Results 71 to 80 of about 69,891 (211)

Paromomycin: Uptake and resistance in Leishmania donovani [PDF]

Molecular and Biochemical Parasitology, 2009
Paromomycin is currently in phase IV clinical trials against leishmaniasis. In the present work we elucidate the effect and mechanism of uptake of paromomycin in Leishmania donovani. The in vitro sensitivities of both promastigotes and amastigotes were determined to this aminoglycoside. Association of paromomycin with L.
Anupam, Jhingran, Bhavna, Chawla, Shailendra, Saxena, Michael Peter, Barrett, Rentala, Madhubala   +4 more
openaire   +2 more sources

Peptide‐Enabled Nanoplatforms for Malaria and Leishmaniasis: From Intracellular Targeting to Translational Diagnostic Perspectives

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
Peptide‐enabled nanoplatforms offer multifunctional strategies for the treatment and diagnosis of malaria and leishmaniasis. Liposomal, polymeric, and metallic nanocarriers, together with cell‐penetrating peptides and parasite‐derived mimotopes, can improve targeted drug delivery, stability, bioavailability, and intracellular localization.
Christian S. Carnero Canales, Ana Clara Lunardi Yagi, Túlio Custódio Reis, Jessica Ingrid Cazorla, Jade Rojas Villar, Marcia A. Graminha, Roxana Yesenia Pastrana Alta, Fernando Rogério Pavan   +7 more
wiley   +1 more source

Molecular approaches for a better understanding of the epidemiology and population genetics of Leishmania. [PDF]

, 2010
Molecular approaches are being used increasingly for epidemiological studies of visceral and cutaneous leishmaniases. Several molecular markers resolving genetic differences between Leishmania parasites at species and strain levels have been developed to
Kuhls, K, Schönian, G, Mauricio, IL, I. L. MAURICIO, K. KUHLS, G. SCHÖNIAN   +5 more
core   +1 more source

The development of L. major, L. donovani and L. martiniquensis, Leishmania currently emerging in Europe, in the sand fly species Phlebotomus perniciosus and P. tobbi.

PLoS Neglected Tropical Diseases
BackgroundSeveral new species of Leishmania have recently emerged in Europe, probably as the result of global changes and increased human migration from endemic areas.
Jovana Sadlova, Anna Hoskova, Barbora Vojtkova, Tomas Becvar, Petr Volf   +4 more
doaj   +1 more source

Significantly lower anti-Leishmania IgG responses in Sudanese versus Indian visceral leishmaniasis.

PLoS Neglected Tropical Diseases, 2014
BackgroundVisceral leishmaniasis (VL), a widely distributed systemic disease caused by infection with the Leishmania donovani complex (L. donovani and L. infantum), is almost always fatal if symptomatic and untreated.
Tapan Bhattacharyya, Duncan E Bowes, Sayda El-Safi, Shyam Sundar, Andrew K Falconar, Om Prakash Singh, Rajiv Kumar, Osman Ahmed, Marleen Boelaert, Michael A Miles   +9 more
doaj   +1 more source

Beyond the Active Site: First‐In‐Class Leishmania Infantum Trypanothione Reductase Dimerization Disruptors as Antileishmanial Leads

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
This review outlines a pioneering strategy to inhibit Leishmania infantum trypanothione reductase by disrupting its dimer interface. From peptides to small‐molecule proteomimetics, multiple chemotypes achieved potent enzymatic inhibition and notable cellular antileishmanial activity, highlighting a new therapeutic paradigm.
María‐José Camarasa, Miguel Maldonado, Alvaro de la Cruz‐Potenciano, Sonia de Castro   +3 more
wiley   +1 more source

Tuberculosis in Sudan: A Comprehensive Narrative Review of Epidemiological Trends, Diagnosis, Drug Resistance, Challenges, and Data Gaps

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims This narrative review aims to provide a comprehensive overview of tuberculosis (TB) in Sudan, focusing on prevalence, drug resistance patterns, and associated challenges while identifying knowledge gaps in scientific research and data needed for effective management.
Mohammad Azhar Kamal, Hisham N. Altayb, Shima M. Abdulgader, Ehssan Moglad   +3 more
wiley   +1 more source

Serological markers for Leishmania donovani infection in Nepal: agreement between direct agglutination test and rK39 ELISA

, 2010
Visceral leishmaniasis (VL) is an important vector-borne disease caused by Leishmania donovani in the Indian subcontinent. The actual incidence and role of asymptomatic infections in the region are not well known.
Boelaert, M, Menten, J, Khanal, Basudha, Chappuis, Francois, Picado, A, Gidwani, Kamlesh, Veerle Lejon, Lejon, V, Picado, Albert, Joris Menten, Lejon, Veerle, Khanal, B, Menten, Joris, Boelaert, Marleen, Jacquet, Diane, Ostyn, B, Basudha Khanal, Bart Ostyn, Albert Picado, Marleen Boelaert, Chappuis, F, Diane Jacquet, Kamlesh Gidwani, François Chappuis, Rijal, S, Jacquet, D, Rijal, Suman, Ostyn, Bart, Gidwani, K, Suman Rijal   +29 more
core   +1 more source

Induction of apoptosis by zerumbone isolated from Zingiber zerumbet (L.) Smith in protozoan parasite Leishmania donovani due to oxidative stress

Brazilian Journal of Infectious Diseases, 2016
In the present context of emergence of resistance aligned with the conventional anti-leishmanial drugs and occasional treatment failure compelled us to continue the search for replaceable therapeutic leads against Leishmania infection.
Debarati Mukherjee, Chingakham Brajakishor Singh, Somaditya Dey, Supratim Mandal, Joydip Ghosh, Suvadip Mallick, Aabid Hussain, Ningombam Swapana, Samir Anis Ross, Chiranjib Pal   +9 more
doaj   +1 more source

Pyridyl‐Thiazole‐Thiosemicarbazones as Antitrypanosomatidae Agents: Design, Synthesis, and In Silico Profiling

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
A novel pyridine–thiazole derivative, Compound 8, exhibited potent dual antitrypanosomatid activity. It demonstrated remarkable in vitro efficacy against Trypanosoma cruzi (IC50 = 1.0 µM) and L. amazonensis (IC50 = 3.9 µM). Molecular docking studies suggested interactions with heme and multiple molecular targets.
Anderson José Firmino Santos da Silva, Daiane Santiago da Cruz Olimpio, Lucas Manoel da Silva Sousa, Graziella Leite Brondani, Tacylla Lima Silva, Wéllyda Belmira de Lira Silva, Natáli Tereza Capistrano Costa, Marcelo Zaldini Hernandes, Policarpo Ademar Sales Junior, Valéria Rêgo Alves Pereira, Ana Cristina Lima Leite   +10 more
wiley   +1 more source