Results 61 to 70 of about 65,283 (218)

The role of PD-1 in regulation of macrophage apoptosis and its subversion by Leishmania donovani

Clinical & Translational Immunology, 2017
Programmed death‐1 receptor (PD‐1) expressed in many immune cells is known to trigger T‐cell exhaustion but the significance of macrophage‐associated PD‐1 in relevance to macrophage apoptosis is not known.
Shalini Roy, Purnima Gupta, Shreyasi Palit, M. Basu, Anindita Ukil, P. Das   +5 more
semanticscholar   +1 more source

Peptide‐Enabled Nanoplatforms for Malaria and Leishmaniasis: From Intracellular Targeting to Translational Diagnostic Perspectives

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
Peptide‐enabled nanoplatforms offer multifunctional strategies for the treatment and diagnosis of malaria and leishmaniasis. Liposomal, polymeric, and metallic nanocarriers, together with cell‐penetrating peptides and parasite‐derived mimotopes, can improve targeted drug delivery, stability, bioavailability, and intracellular localization.
Christian S. Carnero Canales, Ana Clara Lunardi Yagi, Túlio Custódio Reis, Jessica Ingrid Cazorla, Jade Rojas Villar, Marcia A. Graminha, Roxana Yesenia Pastrana Alta, Fernando Rogério Pavan   +7 more
wiley   +1 more source

Asymptomatic Leishmania donovani infection and associated factors among blood donors attending at Metema district Blood Bank, Northwest Ethiopia: a cross- sectional study

Archives of Public Health, 2023
Background Ethiopia is one of the top 10 countries in the world where 90% visceral leishmaniasis cases are reported. Metema-Humera lowlands are the most important foci in Ethiopia. Blood transfusion in visceral leishmaniasis endemic foci in Ethiopia does
Iyasu Melkie, Mulat Yimer, Getaneh Alemu, Banchamlak Tegegne   +3 more
doaj   +1 more source

Tuberculosis in Sudan: A Comprehensive Narrative Review of Epidemiological Trends, Diagnosis, Drug Resistance, Challenges, and Data Gaps

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims This narrative review aims to provide a comprehensive overview of tuberculosis (TB) in Sudan, focusing on prevalence, drug resistance patterns, and associated challenges while identifying knowledge gaps in scientific research and data needed for effective management.
Mohammad Azhar Kamal, Hisham N. Altayb, Shima M. Abdulgader, Ehssan Moglad   +3 more
wiley   +1 more source

Proteomic analysis of the secretome of Leishmania donovani [PDF]

Genome Biology, 2008
Abstract Background Leishmania and other intracellular pathogens have evolved strategies that support invasion and persistence within host target cells. In some cases the underlying mechanisms involve the export of virulence factors into the host cell cytosol.
Silverman, J M, Chan, Simon K, Robinson, Dale P, Dwyer, Dennis M, Nandan, Devki, Foster, Leonard J, Reiner, Neil E   +6 more
openaire   +3 more sources

Pyridyl‐Thiazole‐Thiosemicarbazones as Antitrypanosomatidae Agents: Design, Synthesis, and In Silico Profiling

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
A novel pyridine–thiazole derivative, Compound 8, exhibited potent dual antitrypanosomatid activity. It demonstrated remarkable in vitro efficacy against Trypanosoma cruzi (IC50 = 1.0 µM) and L. amazonensis (IC50 = 3.9 µM). Molecular docking studies suggested interactions with heme and multiple molecular targets.
Anderson José Firmino Santos da Silva, Daiane Santiago da Cruz Olimpio, Lucas Manoel da Silva Sousa, Graziella Leite Brondani, Tacylla Lima Silva, Wéllyda Belmira de Lira Silva, Natáli Tereza Capistrano Costa, Marcelo Zaldini Hernandes, Policarpo Ademar Sales Junior, Valéria Rêgo Alves Pereira, Ana Cristina Lima Leite   +10 more
wiley   +1 more source

Antimicrobial Activity of Locally Synthesized Carbon Nanosphere on Some Pathogenic Species of Bacteria and Parasites

مجلة بغداد للعلوم, 2021
Antibacterial activity of CNSs against Staphylococcus aureus and Escherichia coli was estimated. Higher inhibition zone of 18 mm and 20 mm were observed against S.
Ali Taha , Abdulqader Faisal, Shaimaa A., Mohammad Al-Halbosiy   +3 more
doaj   +1 more source

Leishmania donovani resides in modified early endosomes by upregulating Rab5a expression via the downregulation of miR-494

PLoS Pathogens, 2017
Several intracellular pathogens arrest the phagosome maturation in the host cells to avoid transport to lysosomes. In contrast, the Leishmania containing parasitophorous vacuole (PV) is shown to recruit lysosomal markers and thus Leishmania is postulated
Jitender Verma, R. Rastogi, A. Mukhopadhyay   +2 more
semanticscholar   +1 more source

HetCA/STOCSY‐Guided Dereplication of Artemisia arborescens Reveals Furofuran Lignans with Antileishmanial Effects

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Bioactive metabolites can remain hidden in negligible activity extracts. A statistical spectroscopy–driven dereplication workflow integrating the HeteroCovariance Approach (HetCA) and Statistical Total Correlation Spectroscopy (STOCSY) prioritized furofuran lignans in Artemisia arborescens, identifying three compounds with moderate antileishmanial ...
Olga Karoutzou, Stavros Beteinakis, Olga Koutsoni, Despina Smirlis, Maria Halabalaki, Leandros Alexios Skaltsounis, Emmanuel Mikros   +6 more
wiley   +1 more source

Genomic and transcriptomic alterations in Leishmania donovani lines experimentally resistant to antileishmanial drugs

International Journal for Parasitology: Drugs and Drug Resistance, 2018
Leishmaniasis is a serious medical issue in many countries around the World, but it remains largely neglected in terms of research investment for developing new control and treatment measures.
A. Rastrojo, Raquel Garcia-Hernandez, Paola Vargas, Esther Camacho, L. Corvo, H. Imamura, J. Dujardin, S. Castanys, Begoña Aguado, F. Gamarro, J. Requena   +10 more
semanticscholar   +1 more source