Results 1 to 10 of about 31,150 (219)

Sphingosine-1-phosphate receptor signaling regulates an ERK1/2-p65 molecular switch in macrophages during <i>Leishmania donovani</i> infection. [PDF]

Front Pharmacol
Leishmania donovani establishes intracellular infection by suppressing macrophage inflammatory responses. Although sphingosine-1-phosphate (S1P) signaling is known to regulate macrophage function, the receptor isotype–specific mechanisms involved during ...
Arish M, Naz F.
europepmc   +2 more sources

Detection of <i>Leishmania donovani</i> Status in Dogs (<i>Canis familiaris,</i> Linnaeus, 1758) in the Karamoja Subregion of Uganda. [PDF]

J Trop Med
To date, the reservoir host for visceral leishmaniasis, a neglected tropical disease caused by Leishmania donovani, is unknown, although studies pointing to dogs, domestic animals, and rodents are emerging.
Kato CD, Musewa A, Okumu TA, Mbuchi M, Atusingwize E, Ankunda I, Tomas SC, Ferrer GP, Matovu B, Muhumuza E, Bachs MP, Figueres JM, Ochieng JR.   +12 more
europepmc   +2 more sources

In vitro antipromastigote activity of decoction and hydrodistillation extracts of Clematis hirsuta leaves against Leishmania donovani and Leishmania aethiopica. [PDF]

BMC Complement Med Ther
Leishmaniasis remains a significant health concern in four eco-epidemiological regions of the world (WHO, 2024). Annually, there are thought to be 700,000 to 1 million new cases of leishmaniasis.
Abebe E, Gelana T, Nigussie H, Ejigu A, Asmamaw Y, Araya D, Hailesilassie W, Tadele M, Sirak B, Mequanente S, Belay G.   +10 more
europepmc   +2 more sources

Evaluation of CD1a immunostaining in the diagnosis of cutaneous leishmaniasis caused by Leishmania donovani in Sri Lanka. [PDF]

Parasitology
Cutaneous leishmaniasis (CL) is a vector-borne parasitic disease, routinely diagnosed by direct light microscopy. The sensitivity of this method is dependent on the number of parasites present in the lesion.
Riyal H, Samaranayake N, Amarathunga P, Munidasa D, Karunaweera N.   +4 more
europepmc   +2 more sources

Direct sequencing of Leishmania donovani from patients in Garissa County, Northern Kenya, reveals a newly emerging intra-specific hybrid genotype. [PDF]

PLoS Negl Trop Dis
IntroductionLeishmaniasis is endemic in many countries, and in Kenya outbreaks of visceral leishmaniasis (VL) commonly occur in Garissa, Isiolo, Marsabit, Turkana, and Wajir.
Omwenga VK, Kimita G, Matoke-Muhia D, Ayieko C, Masakhwe C, Ibrahim MH, Heeren S, Dujardin JC, Monsieurs P, Domagalska MA, Waitumbi J.   +10 more
europepmc   +2 more sources

Emerging Leishmania donovani Lineages Associated with Cutaneous Leishmaniasis, Himachal Pradesh, India, 2023. [PDF]

Emerg Infect Dis
The clinical manifestation of leishmaniasis has historically been determined by the Leishmania species involved. However, recent emergence of novel Leishmania lineages has caused atypical pathologies.
Lypaczewski P, Chauhan Y, Paulini K, Thakur L, Chauhan S, Roy EI, Matlashewski G, Jain M.   +7 more
europepmc   +2 more sources

LmaPA2G4, a Homolog of Human Ebp1, Is an Essential Gene and Inhibits Cell Proliferation in L. major [PDF]

, 2014
We have identified LmaPA2G4, a homolog of the human proliferation-associated 2G4 protein (also termed Ebp1), in aphosphoproteomic screening. Multiple sequence alignment and cluster analysis revealed that LmaPA2G4 is a non-peptidasemember of the M24 ...
Joyce, Michelle V., Morales, Miguel A., Norris Mullins, Brianna, Vacchina, Paola, VanderKolk, Kaitlin   +4 more
core   +35 more sources

Leishmania donovani Transmission Cycle Associated with Human Infection, Phlebotomus alexandri Sand Flies, and Hare Blood Meals, Israel

Emerging Infectious Diseases, 2023
Cutaneous leishmaniasis caused by Leishmania major or L. tropica and visceral leishmaniasis caused by L. infantum have been reported in Israel. We collected Phlebotomus spp.
Liora Studentsky, Laor Orshan, Fouad Akad, Irina Ben Avi, Debora Diaz, Shirly Elbaz, Orly Sagi, Gal Zagron, Lea Valinsky, Maya Davidovich-Cohen, Gad Baneth   +10 more
doaj   +1 more source

Vaccine Development Against Leishmania donovani [PDF]

Frontiers in Immunology, 2012
La leishmaniasis visceral (VL) causada por Leishmania donovani y Leishmania infantum/chagasi representa la segunda enfermedad infecciosa más difícil en todo el mundo, lo que lleva a casi 500.000 nuevos casos y 60.000 muertes al año. La VL zoonótica causada por L.
Amrita Das, Nahid Ali
openaire   +3 more sources

Genetic diversity analysis of Chinese Leishmania isolates and development of L. donovani complex-specific markers by RAPD

BMC Infectious Diseases, 2021
Background Leishmaniasis is one of the most neglected tropical diseases in the world and remains endemic in some underdeveloped regions, including western China.
Dongmei Yuan, Hanxiao Qin, Dali Chen, Jianping Chen   +3 more
doaj   +1 more source