Results 41 to 50 of about 69,891 (211)
Parasites & Vectors, 2018 Background Leishmania development in sand flies is confined to the alimentary tract and is closely connected with blood meal digestion. Previously, it has been published that activities of sand fly midgut proteases are harmful to Leishmania, especially ...
Katerina Pruzinova +5 more
doaj +1 more source
Leishmania -infected macrophages release extracellular vesicles that can promote lesion development
Life Science Alliance, 2020 Macrophages infected with Leishmania donovani release extracellular vesicles that are composed of parasite and host-derived molecules that have the potential to induce vascular changes in tissues.
Anna Gioseffi +6 more
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The metabolism of Leishmania donovani in culture [PDF]
Biochemical Journal, 1954 Lei8hnmnia donovani, the organism causing visceral leishmaniasis, is a small, round or ovoid body measuring 2-5 g. in diameter, which occurs exclusively within cells of the reticulo-endothelial system of its mammalian host. In culture, or in the insect vector, the parasite exists in a flagellate leptomonad form. In the case of L. tropica in culture, it
S, CROWTHER, J D, FULTON, L P, JOYNER
openaire +2 more sources
Emerging Infectious DiseasesCutaneous leishmaniasis is atypical in Sri Lanka because Leishmania donovani, which typically causes visceral disease, is the causative agent. The origins of recently described hybrids between L. donovani and other Leishmania spp.
Hermali Silva +8 more
doaj +1 more source
Interleukin‐12: Central Roles in Immune Regulation and Disease Therapy
Immunology &Cell Biology, EarlyView.IL‐12 levels are tightly regulated to balance effective protective immunity against infections and cancer with the risk of excessive inflammation and autoimmune disease. Both insufficient and excessive IL‐12 activity can therefore be detrimental, highlighting the importance of precisely controlling its production and signaling. ABSTRACT Interleukin‐12 (
Anthi Psoma, Geert van den Bogaart
wiley +1 more source
Cathepsin B gene disruption induced Leishmania donovani proteome remodeling implies cathepsin B role in secretome regulation. [PDF]
PLoS ONE, 2013 Leishmania cysteine proteases are potential vaccine candidates and drug targets. To study the role of cathepsin B cysteine protease, we have generated and characterized cathepsin B null mutant L. donovani parasites. L.
Teklu Kuru Gerbaba, Lashitew Gedamu
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Systemic treatment of cutaneous leishmaniasis: A systematic review and meta‐analysis
Journal of the European Academy of Dermatology and Venereology, EarlyView.This systematic review and meta‐analysis assessed systemic treatments for cutaneous leishmaniasis across 83 studies and 4603 patients. Treatment efficacies of meglumine antimoniate, miltefosine, azoles, pentamidine, and liposomal amphotericin B varied by region and species. Miltefosine showed consistent evidence across multiple settings.
Maximilian Egg +10 more
wiley +1 more source
Medical and Veterinary Entomology, EarlyView.Leishmania DNA was confirmed in phlebotomine sand flies collected in Slovenia. Molecular analyses confirmed Leishmania infantum in a pool of Phlebotomus neglectus females with a high parasite DNA load. The findings indicate potential conditions for local transmission and support continued entomological surveillance.
Sara Zupan +4 more
wiley +1 more source
Cell Reports, 2016 Participation of B cells in the immune response by various antibody-independent mechanisms has recently been uncovered. B cells producing cytokines have been described for several infections and appear to regulate the adaptive immune response.
Sasha Silva-Barrios +6 more
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Archives of Public Health, 2023 Background Ethiopia is one of the top 10 countries in the world where 90% visceral leishmaniasis cases are reported. Metema-Humera lowlands are the most important foci in Ethiopia. Blood transfusion in visceral leishmaniasis endemic foci in Ethiopia does
Iyasu Melkie +3 more
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