Results 41 to 50 of about 13,690 (178)
Cell Reports, 2016 Participation of B cells in the immune response by various antibody-independent mechanisms has recently been uncovered. B cells producing cytokines have been described for several infections and appear to regulate the adaptive immune response.
Sasha Silva-Barrios +6 more
doaj +1 more source
Archives of Public Health, 2023 Background Ethiopia is one of the top 10 countries in the world where 90% visceral leishmaniasis cases are reported. Metema-Humera lowlands are the most important foci in Ethiopia. Blood transfusion in visceral leishmaniasis endemic foci in Ethiopia does
Iyasu Melkie +3 more
doaj +1 more source
مجلة بغداد للعلوم, 2021 Antibacterial activity of CNSs against Staphylococcus aureus and Escherichia coli was estimated. Higher inhibition zone of 18 mm and 20 mm were observed against S.
Ali Taha +3 more
doaj +1 more source
Adenine and adenosine salvage in Leishmania donovani [PDF]
Molecular and Biochemical Parasitology, 2013 6-aminopurine metabolism in Leishmania is unique among trypanosomatid pathogens since this genus expresses two distinct routes for adenine salvage: adenine phosphoribosyltransferase (APRT) and adenine deaminase (AAH). To evaluate the relative contributions of APRT and AAH, adenine salvage was evaluated in Δaprt, Δaah, and Δaprt/Δaah null mutants of L ...
Jan M, Boitz, Buddy, Ullman
openaire +2 more sources
Tropical Medicine &International Health, Volume 31, Issue 8, Page 1057-1065, August 2026.ABSTRACT Visceral leishmaniasis (VL) is a human neglected tropical disease in which dogs participate as reservoirs of the etiological agent Leishmania chagasi. The identification of infected dogs is important to the control of VL, and recombinant proteins are strong antigen candidates for canine visceral leishmaniasis (CVL) serodiagnosis. In this work,
Thaís Viana Fialho Martins +12 more
wiley +1 more source
CRISPR-Cas9-Mediated Genome Editing in
mBio, 2015 The prokaryotic CRISPR (clustered regularly interspaced short palindromic repeat)-Cas9, an RNA-guided endonuclease, has been shown to mediate efficient genome editing in a wide variety of organisms.
Wen-Wei Zhang, Greg Matlashewski
doaj +1 more source
Carbon Dioxide Assimilation by Leishmania donovani [PDF]
Nature, 1960 WHILE studying the glucose metabolism of Leishmania donovani, the protozoan organism causing visceral leishmaniasis, it has been found that cell suspensions of this organism in a saline-bicarbonate buffer containing glucose can assimilate, a measurable amount of carbon dioxide along with the formation of different acidic end products1.
A N, CHATTERJEE, J J, GHOSH
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The FASEB Journal, Volume 40, Issue 13, 15 July 2026.Impairment of hepato‐intestinal homeostasis triggered by ST2 deficiency during T. cruzi infection. Within the splenic compartment, immune dysregulation is marked by a robust pro‐inflammatory polarization of the T‐cell landscape. In the liver, ST2 deficiency is associated with hepatocellular injury, increased parasite burden, and hyperalbuminemia ...
Marcelo Eduardo Cardozo +22 more
wiley +1 more source
Glutamine supplementation improves the efficacy of miltefosine treatment for visceral leishmaniasis.
PLoS Neglected Tropical Diseases, 2020 BackgroundThe disturbance of host metabolic pathways by Leishmania parasites has crucial consequences for the activation status of immune cells and the outcome of infection.
Carolina Ferreira +11 more
doaj +1 more source
ChemMedChem, Volume 21, Issue 13, 14 July 2026.A series of 5‐nitroimidazole‐1,2,3‐triazole hybrids was synthesised and evaluated for antitrypanosomatid activity to assess their potential as treatments against leishmaniasis and trypanosomiasis. No notable in vitro activity against Leishmania was detected.
Liandi Ferreira +4 more
wiley +1 more source