Results 31 to 40 of about 13,658 (180)
Parasites & Vectors, 2018 Background Leishmania development in sand flies is confined to the alimentary tract and is closely connected with blood meal digestion. Previously, it has been published that activities of sand fly midgut proteases are harmful to Leishmania, especially ...
Katerina Pruzinova +5 more
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Leishmania -infected macrophages release extracellular vesicles that can promote lesion development
Life Science Alliance, 2020 Macrophages infected with Leishmania donovani release extracellular vesicles that are composed of parasite and host-derived molecules that have the potential to induce vascular changes in tissues.
Anna Gioseffi +6 more
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Emerging Infectious DiseasesCutaneous leishmaniasis is atypical in Sri Lanka because Leishmania donovani, which typically causes visceral disease, is the causative agent. The origins of recently described hybrids between L. donovani and other Leishmania spp.
Hermali Silva +8 more
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The metabolism of Leishmania donovani in culture [PDF]
Biochemical Journal, 1954 Lei8hnmnia donovani, the organism causing visceral leishmaniasis, is a small, round or ovoid body measuring 2-5 g. in diameter, which occurs exclusively within cells of the reticulo-endothelial system of its mammalian host. In culture, or in the insect vector, the parasite exists in a flagellate leptomonad form. In the case of L. tropica in culture, it
S, CROWTHER, J D, FULTON, L P, JOYNER
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Cathepsin B gene disruption induced Leishmania donovani proteome remodeling implies cathepsin B role in secretome regulation. [PDF]
PLoS ONE, 2013 Leishmania cysteine proteases are potential vaccine candidates and drug targets. To study the role of cathepsin B cysteine protease, we have generated and characterized cathepsin B null mutant L. donovani parasites. L.
Teklu Kuru Gerbaba, Lashitew Gedamu
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مجلة بغداد للعلوم, 2021 Antibacterial activity of CNSs against Staphylococcus aureus and Escherichia coli was estimated. Higher inhibition zone of 18 mm and 20 mm were observed against S.
Ali Taha +3 more
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Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva +10 more
wiley +1 more source
Frontiers in Immunology, 2021 Visceral leishmaniasis (VL) is a fatal parasitic disease if untreated. Treatment options of VL diminish due to emerging drug resistance. Although the principal host cells for the multiplication of Leishmania are macrophages, neutrophils are the first ...
Mareike Ohms +8 more
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Tropical Medicine &International Health, EarlyView.ABSTRACT Visceral leishmaniasis (VL) is a human neglected tropical disease in which dogs participate as reservoirs of the etiological agent Leishmania chagasi. The identification of infected dogs is important to the control of VL, and recombinant proteins are strong antigen candidates for canine visceral leishmaniasis (CVL) serodiagnosis. In this work,
Thaís Viana Fialho Martins +12 more
wiley +1 more source
Proteomic analysis of the secretome of Leishmania donovani [PDF]
Genome Biology, 2008 Abstract Background Leishmania and other intracellular pathogens have evolved strategies that support invasion and persistence within host target cells. In some cases the underlying mechanisms involve the export of virulence factors into the host cell cytosol.
Silverman, J M +6 more
openaire +3 more sources