Results 31 to 40 of about 8,500 (184)
Dependency relationships between IFT-dependent flagellum elongation and cell morphogenesis in Leishmania [PDF]
Open Biology, 2018 Flagella have multiple functions that are associated with different axonemal structures. Motile flagella typically have a 9 + 2 arrangement of microtubules, whereas sensory flagella normally have a 9 + 0 arrangement.
Jack Daniel Sunter +2 more
doaj +1 more source
Two approaches to discovering and developing new drugs for Chagas disease
Memorias do Instituto Oswaldo Cruz, 2009 This review will focus on two general approaches carried out at the Sandler Center, University of California, San Francisco, to address the challenge of developing new drugs for the treatment of Chagas disease.
JH McKerrow +10 more
doaj +1 more source
Memorias do Instituto Oswaldo Cruz, 2010 Kinetoplastid membrane protein-11 (KMP-11), a protein present in all kinetoplastid protozoa, is considered a potential candidate for a leishmaniasis vaccine.
Denise CS Matos +8 more
doaj +1 more source
Features of host cell invasion by different infective forms of Trypanosoma cruzi [PDF]
Memorias do Instituto Oswaldo Cruz, 1999 Through its life cycle from the insect vector to mammalian hosts Trypanosoma cruzi has developed clever strategies to reach the intracellular milieu where it grows sheltered from the hosts' immune system.
Renato A Mortara +6 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2022 Leishmania is the unicellular parasite transmitted by phlebotomine sand fly bite. It exists in two different forms; extracellular promastigotes, occurring in the gut of sand flies, and intracellular, round-shaped amastigotes residing mainly in vertebrate
Lenka Pacakova +4 more
doaj +1 more source
Journal of the Science of Food and Agriculture, EarlyView.Abstract Since the early 1960s, nanotechnology has been a critical area of science, allowing for the development of sophisticated nanomaterials. Nanofibers, one of the most widely used nanotechnological drug delivery systems, have emerged as a highly versatile platform within modern pharmaceutical sciences.
Heybet Kerem Polat +7 more
wiley +1 more source
Common pathways and outliers in glucose catabolism across Trypanosomatidae
The FEBS Journal, EarlyView.Trypanosomatid parasites, including Trypanosoma sp., Leishmania sp., Phytomonas sp., and Vickermania sp., share a common motif: a metabolism built around the glycosome, a unique peroxisome‐derived organelle housing the first steps of glycolysis. Yet, these organisms have evolved remarkably diverse strategies to catabolize glucose, excreting distinct ...
Fred R. Opperdoes +5 more
wiley +1 more source
Iranian Journal of Parasitology, 2021 Background: Due to numerous side effects of common drugs in treatment of leishmaniasis, new therapeutic approaches focus on herbal compounds. Therefore, we aimed to determine the effect of crocin and stigmasterol on in-vitro growth of promastigotes and ...
Reza RANJBAR +2 more
doaj
ChemMedChem, Volume 21, Issue 19, 14 October 2026.Hit‐to‐lead optimization of morpholinephenylbenzamides reveals key structure–activity relationships against Trypanosoma cruzi and Leishmania infantum. Potency, selectivity, and ADME properties are differentially improved across the series, identifying compounds 20, 24, and 16 as complementary templates for the future design of dual antiparasitic leads.
Danilo Nascimento Farago +15 more
wiley +1 more source
Biotechnology and Applied Biochemistry, Volume 73, Issue 5, Page 2457-2481, October 2026.ABSTRACT Effective vaccines against Trypanosoma cruzi, the causative agent of Chagas disease, are urgently needed. Here, we report the design and in silico validation of a novel multiepitope vaccine construct targeting the key surface proteins ASP‐2 and gp82. Using a comprehensive immunoinformatics pipeline, we identified and selected 38 potent T‐cell (
Maria Karolaynne da Silva +8 more
wiley +1 more source