Results 31 to 40 of about 69,891 (211)

L-Asparaginase of Leishmania donovani: Metabolic target and its role in Amphotericin B resistance

International Journal for Parasitology: Drugs and Drug Resistance, 2017
Emergence of Amphotericin B (AmB) resistant Leishmania donovani has posed major therapeutic challenge against the parasite. Consequently, combination therapy aimed at multiple molecular targets, based on proteome wise network analysis has been ...
Jasdeep Singh, Mohd Imran Khan, Shiv Pratap Singh Yadav, Ankit Srivastava, Kislay K. Sinha, Ashish, Pradeep Das, Bishwajit Kundu   +7 more
doaj   +1 more source

Leishmania donovani populations in Eastern Sudan: temporal structuring and a link between human and canine transmission. [PDF]

, 2014
BACKGROUND: Visceral leishmaniasis (VL), caused by the members of the Leishmania donovani complex, has been responsible for devastating VL epidemics in the Sudan.
Baleela, Rania, Kuhls, Katrin, Fitzpatrick, Sinead, Katrin Kuhls, Llewellyn, Martin S, Mauricio, Isabel L, Martin S Llewellyn, Miles, Michael A, Michael A Miles, Rania Baleela, Sinead Fitzpatrick, Gabriele Schönian, Schönian, Gabriele, Isabel L Mauricio, Schönian, Gabriele; https://orcid.org/, Mauricio, Isabel L.; https://orcid.org/, Kuhls, Katrin; https://orcid.org/, Llewellyn, Martin S.; https://orcid.org/, Miles, Michael A.; https://orcid.org/, Baleela, Rania; https://orcid.org/   +19 more
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Genetic diversity of Leishmania donovani that causes cutaneous leishmaniasis in Sri Lanka: a cross sectional study with regional comparisons

BMC Infectious Diseases, 2017
Background Leishmania donovani is the etiological agent of visceral leishmaniasis (VL) in the Indian subcontinent. However, it is also known to cause cutaneous leishmaniasis (CL) in Sri Lanka. Sri Lankan L. donovani differs from other L. donovani strains,
Udeshika Lakmini Kariyawasam, Angamuthu Selvapandiyan, Keshav Rai, Tasaduq Hussain Wani, Kavita Ahuja, Mizra Adil Beg, Hasitha Upendra Premathilake, Narayan Raj Bhattarai, Yamuna Deepani Siriwardena, Daibin Zhong, Guofa Zhou, Suman Rijal, Hira Nakhasi, Nadira D. Karunaweera   +13 more
doaj   +1 more source

Characterization of a Novel Putative S-Adenosylmethionine Decarboxylase-Like Protein from Leishmania donovani. [PDF]

PLoS ONE, 2013
In addition to the S-adenosylmethionine decarboxylase (AD) present in all organisms, trypanosomatids including Leishmania spp. possess an additional copy, annotated as the putative S-adenosylmethionine decarboxylase-like proenzyme (ADL).
Saurabh Pratap Singh, Pragati Agnihotri, J Venkatesh Pratap   +2 more
doaj   +1 more source

Incidence of symptomatic and asymptomatic Leishmania donovani infections in high-endemic foci in India and Nepal: a prospective study. [PDF]

, 2011
Incidence of Leishmania donovani infection and Visceral Leishmaniasis (VL) was assessed in a prospective study in Indian and Nepalese high-endemic villages. DAT-seroconversion was used as marker of incident infection in 3 yearly surveys.
Ostyn Bart, Singh Shri Prakash, Khanal, Basudha, Sundar Shyam, Gidwani, Kamlesh, Picado, Albert, Boelaert Marleen, Singh, Shri Prakash, Sundar, Shyam, Rijal Suman, Boelaert, Marleen, Chappuis François, Gidwani Kamlesh, Bart Ostyn, Basudha Khanal, Shyam Sundar, Picado Albert, Albert Picado, Marleen Boelaert, Shri Prakash Singh, Kamlesh Gidwani, François Chappuis, Rijal, Suman, Ostyn, Bart, Chappuis, François, Suman Rijal, Khanal Basudha   +26 more
core   +2 more sources

Genetic diversity in the Leishmania donovani complex. [PDF]

The Leishmania donovani complex comprises four described species: L. donovani, L. archibaldi, L. infantum and L. chagasi. L. chagasi is the only New World species and has been considered similar to L.
Mauricio, Isabel Larguinho
core   +1 more source

Comparison of visceral leishmaniasis diagnostic antigens in African and Asian Leishmania donovani reveals extensive diversity and region-specific polymorphisms. [PDF]

, 2013
BACKGROUND: Visceral leishmaniasis (VL), caused by infection with Leishmania donovani complex, remains a major public health problem in endemic regions of South Asia, East Africa, and Brazil. If untreated, symptomatic VL is usually fatal.
Bhattacharyya, T., Miles, M. A., Miles, Michael A, Michael A Miles, Bhattacharyya, Tapan, Boelaert, M., Boelaert, Marleen, Tapan Bhattacharyya, Marleen Boelaert, Boelaert Marleen, Miles Michael A., Bhattacharyya Tapan   +11 more
core   +1 more source

Molecular docking of daunorubicin and etoposide drugs against Leishmania donovani: A theoretical study

Journal of Vector Borne Diseases
Background & objectives: The human blood parasite Leishmania donovani causes visceral leishmaniasis or grayish discoloration of the skin (black fever/kala-azar). Antitumor drugs such as daunorubicin and etoposide can help to treat such diseases.
Afnan Mohammed Shakoori, Fatemah Alhakami, Ghadir Sindi, Areej Yahya Alyahyawi, Rasha Abdullah Alhazzaa   +4 more
doaj   +1 more source

Natural infection of the opossum Didelphis albiventris (Marsupialia, Didelphidae) with Leishmania donovani, in Brazil

Memorias do Instituto Oswaldo Cruz, 1984
An opossum, Didelphis albiventris, from Jacobina, bahia State, was found naturally infected with Leishmania donovani, being the first non-canid wild mammal to be detected with agent of kala-azar in the New World.Um gambá, Didelphis albiventris, de ...
Ítalo A. Sherlock, José Carlos Miranda, Moysés Sadigursky, Gabriel Grimaldi Júnior   +3 more
doaj   +1 more source

The Leishmania donovani complex: genotypes of five metabolic enzymes (ICD, ME, MPI, G6PDH, and FH), new targets for multilocus sequence typing.

, 2007
Flagellates of the Leishmania donovani complex are causative agents of human cutaneous and visceral leishmaniasis. The complex is comprised of L. donovani, Leishmania infantum and Leishmania archibaldi, although the latter is not now considered to be a ...
Jirků, Milan, Mauricio, Isabel L, Zemanová, Eva, Lukes, Julius, Miles, Michael A, Horák, Ales   +5 more
core   +1 more source