Results 61 to 70 of about 69,891 (211)

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 10, Page 1686-1701, October 2026.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva, Monique Mantovani, Maria E. S. D. Lino, Aline O. Albuquerque, João H. M. da Silva, Ronaldo A. P. Nagem, Adriana L. Rojas, Geraldo R. Sartori, Eduardo Horjales, David Campbell, Otavio H. Thiemann   +10 more
wiley   +1 more source

Adenine and adenosine salvage in Leishmania donovani [PDF]

Molecular and Biochemical Parasitology, 2013
6-aminopurine metabolism in Leishmania is unique among trypanosomatid pathogens since this genus expresses two distinct routes for adenine salvage: adenine phosphoribosyltransferase (APRT) and adenine deaminase (AAH). To evaluate the relative contributions of APRT and AAH, adenine salvage was evaluated in Δaprt, Δaah, and Δaprt/Δaah null mutants of L ...
Jan M, Boitz, Buddy, Ullman
openaire   +2 more sources

Glutamine supplementation improves the efficacy of miltefosine treatment for visceral leishmaniasis.

PLoS Neglected Tropical Diseases, 2020
BackgroundThe disturbance of host metabolic pathways by Leishmania parasites has crucial consequences for the activation status of immune cells and the outcome of infection.
Carolina Ferreira, Inês Mesquita, Ana Margarida Barbosa, Nuno Sampaio Osório, Egídio Torrado, Charles-Joly Beauparlant, Arnaud Droit, Cristina Cunha, Agostinho Carvalho, Bhaskar Saha, Jerôme Estaquier, Ricardo Silvestre   +11 more
doaj   +1 more source

Coumarin‐Benzimidazole Hybrids as Multitarget Scaffolds for Antileishmanial Drug Discovery

ChemistrySelect, Volume 11, Issue 38, 13 October 2026.
Coumarin‐benzimidazole hybrids emerge as promising antileishmanial agents through virtual screening against essential Leishmania enzymes, Cathepsin B (CatB), and N‐myristoyltransferase (NMT). Molecular docking and dynamics simulations reveal highly stable target interactions that surpass the reference drug miltefosine (MTF).
Fernanda Melo Jucá, Damião Sampaio de Sousa, Caio Henrique Alexandre Roberto, Márcia Machado Marinho, Emmanuel Silva Marinho   +4 more
wiley   +1 more source

Carbon Dioxide Assimilation by Leishmania donovani [PDF]

Nature, 1960
WHILE studying the glucose metabolism of Leishmania donovani, the protozoan organism causing visceral leishmaniasis, it has been found that cell suspensions of this organism in a saline-bicarbonate buffer containing glucose can assimilate, a measurable amount of carbon dioxide along with the formation of different acidic end products1.
A N, CHATTERJEE, J J, GHOSH
openaire   +2 more sources

Comparison of Bloodmeal Digestion and the Peritrophic Matrix in Four Sand Fly Species Differing in Susceptibility to Leishmania donovani. [PDF]

PLoS ONE, 2015
The early stage of Leishmania development in sand flies is closely connected with bloodmeal digestion. Here we compared various parameters of bloodmeal digestion in sand flies that are either susceptible (Phlebotomus argentipes and P.
Katerina Pruzinova, Jovana Sadlova, Veronika Seblova, Miroslav Homola, Jan Votypka, Petr Volf   +5 more
doaj   +1 more source

Synthesis, Anti‐Leishmania amazonensis Activity, Cytotoxicity, and Molecular Docking of Anthranilate–Naphthoquinone Hybrids

ChemistrySelect, Volume 11, Issue 40, 27 October 2026.
New anthranilate–naphthoquinone hybrids display potent inhibition of Leishmania (L.) amazonensis with low host cell toxicity. Molecular docking reveals key interactions with TR, GP63, and PTR1, suggesting a multitarget mechanism that contributes to parasite death.
Eduardo Miranda da Silva Magesfeste, Lidilhone Hamerski, Diego Mendes Nunes, Ana Paula Sotero da Silva Ribeiro, Elvira Maria Saraiva, Magaly Girão Albuquerque, Camilo Henrique da Silva Lima, Bárbara Vasconcellos da Silva   +7 more
wiley   +1 more source

Perillic Acid Synergizes With the Miltefosine Leishmanicidal Effect Against Leishmania amazonensis

Parasite Immunology, Volume 48, Issue 10, October 2026.
ABSTRACT Perillic acid (PA), a monocyclic monoterpene derived from limonene, was evaluated for its leishmanicidal activity alone and in combination with miltefosine, as well as in its microemulsion‐based formulation. PA demonstrated synergistic activity with miltefosine and was effective against both promastigote and amastigote forms of Leishmania ...
C. Ferreira, M. Paschoal, C. L. A. Passos, K. G. H. Silva, K. C. H. Silva, E. M. Saraiva, D. C. Soares   +6 more
wiley   +1 more source

Glycoprotein 63 (gp63) genes show gene conversion and reveal the evolution of Old World Leishmania.

, 2006
Species of the subgenus Leishmania (Leishmania) cause the debilitating disease leishmaniasis on four continents. Species grouped within the Leishmania donovani complex cause visceral leishmaniasis, a life-threatening disease, often associated with ...
Mauricio, Isabel L, Figuerola, Jordi, Soriguer, Ramón C., Miles, Michael A, López, Guillermo, Stothard, J Russell, Gaunt, Michael W   +6 more
core   +1 more source

Domestic animals and epidemiology of visceral leishmaniasis, Nepal. [PDF]

, 2010
On the Indian subcontinent, visceral leishmaniasis (VL) is considered an anthroponosis. To determine possible reasons for its persistence during interepidemic periods, we mapped Leishmania infections among healthy persons and animals in an area of active
Gert Van der Auwera, De Doncker, Simonne, Khanal, Basudha, Speybroeck, Niko, Jean-Claude Dujardin, Bhattarai, N. R., Picado, Albert, Ostyn, B., Dujardin, J. C., Dujardin, Jean-Claude, Niko Speybroeck, Dujardin, Jean Claude, Clive Davies, Davies, C., Van der Auwera, G., Boelaert, M., Dirk Berkvens, Narayan Raj Bhattarai, Boelaert, Marleen, Bhattarai, Narayan Raj, Simonne De Doncker, Das, M. L., Das, Murari Lal, Davies, Clive, Rijal, S., Basudha Khanal, Bart Ostyn, Marc Coosemans, Khanal, B., Picado, A., Coosemans, Marc, Albert Picado, Marleen Boelaert, Berkvens, Dirk, Coosemans, M., Speybroeck, N., Van der Auwera, Gert, Rijal, Suman, De Doncker, S., Berkvens, D., Ostyn, Bart, Murari Lal Das, Suman Rijal   +42 more
core   +1 more source