Results 1 to 10 of about 12,502 (214)

De Novo Synthesis of Phosphatidylcholine Is Essential for the Promastigote But Not Amastigote Stage in Leishmania major

Frontiers in Cellular and Infection Microbiology, 2021
Phosphatidylcholine (PC) is the most abundant type of phospholipids in eukaryotes constituting ~30% of total lipids in Leishmania. PC synthesis mainly occurs via the choline branch of the Kennedy pathway (choline ⇒ choline-phosphate ⇒ CDP-choline ⇒ PC ...
Fong-Fu Hsu, Kai Zhang, Mattie Christine Pawlowic   +2 more
exaly   +3 more sources

Cutaneous leishmaniasis [PDF]

Opšta Medicina, 2022
Introduction. The most common form of leishmaniasis is cutaneous leishmaniasis. It presents with cutaneous lesions of the unprotected parts of the skin which leave scars later on. The causative agents are protozoae from the Leishmania species , and there
Dacić Slavica D., Ivanović Dragana M., Pavlović Ljiljana S.   +2 more
doaj   +1 more source

The Characterization and Antileishmanial Evaluation on Leishmania Major with Chitosan/Zno Bio-Nanocomposite as Drug Delivery Systems [PDF]

Nanomedicine Research Journal, 2022
Background: Leishmaniasis is a global disease that poses a threat to human life and is associated with complications. Current medications have limitations due to serious side effects, costs and drug resistance.
Mohsen Mahmoudi, Mohammad Shabani, Seyed Ahmad Dehdast, Sedigheh Saberi, Taher Elmi, Ghazaleh Chiari Fard, Fatemeh Tabatabaie, Sakineh Akbari   +7 more
doaj   +1 more source

Proximity-Dependent Biotinylation and Identification of Flagellar Proteins in Trypanosoma cruzi

mSphere, 2023
The flagellated kinetoplastid protozoan and causative agent of human Chagas disease, Trypanosoma cruzi, inhabits both invertebrate and mammalian hosts over the course of its complex life cycle. In these disparate environments, T.
Madalyn M. Won, Aaron Baublis, Barbara A. Burleigh   +2 more
doaj   +1 more source

Antiparasitic and cytotoxicity effects of 7-hydroxy-4′- methoxy isoflavone against Leishmania major [PDF]

Journal of HerbMed Pharmacology, 2023
Introduction: Leishmaniasis caused by Leishmania spp. is observed in most parts of the world. Although, glucantime, a pentavalent antimony compound, and other synthetic drugs are broadly applied for leishmaniasis therapy; however, the use of these ...
Mahdi Aghaei, Farhood Alizadegan, Yosra Raziani, Githa Kishore, Massumeh Saadatmand, Suja Ajoy Kumar   +5 more
doaj   +1 more source

A patient with leishmaniasis presenting with longstanding pancytopenia and hepatosplenomegaly

Clinical Case Reports, 2023
Leishmaniasis is a common cause of pancytopenia and hepatosplenomegaly in tropical and subtropical regions. A high index of suspicion is required to diagnose and manage patients with leishmaniasis.
Simon Onsongo, Evelyne Mulwa, Bonface Mutiso   +2 more
doaj   +1 more source

Leishmania amazonensis Subverts the Transcription Factor Landscape in Dendritic Cells to Avoid Inflammasome Activation and Stall Maturation

Frontiers in Immunology, 2020
Leishmania parasites are the causative agents of human leishmaniases. They infect professional phagocytes of their mammalian hosts, including dendritic cells (DCs) that are essential for the initiation of adaptive immune responses. These immune functions
Hervé Lecoeur, Hervé Lecoeur, Hervé Lecoeur, Thibault Rosazza, Thibault Rosazza, Kossiwa Kokou, Kossiwa Kokou, Kossiwa Kokou, Hugo Varet, Jean-Yves Coppée, Arezou Lari, Pierre-Henri Commère, Robert Weil, Guangxun Meng, Guangxun Meng, Genevieve Milon, Gerald F. Späth, Gerald F. Späth, Eric Prina, Eric Prina   +19 more
doaj   +1 more source

A rare case of cutaneous leishmaniasis in Kathmandu presenting with features of bacterial skin infection: A case report

Clinical Case Reports, 2023
Leishmaniasis is an infectious disease caused by different species of genus Leishmania and transmitted by sandflies. Lesions of CL are most commonly present in the exposed areas, and the most familiar morphological type is papulo‐nodular.
Anil Regmi, Biplov Adhikari, Pragya Karki, Suwash Baral, Irusha Rani Adhikari   +4 more
doaj   +1 more source

Therapeutic Potential of Green Synthesized Copper Nanoparticles Alone or Combined with Meglumine Antimoniate (Glucantime^®) in Cutaneous Leishmaniasis

Nanomaterials, 2021
Background: In recent years, the focus on nanotechnological methods in medicine, especially in the treatment of microbial infections, has increased rapidly.
Aishah E. Albalawi, Sobhy Abdel-Shafy, Amal Khudair Khalaf, Abdullah D. Alanazi, Parastoo Baharvand, Katrin Ebrahimi, Hossein Mahmoudvand   +6 more
doaj   +1 more source

Detection of Leishmania infantum amastigotes in neutrophil from peripheral blood in a naturally infected dog

Revista Brasileira de Parasitologia Veterinária, 2021
Canine visceral leishmaniasis (CVL) is a zoonotic disease of high lethality caused by Leishmania infantum in the Americas. In the infected dog, the amastigotes are scarce in blood, especially in the late phase of the disease. This study aimed to report a
Gilsan Aparecida de Oliveira, Vitória Aline Santos Sarmento, Ericka Wanessa da Silva Costa, Rômulo Pessoa-e-Silva, Rayana Carla Silva de Morais, Roberto Rômulo Ferreira, Ana Paula Sampaio Feitosa, Fábio André Brayner, Luiz Carlos Alves   +8 more
doaj   +1 more source