Results 91 to 100 of about 65,283 (218)

Arginase Is Essential for Survival of Leishmania donovani Promastigotes but Not Intracellular Amastigotes

Infection and Immunity, 2016
Studies of Leishmania donovani have shown that both ornithine decarboxylase and spermidine synthase, two enzymes of the polyamine biosynthetic pathway, are critical for promastigote proliferation and required for maximum infection in mice.
Jan M. Boitz, C. Gilroy, Tamara Olenyik, D. Paradis, Jasmine Perdeh, Kristie Dearman, M. Davis, Phillip A. Yates, Yue-Xin Li, M. Riscoe, B. Ullman, Sigrid C. Roberts   +11 more
semanticscholar   +1 more source

Thymus and Leishmania at the Crossroads: Autoimmunity and Cancer

Immunology, Volume 178, Issue 3, Page 377-386, July 2026.
Conceptual ‘Crossroads Model’ linking Leishmania, thymic infection and immune dysregulation: an integrative model is proposed in which Leishmania infection disrupts thymic architecture and stromal–thymocyte interactions. These alterations converge to promote defective tolerance, increased autoimmune risk and a microenvironment permissive to malignant ...
Alef Batista Bezerra Barros, Gabriel Augusto Leite, Arthur Gomes de Andrade, Maria Danielma dos Santos Reis, Luiz Henrique Agra Cavalcante‐Silva, Marvin Paulo Lins   +5 more
wiley   +1 more source

Hemophagocytosis in Experimental Visceral Leishmaniasis by Leishmania donovani

PLoS Neglected Tropical Diseases, 2016
Hemophagocytosis is a phenomenon in which macrophages phagocytose blood cells. There are reports on up-regulated hemophagocytosis in patients with infectious diseases including typhoid fever, tuberculosis, influenza and visceral leishmaniasis (VL ...
Ayako Morimoto, Satoko Omachi, Y. Osada, J. Chambers, K. Uchida, C. Sanjoba, Y. Matsumoto, Y. Goto   +7 more
semanticscholar   +1 more source

Identification of Distinct Interacting Proteins of Giardia lamblia Centrins Using Yeast Two‐Hybrid Assays

Journal of Eukaryotic Microbiology, Volume 73, Issue 4, July/August 2026.
ABSTRACT Giardia lamblia, a protozoan parasite that causes diarrhea in humans, contains two centrins implicated in cellular morphology and cell division. To identify proteins interacting with each G. lamblia centrin (GlCent), we performed a yeast two‐hybrid assay.
Mee Young Shin, Juri Kim, Soon‐Jung Park   +2 more
wiley   +1 more source

First Molecular Characterization of Leishmania Species Causing Visceral Leishmaniasis among Children in Yemen.

PLoS ONE, 2016
Visceral leishmaniasis (VL) is a debilitating, often fatal disease caused by Leishmania donovani complex; however, it is a neglected tropical disease. L. donovani complex comprises two closely related species, L. donovani that is mostly anthroponotic and
Mohammed A K Mahdy, Abdulsalam M Al-Mekhlafi, Rashad Abdul-Ghani, Reyadh Saif-Ali, Hesham M Al-Mekhlafi, Samira M Al-Eryani, Yvonne A L Lim, Rohela Mahmud   +7 more
doaj   +1 more source

Glutathione and the redox control system trypanothione/trypanothione reductase are involved in the protection of Leishmania spp. against nitrosothiol-induced cytotoxicity

Brazilian Journal of Medical and Biological Research, 2006
Glutathione is the major intracellular antioxidant thiol protecting mammalian cells against oxidative stress induced by oxygen- and nitrogen-derived reactive species.
P.R.T. Romão, J. Tovar, S.G. Fonseca, R.H. Moraes, A.K. Cruz, J.S. Hothersall, A.A. Noronha-Dutra, S.H. Ferreira, F.Q. Cunha   +8 more
doaj   +1 more source

Pancytopenia With Hypocellular Bone Marrow Revealing Extrahepatic Portal Venous Obstruction and Cavernous Transformation in a Child: A Case Report of a Diagnostic Challenge

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Extrahepatic portal venous obstruction (EHPVO) is a leading cause of prehepatic portal hypertension in children, particularly in developing countries. While upper gastrointestinal bleeding is the most common presentation, EHPVO may rarely manifest predominantly with hematological abnormalities due to hypersplenism, posing a diagnostic ...
Swekchha Adhikari, Aakash Pandit, Melisha Koirala, Biplav Lamichhane, Ram Khadka, Aashish Panta, Shuvra Rimal   +6 more
wiley   +1 more source

Identification of Leishmania donovani Topoisomerase 1 inhibitors via intuitive scaffold hopping and bioisosteric modification of known Top 1 inhibitors

Scientific Reports, 2016
A library of arylidenefuropyridinediones was discovered as potent inhibitors of Leishmania donovani Topoisomerase 1 (LdTop1) where the active molecules displayed considerable inhibition with single digit micromolar EC50 values. This molecular library was
Rajinikanth Mamidala, Papiya Majumdar, K. Jha, Chandramohan Bathula, Rahul Agarwal, M. Chary, H. K. Mazumdar, P. Munshi, Subhabrata Sen   +8 more
semanticscholar   +1 more source

Can cutaneous leishmaniasis provoke a resurgence of kala-azar in the Indian subcontinent?

BMC Infectious Diseases
Background The ongoing kala-azar elimination program in Nepal is based on the assumption of anthroponotic transmission of the protozoan parasite Leishmania donovani. This parasite species was recently also found in lesions of cutaneous leishmaniasis (CL)
Narayan Raj Bhattarai, Keshav Rai, Surendra Uranw, Dhan Keshar Khadka, Basudha Khanal, Gokarna Dahal, Sushmita Pradhan, Sushil Dhakal, Pieter Monsieurs, Tanyth de Gooyer, Kristien Cloots, Epco Hasker, Gert Van der Auwera   +12 more
doaj   +1 more source

Current Perspectives on Leishmaniasis

Journal of Gandaki Medical College, 2019
No abstract available.
KR Reddy
doaj   +1 more source