Results 21 to 30 of about 65,283 (218)
Elucidation of DNA Primase as a Drug Target in Leishmania donovani: Structure-Guided Inhibitor Identification and Biochemical Validation. [PDF]
Chem Biol Drug DesStructure‐guided and biochemical analyses indicate that DNA primase of Leishmania donovani represents a potential therapeutic target, as repurposed compounds, particularly Pritelivir, demonstrate marked inhibitory effects accompanied by reduced parasite proliferation, replication, and altered cellular morphology in in vitro and cell‐based studies ...
Bhowmik D, Sharma A, Arya RP, Kumar D.
europepmc +2 more sources
Biochimica et Biophysica Acta - Biomembranes, 2021 Visceral leishmaniasis is one of the neglected tropical diseases caused by an intracellular parasite, Leishmania donovani. Drug resistance, adverse side effects and long treatment regimes are important limitations in achieving the effective elimination ...
Vivek Kumar, A. Chugh
semanticscholar +1 more source
LEISHMANIA DONOVANI IN THE PERIPHERAL BLOOD [PDF]
Journal of Experimental Medicine, 1923 1. The effect of human red cells and serum on the growth of Leishmania donovani has been studied and a blood culture method devised, based on these findings. 2. The distribution of blood platelets and of the different varieties of leucocytes in the strata of centrifugalized diluted blood has been investigated, and also the distribution ...
C W, Young, H M, Van Sant
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BMC Infectious Diseases, 2021 Background Leishmaniasis is one of the most neglected tropical diseases in the world and remains endemic in some underdeveloped regions, including western China.
Dongmei Yuan +3 more
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HAT2 mediates histone H4K4 acetylation and affects micrococcal nuclease sensitivity of chromatin in Leishmania donovani. [PDF]
PLoS ONE, 2017 Histone post-translational modifications (PTMs) such as acetylation and methylation are known to affect chromatin higher order structures. Primary targets of these modifications include basic residues present at N-terminus tail region of core histones ...
Pravin K Jha +4 more
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Scientific Reports, 2020 Leishmaniasis, a major neglected tropical disease, affects millions of individuals worldwide. Among the various clinical forms, visceral leishmaniasis (VL) is the deadliest.
P. K. Pramanik +3 more
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Emerging Infectious Diseases, 2020 We conducted a molecular study of parasite sequences from a cohort of cutaneous leishmaniasis patients in Himachal Pradesh, India. Results revealed atypical cutaneous disease caused by Leishmania donovani parasites. L. donovani variants causing cutaneous
Lovlesh Thakur +9 more
semanticscholar +1 more source
Comprehensive proteomic analysis of autophagosomes derived from Leishmania-infected macrophages.
PLoS ONE, 2023 Recently, autophagy has been implicated as a host defense mechanism against intracellular pathogens. On the other hand, certain intracellular pathogens such as Leishmania can manipulate the host's autophagy to promote their survival.
Devki Nandan +5 more
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The Leishmania donovani species complex: a new insight into taxonomy.
International Journal of Parasitology, 2020 Among the 20 or so Leishmania spp. described as pathogenic for humans, those of the Leishmania donovani complex are the exclusive causative agents of systemic and fatal visceral leishmaniasis.
A. Fernández-Arévalo +10 more
semanticscholar +1 more source
Microbiology Spectrum, 2022 Infection with Leishmania donovani reduces cellular cholesterol and thus deprives the host cells by inhibiting its synthesis and uptake. Changes in cholesterol levels increase the chance of attachment and internalization of L. donovani in macrophages (Mϕ)
Satya Prakash, Ambak Kumar Rai
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