Cell Reports, 2016 Participation of B cells in the immune response by various antibody-independent mechanisms has recently been uncovered. B cells producing cytokines have been described for several infections and appear to regulate the adaptive immune response.
Sasha Silva-Barrios +6 more
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Sphingosine-1-phosphate receptor signaling regulates an ERK1/2–p65 molecular switch in macrophages during Leishmania donovani infection [PDF]
Frontiers in PharmacologyLeishmania donovani establishes intracellular infection by suppressing macrophage inflammatory responses. Although sphingosine-1-phosphate (S1P) signaling is known to regulate macrophage function, the receptor isotype–specific mechanisms involved during ...
Mohd Arish, Mohd Arish, Farha Naz
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In vitro antipromastigote activity of decoction and hydrodistillation extracts of Clematis hirsuta leaves against Leishmania donovani and Leishmania aethiopica [PDF]
BMC Complementary Medicine and TherapiesLeishmaniasis remains a significant health concern in four eco-epidemiological regions of the world (WHO, 2024). Annually, there are thought to be 700,000 to 1 million new cases of leishmaniasis.
Etsegenet Abebe +10 more
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CRISPR-Cas9-Mediated Genome Editing in
mBio, 2015 The prokaryotic CRISPR (clustered regularly interspaced short palindromic repeat)-Cas9, an RNA-guided endonuclease, has been shown to mediate efficient genome editing in a wide variety of organisms.
Wen-Wei Zhang, Greg Matlashewski
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Comparison of Bloodmeal Digestion and the Peritrophic Matrix in Four Sand Fly Species Differing in Susceptibility to Leishmania donovani. [PDF]
PLoS ONE, 2015 The early stage of Leishmania development in sand flies is closely connected with bloodmeal digestion. Here we compared various parameters of bloodmeal digestion in sand flies that are either susceptible (Phlebotomus argentipes and P.
Katerina Pruzinova +5 more
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Direct sequencing of Leishmania donovani from patients in Garissa County, Northern Kenya, reveals a newly emerging intra-specific hybrid genotype. [PDF]
PLoS Neglected Tropical DiseasesIntroductionLeishmaniasis is endemic in many countries, and in Kenya outbreaks of visceral leishmaniasis (VL) commonly occur in Garissa, Isiolo, Marsabit, Turkana, and Wajir.
Vane Kwamboka Omwenga +10 more
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Emerging Leishmania donovani Lineages Associated with Cutaneous Leishmaniasis, Himachal Pradesh, India, 2023 [PDF]
Emerging Infectious DiseasesThe clinical manifestation of leishmaniasis has historically been determined by the Leishmania species involved. However, recent emergence of novel Leishmania lineages has caused atypical pathologies.
Patrick Lypaczewski +7 more
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Leishmania donovani hybridisation and introgression in nature: a comparative genomic investigation.
The Lancet Microbe, 2021 BACKGROUND Leishmaniasis is a neglected tropical disease transmitted by infected sandflies that results in diverse human pathologies contingent on the species of Leishmania. Leishmania donovani causes highly virulent fatal visceral leishmaniasis, whereas
Patrick Lypaczewski, G. Matlashewski
semanticscholar +1 more source
Emerging Infectious Diseases, 2023 Cutaneous leishmaniasis caused by Leishmania major or L. tropica and visceral leishmaniasis caused by L. infantum have been reported in Israel. We collected Phlebotomus spp.
Liora Studentsky +10 more
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Leishmania donovani: an unusual eyelid presentation. [PDF]
Eye (Lond)Rubegni G, Lamberti A, Tosi GM.
europepmc +3 more sources