides and parasite‐derived mimotopes, can improve targeted drug delivery, stability, bioavailability, and intracellular localization.
Christian S. Carnero Canales, Ana Clara Lunardi Yagi, Túlio Custódio Reis, Jessica Ingrid Cazorla, Jade Rojas Villar, Marcia A. Graminha, Roxana Yesenia Pastrana Alta, Fernando Rogério Pavan   +7 more
wiley   +1 more source

Response of Leishmania chagasi promastigotes to oxidant stress [PDF]

Infection and Immunity, 1994
At the onset of infection, Leishmania promastigotes are phagocytized by mammalian macrophages. They must survive despite exposure to toxic oxidants such as hydrogen peroxide (H2O2) and superoxide (.O2-) generated during phagocytosis. We investigated the effects of these oxidants on Leishmania chagasi promastigotes and promastigote mechanisms for ...
M E, Wilson, K A, Andersen, B E, Britigan   +2 more
openaire   +2 more sources

Transmission of cutaneous leishmaniasis by sand flies is enhanced by regurgitation of fPPG [PDF]

, 2004
Sand flies are the exclusive vectors of the protozoan parasite Leishmania, but the mechanism of transmission by fly bite has not been determined nor incorporated into experimental models of infection.
Bates, Paul A., Ilg, T., Nikolaev, Andrei V., Ferguson, Michael AJ, Andrei V. Nikolaev, Matthew E. Rogers, Ilg, Thomas, Ferguson, Michael A. J.; id_orcid, Ferguson, M. A. J., Rogers, Matthew E., Ferguson, Michael A J, Paul A. Bates, Michael A. J. Ferguson, Rogers, Matthew E, Thomas Ilg, Bates, Paul, Nikolaev, Andrei V, Bates, Paul A, Nikolaev, A. V.   +18 more
core   +1 more source

Data of analysis by one way ANOVA test for promastigote mortality, arginase activity, gene expression, NO generation, ROS production, cell cycle and program cell death.

, 2023
Data of analysis by one way ANOVA test for promastigote mortality, arginase activity, gene expression, NO generation, ROS production, cell cycle and program cell death.
Razieh Tavakoli Oliaee (12481732), Fatemeh Sharifi (3496619), Iraj Sharifi, Razieh Tavakoli Oliaee, Ahmad Khosravi (525161), Ahmad Khosravi, Alireza Keyhani (4960432), Mehdi Bamorovat (4836909), Fatemeh Sharifi, Ehsan Salarkia (6831890), Zahra Babaei (806332), Zahra Babaei, Mehdi Bamorovat, Ehsan Salarkia, Alireza Keyhani, Iraj Sharifi (344800)   +15 more
core   +1 more source

IAA Synthesis Pathway of Fitibacillus barbaricus WL35 and Its Regulatory Gene Expression Levels in Potato (Solanum tuberosum L.)

Microorganisms
Indole-3-acetic acid (IAA), as an important regulator of potato growth, seriously affects the growth and yield of potato. Although many studies have reported that IAA-producing Bacillus can promote plant growth, little research has been conducted on its ...
Xiaoyu Li, Huan Tao, Shisong Wang, Di Zhang, Xingyao Xiong, Yanfei Cai   +5 more
doaj   +1 more source