Results 51 to 60 of about 65,283 (218)

Leishmania -infected macrophages release extracellular vesicles that can promote lesion development

Life Science Alliance, 2020
Macrophages infected with Leishmania donovani release extracellular vesicles that are composed of parasite and host-derived molecules that have the potential to induce vascular changes in tissues.
Anna Gioseffi, Tim Hamerly, Kha Van, Naixin Zhang, Rhoel R Dinglasan, Phillip A Yates, Peter E Kima   +6 more
doaj   +1 more source

Ly6Chi inflammatory monocytes promote susceptibility to Leishmania donovani infection

Scientific Reports, 2017
Ly6Chi inflammatory monocytes (iMO) are critical for host defense against toxoplasmosis and malaria but their role in leishmaniasis is unclear. In this study, we report a detrimental role of Ly6Chi iMOs in visceral leishmaniasis (VL) caused by Leishmania
César A. Terrazas, Sanjay Varikuti, S. Oghumu, H. Steinkamp, N. Ardic, Jennifer Kimble, H. Nakhasi, A. Satoskar   +7 more
semanticscholar   +1 more source

The metabolism of Leishmania donovani in culture [PDF]

Biochemical Journal, 1954
Lei8hnmnia donovani, the organism causing visceral leishmaniasis, is a small, round or ovoid body measuring 2-5 g. in diameter, which occurs exclusively within cells of the reticulo-endothelial system of its mammalian host. In culture, or in the insect vector, the parasite exists in a flagellate leptomonad form. In the case of L. tropica in culture, it
S, CROWTHER, J D, FULTON, L P, JOYNER
openaire   +2 more sources

Autochthonous Leishmaniasis Caused by Leishmania tropica, Identified by Using Whole-Genome Sequencing, Sri Lanka

Emerging Infectious Diseases
Cutaneous leishmaniasis is atypical in Sri Lanka because Leishmania donovani, which typically causes visceral disease, is the causative agent. The origins of recently described hybrids between L. donovani and other Leishmania spp.
Hermali Silva, Tiago R. Ferreira, Kajan Muneeswaran, Sumudu R. Samarasinghe, Eliza V.C. Alves-Ferreira, Michael E. Grigg, Naduviladath V. Chandrasekharan, David L. Sacks, Nadira D. Karunaweera   +8 more
doaj   +1 more source

Deciphering the interplay between cysteine synthase and thiol cascade proteins in modulating Amphotericin B resistance and survival of Leishmania donovani under oxidative stress

Redox Biology, 2017
Leishmania donovani is the causative organism of the neglected human disease known as visceral leishmaniasis which is often fatal, if left untreated.
Kuljit Singh, V. Ali, K. Pratap Singh, P. Gupta, S. Suman, A. K. Ghosh, S. Bimal, K. Pandey, P. Das   +8 more
semanticscholar   +1 more source

Carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani chagasi are inhibited by benzoxaboroles

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
A series of 6-substituted ureido- and thioureido-benzoxaboroles were investigated as inhibitors of carbonic anhydrases from Trypanosoma cruzi (TcCA), and Leishmania donovani chagasi (LdcCA). Both enzymes were inhibited by benzoxaboroles in the micromolar
A. Nocentini, Roberta Cadoni, P. Dumy, C. Supuran, Jean-Yves Winum   +4 more
semanticscholar   +1 more source

Conserved Asp233–Asp246 hydrogen bond modulates active site dynamics in class A β‐lactamases

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Rigid enzymes catalyze chemical reactions by stabilizing the transition state through a specific conformation. Catalytic residues are precisely positioned, and enzyme dynamics are kept to a minimum. It is thought that conserved residues around the active site (second‐shell residues) play a crucial role in positioning catalytic residues. Asp233
Cristina V. Lopez‐Gallego, Monika Timmer, Jocelyne Vreede, Marcellus Ubbink   +3 more
wiley   +1 more source

Cathepsin B gene disruption induced Leishmania donovani proteome remodeling implies cathepsin B role in secretome regulation. [PDF]

PLoS ONE, 2013
Leishmania cysteine proteases are potential vaccine candidates and drug targets. To study the role of cathepsin B cysteine protease, we have generated and characterized cathepsin B null mutant L. donovani parasites. L.
Teklu Kuru Gerbaba, Lashitew Gedamu
doaj   +1 more source

Characterisation of Casein Kinase 1.1 in Leishmania donovani Using the CRISPR Cas9 Toolkit

BioMed Research International, 2017
The recent adaptation of CRISPR Cas9 genome editing to Leishmania spp. has opened a new era in deciphering Leishmania biology. The method was recently improved using a PCR-based CRISPR Cas9 approach, which eliminated the need for cloning.
Daniel Martel, T. Beneke, E. Gluenz, G. F. Späth, N. Rachidi   +4 more
semanticscholar   +1 more source

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 10, Page 1686-1701, October 2026.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva, Monique Mantovani, Maria E. S. D. Lino, Aline O. Albuquerque, João H. M. da Silva, Ronaldo A. P. Nagem, Adriana L. Rojas, Geraldo R. Sartori, Eduardo Horjales, David Campbell, Otavio H. Thiemann   +10 more
wiley   +1 more source