Results 81 to 90 of about 11,689 (228)

Dicentrine, an Aporphine Alkaloid From Ocotea langsdorffii, Induces Mitochondrial Dysfunction and Oxidative Stress in Leishmania (L.) infantum

Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.
Dicentrine, an aporphine alkaloid, exhibits potent in vitro antileishmanial activity against Leishmania species with high selectivity and low macrophage cytotoxicity. Mechanistic studies reveal that the compound triggers parasite death possibly by inducing mitochondrial membrane disruption and oxidative stress.
Camila S. de Freitas, Eduardo Oliveira S. da Silva, Daniela C. Tristão, Guilherme M. Antar, Daniela P. Lage, Dóris M. Abrão, Luciana M. Ribeiro Antinarelli, Elaine S. Coimbra, João Henrique G. Lago, Eduardo A. F. Coelho   +9 more
wiley   +1 more source

Average allopurinol IC50 values of promastigote and axenic amastigotes.

, 2016
Average allopurinol IC50 values found for promastigotes and axenic amastigotes of isolates from dogs in the study groups. Numbers in labels represent group mean ± STDEV.
Daniel Yasur-Landau (843674), Lior David (22328), Gad Baneth (254948), Charles L. Jaffe (254946)   +3 more
core   +1 more source

Murine T Cell‐Dependent Response Affects Leishmania amazonensis Amastigote Survival and Virulence

Cell Biology International, Volume 50, Issue 8, August 2026.
ABSTRACT Our group has previously described the infection course of Leishmania amazonensis in BALB/c and BALB/cnu/nu mice, which have distinct T‐cell dependent responses. In this study, lesion‐derived amastigotes exhibited differential protein expression in a host‐dependent manner.
Gustavo Henrique Corrêa Soares, Gustavo Rolim Barbosa, Beatriz Simonsen Stolf   +2 more
wiley   +1 more source

ROC plot comparing the performance of the rK39 strip test to serologic techniques utilizing promastigote antigens for diagnosis of Visceral Leishmaniasis.

, 2013
ROC plot comparing the performance of the rK39 strip test to serologic techniques utilizing promastigote antigens for diagnosis of Visceral Leishmaniasis.
Sóstenes Mistro (333974), Zuinara Maia (333972), Sanjay R. Mehta (333976), Roberto Badaro (333977), Carlos Maurício Cardeal Mendes (333975), Monique Lírio (333973)   +5 more
core   +1 more source

Number of hits identified with the intracellular amastigote and the promastigote primary screens.

, 2013
White bar: number of compounds identified in both screens. Light grey and black bars: number of compounds specifically active against promastigotes and intracellular amastigotes respectively.
James H. McKerrow (113918), Kenny K. H. Ang (145735), Geraldine De Muylder (132472), Michelle R. Arkin (114394), Juan C. Engel (145730), Steven Chen (145741)   +5 more
core   +1 more source

Population Changes in Leishmania chagasi Promastigote Developmental Stages Due to Serial Passage [PDF]

, 2010
Leishmania chagasi causes visceral leishmaniasis, a potentially fatal disease of humans. Within the sand fly vector, L. chagasi replicates as promastigotes which undergo complex changes in morphology as they progress from early stage procyclic ...
Nathan M. Romine, Romine, Nathan, Beetham, Jeffrey, Jeffrey K. Beetham, Lei, Soi Meng, Soi Meng Lei   +5 more
core   +1 more source

In Vitro Antiparasitic and Apoptotic Effects of Antimony Sulfide Nanoparticles on Leishmania infantum

Journal of Parasitology Research, 2012
Visceral leishmaniasis is one of the most important sever diseases in tropical and subtropical countries. In the present study the effects of antimony sulfide nanoparticles on Leishmania infantum in vitro were evaluated.
Saied Soflaei, Abdolhossein Dalimi, Fatemeh Ghaffarifar, Mojtaba Shakibaie, Ahmad Reza Shahverdi, Mohsen Shafiepour   +5 more
doaj   +1 more source

An insight into the constitutive proteome throughout Leishmania donovani promastigote growth and differentiation

, 2019
12 p.-5 fig.-1 tab.Anthroponotic visceral leishmaniasis is a life-threatening disease caused by Leishmania donovani (Kinetoplastida: Trypanosomatidae) in East Africa and the Indian subcontinent.
Ciordia, Sergio, García-Tabares, Francisco, Larraga, Vicente, Alonso, Ana, Mena, M. Carmen, Alcolea, Pedro J.   +5 more
core   +1 more source

Leishmania (Viannia) lainsoni: occurrence of intracellular promastigote forms in vivo and in vitro [PDF]

, 2006
Experimental chronic (45-day-old) skin lesion in hamster hind foot induced by Leishmania (Viannia) lainsoni infection showed the presence of promastigote forms in the tissue, inside parasitophorous vacuoles, as assessed by transmission electron ...
José R Corrêa, Soares, Maurilio J., Maurilio J Soares, Corrêa, José R.   +3 more
core   +1 more source