Results 61 to 70 of about 11,452 (171)

Dicentrine, an Aporphine Alkaloid From Ocotea langsdorffii, Induces Mitochondrial Dysfunction and Oxidative Stress in Leishmania (L.) infantum

Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.
Dicentrine, an aporphine alkaloid, exhibits potent in vitro antileishmanial activity against Leishmania species with high selectivity and low macrophage cytotoxicity. Mechanistic studies reveal that the compound triggers parasite death possibly by inducing mitochondrial membrane disruption and oxidative stress.
Camila S. de Freitas, Eduardo Oliveira S. da Silva, Daniela C. Tristão, Guilherme M. Antar, Daniela P. Lage, Dóris M. Abrão, Luciana M. Ribeiro Antinarelli, Elaine S. Coimbra, João Henrique G. Lago, Eduardo A. F. Coelho   +9 more
wiley   +1 more source

Leishmania major: differential regulation of the surface metalloprotease in amastigote and promastigote stages.

, 1992
During its life cycle, the protozoan parasite Leishmania major alternates from an intracellular amastigote form in the mammalian host to a flagellated promastigote form in the insect vector.
Bouvier, J., Louis, J., Rosat, J.P., Bordier, C., Schneider, P.   +4 more
core   +1 more source

Murine T Cell‐Dependent Response Affects Leishmania amazonensis Amastigote Survival and Virulence

Cell Biology International, Volume 50, Issue 8, August 2026.
ABSTRACT Our group has previously described the infection course of Leishmania amazonensis in BALB/c and BALB/cnu/nu mice, which have distinct T‐cell dependent responses. In this study, lesion‐derived amastigotes exhibited differential protein expression in a host‐dependent manner.
Gustavo Henrique Corrêa Soares, Gustavo Rolim Barbosa, Beatriz Simonsen Stolf   +2 more
wiley   +1 more source

Study on the Occurrence of Genetic Exchange Among Parasites of the Leishmania mexicana Complex

Frontiers in Cellular and Infection Microbiology, 2020
In Leishmania, genetic exchange has been experimentally demonstrated to occur in the sand fly vector and in promastigote axenic cultures through a meiotic-like process.
Roman Telittchenko, Albert Descoteaux
doaj   +1 more source

Stage-specific pathways of Leishmania infantum chagasi entry and phagosome maturation in macrophages. [PDF]

PLoS ONE, 2011
The life stages of Leishmania spp. include the infectious promastigote and the replicative intracellular amastigote. Each stage is phagocytosed by macrophages during the parasite life cycle.
Nilda E Rodríguez, Upasna Gaur Dixit, Lee-Ann H Allen, Mary E Wilson   +3 more
doaj   +1 more source

Exploring Biological Properties of Manganese(II)‐Phenanthroline‐Based Complexes: In Vitro Insights

ChemistrySelect, Volume 11, Issue 29, 3 August 2026.
Four Mn(II) complexes with phenanthroline derivatives were studied. These compounds were tested against several parasites and different human cancer cells. Despite its cytotoxicity on breast cancer, DNA seems not to be the main biological target. These complexes can drive the design and development of new metal‐based agents with improved biological ...
Roberto S. Silva, Marcos V. Palmeira‐Mello, Mikaelly P. Caet, Celisnolia M. Leite, Arieli B. Portugal, Pedro H. Machado, Alexandre B. Carvalho, Isabel Correia, Leonardo M. Moreira, Thatiana L. B. V. Simão, Elena Lasunskaia, Michelle F. Muzitano, José L. Nepomuceno‐Silva, João L. M. Wanderley, Javier Ellena, Alzir A. Batista, Mario S. Schultz   +16 more
wiley   +1 more source

Leishmania donovani development in Phlebotomus argentipes: comparison of promastigote- and amastigote-initiated infections. [PDF]

, 2016
Leishmania parasites alternate in their life cycle between promastigote stages that develop in the gut of phlebotomine sand flies and amastigotes residing inside phagocytic cells of vertebrate hosts.
Yeo, Matthew, Sadlova, Jovana, Volf, Petr, Votypka, Jan, Myskova, Jitka, Lestinova, Tereza   +5 more
core   +1 more source

Butanol Fraction of Kelussia odoratissima Mozaff Inhibits the Growth of Leishmania major Promastigote and Amastigote [PDF]

, 2020
Naturally derived compounds have been used to treat several infectious diseases including leishmaniasis. The study aimed to investigate the in vitro effects of Kelussia odoratissima Mozaff extract on Leishmania major promastigote and amastigote.
Norouzi, R., de Lourdes Pereira, M., Nissapatorn, V., Nilforoushzadeh, M., Hejazi, S. H., Siyadatpanah, A., Mirzaei, F., Maleksabet, A., Hosseini, M., Mitsuwan, W.   +9 more
core   +1 more source

Antileishmanial activity of polycyclic derivatives

Parasite, 2005
33 polycyclic derivatives have been studied and tested on Leishmania donovani and L. major promastigotes. Their antileishmanial activity was assessed in vitro and an assay of their cytotoxicity was realized on human myelomonocytic cell line.
Sarciron M.E., Terreux R., Prieto Y., Cortes M., Cuellar M.A., Tapia R.A., Domard M., Walchshofer N., Pétavy A.F.   +8 more
doaj   +1 more source

Identification of a Benzenesulfonylpiperazine Derivative With In Vivo Efficacy Against Visceral Leishmaniasis

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
This work highlights the satisfactory pharmacokinetic profile of two benzenesulfonylpiperazine lead candidates, followed by in vivo assessment in a murine model of visceral leishmaniasis. This assessment identified compound 2 as moderately active at a lower dose, but its efficacy increased at higher doses, though with concerns regarding safety.
Thibault Joseph William Jacques Dit Lapierre, Mariza Gabriela Faleiro de Moura Lodi Cruz, Guilherme Freitas de Lima Hercos, Rafael Consolin Chelucci, Simone Michelan‐Duarte, Gisele Barbosa, Analu R. Costa, Miguel Angel Chávez‐Fumagalli, Paula Derksen Macruz, Eduardo Jorge Pilau, Leonardo L. G. Ferreira, Adriano D. Andricopulo, Silvane Maria Fonseca Murta, Celso de Oliveira Rezende Júnior   +13 more
wiley   +1 more source