Results 51 to 60 of about 11,689 (228)

Beyond the Active Site: First‐In‐Class Leishmania Infantum Trypanothione Reductase Dimerization Disruptors as Antileishmanial Leads

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
This review outlines a pioneering strategy to inhibit Leishmania infantum trypanothione reductase by disrupting its dimer interface. From peptides to small‐molecule proteomimetics, multiple chemotypes achieved potent enzymatic inhibition and notable cellular antileishmanial activity, highlighting a new therapeutic paradigm.
María‐José Camarasa, Miguel Maldonado, Alvaro de la Cruz‐Potenciano, Sonia de Castro   +3 more
wiley   +1 more source

Oxidant-mediated damage of Leishmania donovani promastigotes [PDF]

Infection and Immunity, 1982
Dissemination of Leishmania within the host is related to parasites undergoing unchecked proliferation. We therefore studied the effects of oxidant generating systems on promastigote multiplication by (i) direct determinations of organism proliferation and (ii) the incorporation of [3H]uracil into promastigote nucleoprotein.
N E, Reiner, J W, Kazura
openaire   +2 more sources

Promastigote growth curves of strains from the non-treated (NT) and treated relapsed (TR) groups.

, 2016
No significant differences were found between promastigote counts for any of the isolates on respective days (Repeated measures ANOVA with Greenhouse-Geisser tests, P = 0.784).
Daniel Yasur-Landau (843674), Lior David (22328), Gad Baneth (254948), Charles L. Jaffe (254946)   +3 more
core   +1 more source

Chemical Characterization, Leishmanicidal Activity and In Vitro Cytotoxicity of the Essential Oil Extracted from Pectis brevipedunculata (Gardner) Sch.Bip. and Its Incorporation into Microemulsion Systems

Pharmaceutics
Pectis brevipedunculata (Gardner) Sch.Bip., known in Brazil as alecrim do campo, is a small Asteraceae family plant with a calming effect and consumed as tea.
Auxiliadora Cristina Correa Barata Lopes, Jessyane Rodrigues do Nascimento, Marcos Bispo Pinheiro Camara, Aldilene da Silva Lima, Gláucia Laís Nunes Lopes, Matheus Oliveira do Nascimento, Júlia Karla Albuquerque Melo Xavier, Caroline Martins de Jesus, Cáritas de Jesus Silva Mendonça, André Luis Menezes Carvalho, Lucilene Amorim Silva, Cláudia Quintino da Rocha   +11 more
doaj   +1 more source

Synthesis and Evaluation of Peptoid‐Based Compound Libraries as Inhibitors of Parasite Metallo‐Aminopeptidases

ChemMedChem, Volume 21, Issue 17, 14 September 2026.
Evaluation of two libraries of peptoid‐based compounds for inhibitory activity against PfA‐M1 from Plasmodium falciparum, TcLAP from Trypanosoma cruzi, and LmLAP from Leishmania major reveals the crucial role of hydrophobic interactions in the inhibition process of these parasite metallo‐aminopeptidases.
Mirta Elisa Aguado, Gerardo M. Ojeda‐Carralero, Mario Antonio Rodríguez, Isabella Rúa, Heisy Guerra, Edoardo Bailo Hernández, Guglielmo Coppola, Susana Alberti, Ariatne Rodríguez, Maikel Izquierdo, Christian Betzel, Filippo Pettazzi, Julieta Coro‐Bermello, Erik V. Van der Eycken, Bernhard Westermann, Jorge González‐Bacerio, Daniel G. Rivera   +16 more
wiley   +1 more source

Leishmania major: differential regulation of the surface metalloprotease in amastigote and promastigote stages.

, 1992
During its life cycle, the protozoan parasite Leishmania major alternates from an intracellular amastigote form in the mammalian host to a flagellated promastigote form in the insect vector.
Bouvier, J., Louis, J., Rosat, J.P., Bordier, C., Schneider, P., Rosat JP, Bouvier J, Louis J, Bordier C, Schneider P   +9 more
core   +1 more source

In Vitro Antileishmanial Effects of Saffron Compounds, Crocin and Stigmasterol, on Iranian Strain of Leishmania major (MHOM/IR/75/ER)

Iranian Journal of Parasitology, 2021
Background: Due to numerous side effects of common drugs in treatment of leishmaniasis, new therapeutic approaches focus on herbal compounds. Therefore, we aimed to determine the effect of crocin and stigmasterol on in-vitro growth of promastigotes and ...
Reza RANJBAR, Peyman SHAYANFAR, Mahmood MANIATI   +2 more
doaj  

Byrsonima crassifolia: Ethnobotany, Phytochemistry, and Pharmacology – An Update

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Current knowledge on B. crassifolia is integrated, linking its phytochemical diversity with reported pharmacological activities and highlighting the therapeutic potential of this medicinal species. ABSTRACT Byrsonima crassifolia is a fruit‐bearing species widely distributed across tropical regions of the Americas with potential health applications ...
João de Jesus Oliveira Junior, Débora Luana Ribeiro Pessoa, Marilene Oliveira da Rocha Borges   +2 more
wiley   +1 more source

Leishmania donovani development in Phlebotomus argentipes: comparison of promastigote- and amastigote-initiated infections. [PDF]

, 2016
Leishmania parasites alternate in their life cycle between promastigote stages that develop in the gut of phlebotomine sand flies and amastigotes residing inside phagocytic cells of vertebrate hosts.
Yeo, Matthew, Sadlova, Jovana, Volf, Petr, Votypka, Jan, Myskova, Jitka, Lestinova, Tereza   +5 more
core   +1 more source

Effect of Allopurinol on L. Major Promastigots Resistant to Glucantim In vitro [PDF]

Journal of Kerman University of Medical Sciences, 2003
Treatment of Leishmaniasis which is endemic in 97 conutries around the world is important and is ranked 7th among research priority of WHO. As the number of resistant types to glucantim (drug of choice) is increasing, investigation on the effect of other
M Shamsi-Meymandi, Sh Dabiri, M Bahreini
doaj