Results 41 to 50 of about 65,283 (218)

Identification of internalin-A-like virulent proteins in Leishmania donovani

Parasites & Vectors, 2016
Background An active immune surveillance and a range of barriers to infection allow the host to effectively eliminate microbial pathogens. However, pathogens may use diverse strategies to subdue such host defences. For instance, one such mechanism is the
Ishita Mukherjee, Abhijit Chakraborty, Saikat Chakrabarti   +2 more
doaj   +1 more source

Haplotype selection as an adaptive mechanism in the protozoan pathogen Leishmania donovani

Nature Ecology & Evolution, 2017
The parasite Leishmania donovani causes a fatal disease termed visceral leishmaniasis. The process through which the parasite adapts to environmental change remains largely unknown.
Pablo Prieto Barja, P. Pescher, G. Bussotti, F. Dumetz, H. Imamura, D. Kedra, M. Domagalska, Victor Chaumeau, H. Himmelbauer, M. Pagès, Y. Sterkers, J. Dujardin, Cédric Notredame, G. F. Späth   +13 more
semanticscholar   +1 more source

Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani

ACS Infectious Diseases, 2018
Visceral leishmaniasis (VL), caused by the protozoan parasites Leishmania donovani and L. infantum, is responsible for ∼30 000 deaths annually. Available treatments are inadequate, and there is a pressing need for new therapeutics. N-Myristoyltransferase
Victoriano Corpas-Lopez, S. Moniz, M. Thomas, Richard J. Wall, L. S. Torrie, Dorothea Zander-Dinse, M. Tinti, S. Brand, L. Stojanovski, Sujatha Manthri, I. Hallyburton, F. Zuccotto, P. Wyatt, M. De Rycker, D. Horn, M. Ferguson, J. Clos, K. Read, A. Fairlamb, I. Gilbert, S. Wyllie   +20 more
semanticscholar   +1 more source

Real-time PCR in detection and quantitation of Leishmania donovani for the diagnosis of Visceral Leishmaniasis patients and the monitoring of their response to treatment

PLoS ONE, 2017
Sustained elimination of Visceral Leishmaniasis (VL) requires the reduction and control of parasite reservoirs to minimize the transmission of Leishmania donovani infection.
F. Hossain, P. Ghosh, Md Anik Ashfaq Khan, M. Duthie, Aarthy C. Vallur, Alessandro Picone, R. F. Howard, S. Reed, D. Mondal   +8 more
semanticscholar   +1 more source

Characterization of a Novel Putative S-Adenosylmethionine Decarboxylase-Like Protein from Leishmania donovani. [PDF]

PLoS ONE, 2013
In addition to the S-adenosylmethionine decarboxylase (AD) present in all organisms, trypanosomatids including Leishmania spp. possess an additional copy, annotated as the putative S-adenosylmethionine decarboxylase-like proenzyme (ADL).
Saurabh Pratap Singh, Pragati Agnihotri, J Venkatesh Pratap   +2 more
doaj   +1 more source

Leishmania donovani Internalizes into Host Cells via Caveolin-mediated Endocytosis

Scientific Reports, 2019
Leishmania donovani is an intracellular protozoan parasite that causes visceral leishmaniasis, a major cause of mortality and morbidity worldwide. The host plasma membrane serves as the portal of entry for Leishmania to gain access to the cellular ...
G. Kumar, Joyshree Karmakar, C. Mandal, A. Chattopadhyay   +3 more
semanticscholar   +1 more source

Molecular docking of daunorubicin and etoposide drugs against Leishmania donovani: A theoretical study

Journal of Vector Borne Diseases
Background & objectives: The human blood parasite Leishmania donovani causes visceral leishmaniasis or grayish discoloration of the skin (black fever/kala-azar). Antitumor drugs such as daunorubicin and etoposide can help to treat such diseases.
Afnan Mohammed Shakoori, Fatemah Alhakami, Ghadir Sindi, Areej Yahya Alyahyawi, Rasha Abdullah Alhazzaa   +4 more
doaj   +1 more source

Natural infection of the opossum Didelphis albiventris (Marsupialia, Didelphidae) with Leishmania donovani, in Brazil

Memorias do Instituto Oswaldo Cruz, 1984
An opossum, Didelphis albiventris, from Jacobina, bahia State, was found naturally infected with Leishmania donovani, being the first non-canid wild mammal to be detected with agent of kala-azar in the New World.Um gambá, Didelphis albiventris, de ...
Ítalo A. Sherlock, José Carlos Miranda, Moysés Sadigursky, Gabriel Grimaldi Júnior   +3 more
doaj   +1 more source

A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence

Scientific Reports, 2018
Leishmania donovani is responsible for visceral leishmaniasis, a neglected and lethal parasitic disease with limited treatment options and no vaccine. The study of L.
Patrick Lypaczewski, Johanna Hoshizaki, Wen-Wei Zhang, Laura-Isobel McCall, John Torcivia-Rodriguez, V. Simonyan, A. Kaur, K. Dewar, G. Matlashewski   +8 more
semanticscholar   +1 more source

Leishmania mortality in sand fly blood meal is not species-specific and does not result from direct effect of proteinases

Parasites & Vectors, 2018
Background Leishmania development in sand flies is confined to the alimentary tract and is closely connected with blood meal digestion. Previously, it has been published that activities of sand fly midgut proteases are harmful to Leishmania, especially ...
Katerina Pruzinova, Jovana Sadlova, Jitka Myskova, Tereza Lestinova, Jozef Janda, Petr Volf   +5 more
doaj   +1 more source