Results 101 to 110 of about 65,283 (218)

Glycobiology of Leishmania donovani.

The Indian journal of medical research, 2006
Leishmania donovani, the causative organism of visceral leishmaniasis (VL) is one of the deadliest of the entire known Leishmania species. This protozoan parasite displays immense adaptability to survive under extremely harsh conditions. Cell surface glycoconjugates play a pivotal role in parasite virulence and infectivity.
Sumi, Mukhopadhyay, Chitra, Mandal
openaire   +1 more source

Leptomonas seymouri: Adaptations to the Dixenous Life Cycle Analyzed by Genome Sequencing, Transcriptome Profiling and Co-infection with Leishmania donovani

PLoS Pathogens, 2015
The co-infection cases involving dixenous Leishmania spp. (mostly of the L. donovani complex) and presumably monoxenous trypanosomatids in immunocompromised mammalian hosts including humans are well documented.
N. Kraeva, A. Butenko, J. Hlaváčová, A. Kostygov, J. Myšková, Danyil Grybchuk, T. Lestinova, J. Votýpka, P. Volf, F. Opperdoes, P. Flegontov, J. Lukeš, V. Yurchenko   +12 more
semanticscholar   +1 more source

Global Analysis of Protein N-Myristoylation and Exploration of N-Myristoyltransferase as a Drug Target in the Neglected Human Pathogen Leishmania donovani

Chemistry and Biology, 2015
Summary N-Myristoyltransferase (NMT) modulates protein function through the attachment of the lipid myristate to the N terminus of target proteins, and is a promising drug target in eukaryotic parasites such as Leishmania donovani. Only a small number of
M. Wright, Daniel Paape, Elisabeth M. Storck, R. Serwa, Deborah F. Smith, E. Tate   +5 more
semanticscholar   +1 more source

Leishmania donovani donovani and Leishmania donovani chagasi as antigens in a direct agglutination assay for the diagnosis of kala-azar.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, 1990
The need for a reliable method for the immunological diagnosis of kala-azar is imperative. Leishmania donovani donovani and L. donovani chagasi culture promastigotes were compared as antigens in a direct agglutination test (DAT) for the diagnosis of visceral leishmaniasis in Brazil.
C R, Andrade, A E, Nascimento, P M, Moura, P P, Andrade   +3 more
openaire   +1 more source

Fitness of Leishmania donovani Parasites Resistant to Drug Combinations

PLoS Neglected Tropical Diseases, 2015
Drug resistance represents one of the main problems for the use of chemotherapy to treat leishmaniasis. Additionally, it could provide some advantages to Leishmania parasites, such as a higher capacity to survive in stress conditions.
Raquel Garcia-Hernandez, V. Gómez-Pérez, S. Castanys, F. Gamarro   +3 more
semanticscholar   +1 more source

Comparative study of the biological behaviour in hamster of two isolates of leishmania characterized respectively as L. major-like and L. donovani

Revista do Instituto de Medicina Tropical de São Paulo, 1988
Hamster inoculated intraperitoneally with 1 x 10(7) parasites of L. donovani and L. major-like of the New World were studied in groups of 15, 30, 60 and 90 days of infection. The parasite load and density showed progressive increase with the evolution of
M. I. S. Duarte, M. D. Laurenti, H. F. Andrade Jr., C. E. P. Corbett   +3 more
doaj   +1 more source

Proteomic-Based Approach To Gain Insight into Reprogramming of THP-1 Cells Exposed to Leishmania donovani over an Early Temporal Window

Infection and Immunity, 2015
Leishmania donovani, a protozoan parasite, is the causative agent of visceral leishmaniasis. It lives and multiplies within the harsh environment of macrophages.
Ashutosh Kumar Singh, R. Pandey, J. Siqueira-Neto, Yong-Jun Kwon, L. Freitas-Junior, C. Shaha, R. Madhubala   +6 more
semanticscholar   +1 more source

Effective Tetradentate Compound Complexes against Leishmania spp. that Act on Critical Enzymatic Pathways of These Parasites

Molecules, 2018
The spectrum and efficacy of available antileishmanial drugs is limited. In the present work we evaluated in vitro the antiproliferative activity of 11 compounds based on tetradentate polyamines compounds against three Leishmania species (L. braziliensis,
Kristína Urbanová, Inmaculada Ramírez-Macías, Rubén Martín-Escolano, María José Rosales, Olaf Cussó, Joan Serrano, Anna Company, Manuel Sánchez-Moreno, Miquel Costas, Xavi Ribas, Clotilde Marín   +10 more
doaj   +1 more source

Detection of Leishmania donovani and L. tropica in Ethiopian wild rodents.

Acta Tropica, 2015
Human visceral (VL, also known as Kala-azar) and cutaneous (CL) leishmaniasis are important infectious diseases affecting countries in East Africa that remain endemic in several regions of Ethiopia.
Aysheshm Kassahun, J. Sádlová, Vit Dvorak, T. Košťálová, I. Rohousova, D. Frynta, T. Aghová, D. Yasur-Landau, Wessenseged Lemma, A. Hailu, G. Baneth, A. Warburg, P. Volf, J. Votýpka   +13 more
semanticscholar   +1 more source

LEISHMANIA DONOVANI AND LEISHMANIA TROPICA [PDF]

BMJ, 1912
openaire   +2 more sources