Results 51 to 60 of about 11,452 (171)

Chemical Characterization, Leishmanicidal Activity and In Vitro Cytotoxicity of the Essential Oil Extracted from Pectis brevipedunculata (Gardner) Sch.Bip. and Its Incorporation into Microemulsion Systems

Pharmaceutics
Pectis brevipedunculata (Gardner) Sch.Bip., known in Brazil as alecrim do campo, is a small Asteraceae family plant with a calming effect and consumed as tea.
Auxiliadora Cristina Correa Barata Lopes, Jessyane Rodrigues do Nascimento, Marcos Bispo Pinheiro Camara, Aldilene da Silva Lima, Gláucia Laís Nunes Lopes, Matheus Oliveira do Nascimento, Júlia Karla Albuquerque Melo Xavier, Caroline Martins de Jesus, Cáritas de Jesus Silva Mendonça, André Luis Menezes Carvalho, Lucilene Amorim Silva, Cláudia Quintino da Rocha   +11 more
doaj   +1 more source

Actinomycin Derivatives: Structural Diversification and Biological Activities

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Actinomycins are chromopeptide antibiotics exhibiting remarkable structural diversity and broad bioactivity. This review traces their development from naturally occurring D‐, X‐, A‐, G‐, Y‐, and Z‐type analogs to precursor‐directed, synthetic, and semisynthetic derivatives.
Özge Can, Erdal Bedir
wiley   +1 more source

Leishmania infantum proteophosphoglycans regurgitated by the bite of its natural sand fly vector, Lutzomyia longipalpis, promote parasite establishment in mouse skin and skin-distant tissues

, 2010
We demonstrate that a proteophosphoglycan-rich gel secreted by Leishmania infantum inside the midgut of Lutzomyia longipalpis sand flies (promastigote secretory gel) is regurgitated along with an average dose of 500 L.
Müller, Ingrid, Bates, Paul Andrew, Corware, Karina, Matthew Edward Rogers, Karina Corware, Rogers, Matthew Edward, Paul Andrew Bates, Ingrid Müller   +7 more
core   +1 more source

In Vitro Antileishmanial Effects of Saffron Compounds, Crocin and Stigmasterol, on Iranian Strain of Leishmania major (MHOM/IR/75/ER)

Iranian Journal of Parasitology, 2021
Background: Due to numerous side effects of common drugs in treatment of leishmaniasis, new therapeutic approaches focus on herbal compounds. Therefore, we aimed to determine the effect of crocin and stigmasterol on in-vitro growth of promastigotes and ...
Reza RANJBAR, Peyman SHAYANFAR, Mahmood MANIATI   +2 more
doaj  

HetCA/STOCSY‐Guided Dereplication of Artemisia arborescens Reveals Furofuran Lignans with Antileishmanial Effects

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Bioactive metabolites can remain hidden in negligible activity extracts. A statistical spectroscopy–driven dereplication workflow integrating the HeteroCovariance Approach (HetCA) and Statistical Total Correlation Spectroscopy (STOCSY) prioritized furofuran lignans in Artemisia arborescens, identifying three compounds with moderate antileishmanial ...
Olga Karoutzou, Stavros Beteinakis, Olga Koutsoni, Despina Smirlis, Maria Halabalaki, Leandros Alexios Skaltsounis, Emmanuel Mikros   +6 more
wiley   +1 more source

Effect of Allopurinol on L. Major Promastigots Resistant to Glucantim In vitro [PDF]

Journal of Kerman University of Medical Sciences, 2003
Treatment of Leishmaniasis which is endemic in 97 conutries around the world is important and is ranked 7th among research priority of WHO. As the number of resistant types to glucantim (drug of choice) is increasing, investigation on the effect of other
M Shamsi-Meymandi, Sh Dabiri, M Bahreini
doaj  

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

Advanced Healthcare Materials, Volume 15, Issue 30, 14 August 2026.
Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano, M. Carmen Mera‐Delgado, Esther Moreno, Esther Larrea, Lecnia Aguirre, Jonathan Miguel Zanatta, Sónia Barros‐Carvalho, Iola F. Duarte, Ricardo Silvestre, Juan M. Irache, Javier Carrión, Socorro Espuelas   +11 more
wiley   +1 more source

Damage to the promastigote surface membrane visualised by flow cytometry.

, 2013
PI-signal in flow cytometry, after incubation with chemokines, positive cells as a percentage of gated cells (A). Plots showing side scatter (y-axis) and forward scatter (x-axis) of untreated promastigote cells (B), and cells treated with Amphotericin B (
Matthias Mörgelin (109607), Paul Bates (134046), Mattias Collin (62685), Arne Egesten (365606), Oonagh Shannon (194608), Sara K. Söbirk (393666)   +5 more
core   +1 more source

Anti-Leishmanial Activity of Pelargonium roseum Essential Oil on Growth of Leishmania infantum Promastigotes

Medical Laboratory Journal, 2017
Background and Objectives: Due to adverse effects of pentavalent  antimonial  treatment of visceral leishmaniasis using herbal medicines has received a lot of attention.
Mohaddeseh Abouhosseini Tabari, Mohammad Reza Youssefi, Bibi Razieh Hosseini Farash, Mohammad Amin Ebrahimi, Niki Nabavi Mousavi, Elham Moghaddas   +5 more
doaj  

Characterization of Leishmania (Viannia) braziliensis membrane microdomains, and their role in macrophage infectivity

Journal of Lipid Research, 2006
Detergent-resistant membranes (DRMs) from Leishmania (Viannia) braziliensis promastigotes, insoluble in 1% Triton X-100 at 4°C, were fractionated by sucrose density gradient ultracentrifugation.
Kelly A.G. Yoneyama, Ameria K. Tanaka, Thais G.V. Silveira, Helio K. Takahashi, Anita H. Straus   +4 more
doaj   +1 more source