Results 41 to 50 of about 11,452 (171)

Secondary structure of the promastigote surface protease of Leishmania [PDF]

, 1988
By Raman spectroscopic analysis we have determined the secondary structure of the promastigote surface protease, named PSP or gp63, of Leishmania major. It consist of nearly 50% antiparallel β-strand, and less than 20% α-helix.
Etges, Robert, Jähnig, Fritz, Fritz Jähnig, Robert Etges   +3 more
core   +1 more source

Metalloprotease Gp63-Targeting Novel Glycoside Exhibits Potential Antileishmanial Activity

Frontiers in Cellular and Infection Microbiology, 2022
Visceral leishmaniasis (VL) and post kala-azar dermal leishmaniasis (PKDL) affect most of the poor populations worldwide. The current treatment modalities include liposomal formulation or deoxycholate salt of amphotericin B, which has been associated ...
Amrita Chakrabarti, Chintam Narayana, Nishant Joshi, Swati Garg, Swati Garg, Lalit C. Garg, Anand Ranganathan, Ram Sagar, Ram Sagar, Soumya Pati, Shailja Singh, Shailja Singh   +11 more
doaj   +1 more source

Therapeutic Effects of Matricaria chamomilla Extract in an Immunosuppressed Mouse Model of Cryptosporidiosis

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
Chamomile (Matricaria chamomilla) extract significantly reduced oocyst shedding and intestinal lesions in immunosuppressed mice infected with Cryptosporidium parvum, while enhancing antioxidant defences (GPx, TAC). These findings suggest chamomile as a promising phytotherapeutic agent for cryptosporidiosis. ABSTRACT Background Cryptosporidiosis, caused
Kousha Kiani, Mohammad Hashemnia, Farid Rezaei, Hadi Cheraghi   +3 more
wiley   +1 more source

Kinetoplastid membrane protein-11 is present in promastigotes and amastigotes of Leishmania amazonensis and its surface expression increases during metacyclogenesis

Memorias do Instituto Oswaldo Cruz, 2010
Kinetoplastid membrane protein-11 (KMP-11), a protein present in all kinetoplastid protozoa, is considered a potential candidate for a leishmaniasis vaccine.
Denise CS Matos, Lanuza AP Faccioli, Léa Cysne-Finkelstein, Paula Mello De Luca, Suzana Corte-Real, Geraldo RG Armôa, Elezer Monte Blanco Lemes, Débora Decote-Ricardo, Sergio CF Mendonça   +8 more
doaj   +1 more source

Different Transcriptomic Responses After Moderate and Severe Heat Shock in Trypanosoma cruzi Epimastigotes

Journal of Eukaryotic Microbiology, Volume 73, Issue 5, September/October 2026.
ABSTRACT Trypanosoma cruzi undergoes heat stress during its life cycle. In this study, we performed a transcriptomic analysis of the heat shock response in epimastigotes from different T. cruzi strains. In both clone CL Brener and the Y strain, very few to no statistically significant variations were observed in the transcriptome at 37°C, whereas ...
Thayane Bottaro, Luciana L. Penha, Rosane Silva, Turán P. Ürményi   +3 more
wiley   +1 more source

Effect of Different Types of Blood on the Growth of Cutaneus Leishmaniasis Agent in Vitro

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2007
Introduction: As there is a high prevalence of cutaneous Leishmaniasis in Iran, the problems and expenses for culture of the parasite are important. The effect of different types of blood human, cattle, sheep and goat on growth of leishmania tropica ...
M Saffari, Z Vakili, S Taheri
doaj  

Pyridyl‐Thiazole‐Thiosemicarbazones as Antitrypanosomatidae Agents: Design, Synthesis, and In Silico Profiling

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
A novel pyridine–thiazole derivative, Compound 8, exhibited potent dual antitrypanosomatid activity. It demonstrated remarkable in vitro efficacy against Trypanosoma cruzi (IC50 = 1.0 µM) and L. amazonensis (IC50 = 3.9 µM). Molecular docking studies suggested interactions with heme and multiple molecular targets.
Anderson José Firmino Santos da Silva, Daiane Santiago da Cruz Olimpio, Lucas Manoel da Silva Sousa, Graziella Leite Brondani, Tacylla Lima Silva, Wéllyda Belmira de Lira Silva, Natáli Tereza Capistrano Costa, Marcelo Zaldini Hernandes, Policarpo Ademar Sales Junior, Valéria Rêgo Alves Pereira, Ana Cristina Lima Leite   +10 more
wiley   +1 more source

Effect of haemoglobin on promastigote growth.

, 2017
Promastigotes were cultured in triplicate in three media differing in haemoglobin content; M1 (0.0099 g/L), M2 (0.495 g/L) and M3 (0.99 g/L). These media were accompanied by a negative control medium containing no haemoglobin (M0).
Joel Barratt (697223), Alexa Kaufer (3637477), Douglas Craig (3637471), Bryce Peters (3637474), Damien Stark (697228), Rogan Lee (697225), Tamalee Roberts (697222), Andrea Lawrence (3637483), John Ellis (697227), Gary McAuliffe (3637480)   +9 more
core   +1 more source

IAA Synthesis Pathway of Fitibacillus barbaricus WL35 and Its Regulatory Gene Expression Levels in Potato (Solanum tuberosum L.)

Microorganisms
Indole-3-acetic acid (IAA), as an important regulator of potato growth, seriously affects the growth and yield of potato. Although many studies have reported that IAA-producing Bacillus can promote plant growth, little research has been conducted on its ...
Xiaoyu Li, Huan Tao, Shisong Wang, Di Zhang, Xingyao Xiong, Yanfei Cai   +5 more
doaj   +1 more source

Synthesis and Antiparasitic Activities of New Organometallic Derivatives of the Benzimidazole Anthelmintic Drugs

ChemBioChem, Volume 27, Issue 15, 14 August 2026.
Organometallic derivatization of existing drugs is a common strategy to look for new drug candidates. This work describes the derivatization of the benzimidazole anthelmintic scaffold, from the synthesis of the organometallic derivatives to the evaluation of their biological properties. It highlights a broad range of antiparasitic activities and leaves
Corentin Ludwig, Aya C. Taki, Joseph J. Byrne, Pierre Mesdom, Olivier Blacque, Cécile Häberli, Trix Zumkehr, Gonzalo Scalese, Leticia Pérez‐Díaz, Dinorah Gambino, Britta Lundström‐Stadelmann, Jennifer Keiser, Robin B. Gasser, Kevin Cariou, Gilles Gasser   +14 more
wiley   +1 more source