Results 51 to 60 of about 31,150 (219)

Cathepsin B gene disruption induced Leishmania donovani proteome remodeling implies cathepsin B role in secretome regulation. [PDF]

PLoS ONE, 2013
Leishmania cysteine proteases are potential vaccine candidates and drug targets. To study the role of cathepsin B cysteine protease, we have generated and characterized cathepsin B null mutant L. donovani parasites. L.
Teklu Kuru Gerbaba, Lashitew Gedamu
doaj   +1 more source

Leishmania donovaniand Cutaneous Leishmaniasis, Sri Lanka [PDF]

Emerging Infectious Diseases, 2007
To investigate the relationship of cutaneous leishmaniasis isolates from Sri Lanka to known species, we performed DNA sequencing and microsatellite analyses. We identified Leishmania donovani as the agent of Sri Lanka cutaneous leishmaniasis and showed that these parasites are closely related to those causing visceral leishmaniasis in the Indian ...
Siriwardana, H V Yamuna D, Noyes, Harry A, Beeching, Nicholas J, Chance, Michael L, Karunaweera, Nadira D, Bates, Paul A   +5 more
openaire   +3 more sources

Recombinant LPG3 Protein From Leishmania chagasi as an Antigen for the Diagnosis of Canine Visceral Leishmaniasis

Tropical Medicine &International Health, EarlyView.
ABSTRACT Visceral leishmaniasis (VL) is a human neglected tropical disease in which dogs participate as reservoirs of the etiological agent Leishmania chagasi. The identification of infected dogs is important to the control of VL, and recombinant proteins are strong antigen candidates for canine visceral leishmaniasis (CVL) serodiagnosis. In this work,
Thaís Viana Fialho Martins, Anna Cláudia Alves de Souza, Bianca Meireles Miranda, Ronny Francisco de Souza, Daniel Silva Sena Bastos, Neverton José Silva Ferreira, Tiago Antônio de Oliveira Mendes, Celeste da Silva Freitas de Souza, George Luiz Lins Machado‐Coelho, Maria Terezinha Bahia, Leandro Licursi de Oliveira, Juliana Lopes Rangel Fietto, Eduardo de Almeida Marques‐da‐Silva   +12 more
wiley   +1 more source

Evaluation of the Cutaneous Immunological Milieu Before and After Treatment With Meglumine Antimoniate in Dogs Naturally Affected by Leishmaniosis due to Leishmania infantum

Veterinary Dermatology, EarlyView.
Background: Canine leishmaniosis (CanL) is a zoonotic disease of variable severity. The typical immune response is driven by an exaggerated humoral immune response. Protective immunity is mediated by pro‐inflammatory cytokines that enhance macrophage leishmanicidal activity. Objective: To evaluate the cutaneous and the systemic immune responses as well
M. Platenik, A. Di Loria, L. Archer, M. Saridomichelakis, A. S. Benvenuto, D. Santoro   +5 more
wiley   +1 more source

Leishmania tarentolae: taxonomic classification and its application as a promising biotechnological expression host

, 2019
In this review, we summarize the current knowledge concerning the eukaryotic protozoan parasite Leishmania tarentolae, with a main focus on its potential for biotechnological applications.
Klatt, S., Konthur, Z., Maslov, D., Simpson, L.   +3 more
core   +1 more source

CRISPR-Cas9-Mediated Genome Editing in Leishmania donovani

mBio, 2015
The prokaryotic CRISPR (clustered regularly interspaced short palindromic repeat)-Cas9, an RNA-guided endonuclease, has been shown to mediate efficient genome editing in a wide variety of organisms.
Wen-Wei Zhang, Greg Matlashewski
doaj   +1 more source

Asymptomatic Leishmania donovani infection and associated factors among blood donors attending at Metema district Blood Bank, Northwest Ethiopia: a cross- sectional study

Archives of Public Health, 2023
Background Ethiopia is one of the top 10 countries in the world where 90% visceral leishmaniasis cases are reported. Metema-Humera lowlands are the most important foci in Ethiopia. Blood transfusion in visceral leishmaniasis endemic foci in Ethiopia does
Iyasu Melkie, Mulat Yimer, Getaneh Alemu, Banchamlak Tegegne   +3 more
doaj   +1 more source

Unravelling the biochemical aspects of the interaction between ticks and Leishmania using a tick cell line

Medical and Veterinary Entomology, Volume 40, Issue 2, Page 350-359, June 2026.
Leishmania infantum propagated in IDE8 tick cell line in vitro. L. infantum reduces tick cell viability and induces reactive oxygen species production. Lipidic profile of IDE8 tick cell line is altered during Leishmania infection. Abstract Leishmaniasis comprises a group of vector‐borne neglected tropical diseases caused by species of the obligatory ...
Beatriz Filgueiras Silvestre, Karoline dos Anjos Lima, Fernanda de Paula Pepino, Daniela Cosentino‐Gomes, Adivaldo Fonseca, Lesley Bell‐Sakyi, Georgia Correa Atella, Lucia H. Pinto‐da‐Silva   +7 more
wiley   +1 more source

Innate Immune B Cell Activation by Leishmania donovani Exacerbates Disease and Mediates Hypergammaglobulinemia

Cell Reports, 2016
Participation of B cells in the immune response by various antibody-independent mechanisms has recently been uncovered. B cells producing cytokines have been described for several infections and appear to regulate the adaptive immune response.
Sasha Silva-Barrios, Mélina Smans, Claudia U. Duerr, Salman T. Qureshi, Jörg H. Fritz, Albert Descoteaux, Simona Stäger   +6 more
doaj   +1 more source

Structural basis of secreted acid phosphatase polymerization in the Leishmania parasite

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Enzymes that assemble into filaments typically transition between protomeric and polymeric states in response to cellular conditions. In contrast, the secreted acid phosphatase (SAP) of Leishmania, one of the most abundant extracellular glycoproteins produced by the parasite and regarded as a major virulence factor in the neglected tropical ...
Priyanka Bose, Irit Dahan, Alexander Upcher, Ran Zalk, Iris Grossman‐Haham   +4 more
wiley   +1 more source