Results 31 to 40 of about 12,502 (214)
WHO Amastigote Density Scale in Microscopy Positive Specimens.
, 2023 WHO Amastigote Density Scale in Microscopy Positive Specimens.
Maxy B. De los Santos (12602477) +10 more
core +1 more source
mBio, 2018 The mammalian stages of the parasite Trypanosoma cruzi, the causative agent of Chagas disease, exhibit a wide host species range and extensive within-host tissue distribution.
Peter C. Dumoulin, Barbara A. Burleigh
doaj +1 more source
Microorganisms, 2021 This experimental investigation was designed to assess the in vitro and in vivo antileishmanial effects of Z. spina-christi methanolic extract (ZSCME) and also aims to assess some of the antileishmanial mechanisms such as the NO production, apoptosis ...
Aishah E. Albalawi
doaj +1 more source
Türkiye Parazitoloji Dergisi, 2021 Objective:Because the protocols used in the treatment of leishmaniasis can be toxic and have many limitations, such as the development of resistance against such protocols, new treatment options are needed, especially against resistant patients.
Orçun Zorbozan +5 more
doaj +1 more source
A role for extracellular amastigotes in the immunopathology of Chagas disease [PDF]
Memórias do Instituto Oswaldo Cruz, 1999 In spite of the growing knowledge obtained about immune control of Trypanosoma cruzi infection, the mechanisms responsible for the variable clinico-pathological expression of Chagas disease remain unknown. In a twist from previous concepts, recent studies indicated that tissue parasitism is a pre-requisite for the development of chronic myocarditis ...
Julio Scharfstein, Alexandre Morrot
openaire +4 more sources
New diarylsulfonamide inhibitors of Leishmania infantum amastigotes
International Journal for Parasitology: Drugs and Drug Resistance, 2021 New drugs against visceral leishmaniasis with mechanisms of action differing from existing treatments and with adequate cost, stability, and properties are urgently needed. No antitubulin drug is currently in the clinic against Leishmania infantum, the causative agent of visceral leishmaniasis in the Mediterranean area. We have designed and synthesized
Myriam González +5 more
openaire +5 more sources
Molecules, 2018 The spectrum and efficacy of available antileishmanial drugs is limited. In the present work we evaluated in vitro the antiproliferative activity of 11 compounds based on tetradentate polyamines compounds against three Leishmania species (L. braziliensis,
Kristína Urbanová +10 more
doaj +1 more source
Dependency relationships between IFT-dependent flagellum elongation and cell morphogenesis in Leishmania [PDF]
Open Biology, 2018 Flagella have multiple functions that are associated with different axonemal structures. Motile flagella typically have a 9 + 2 arrangement of microtubules, whereas sensory flagella normally have a 9 + 0 arrangement.
Jack Daniel Sunter +2 more
doaj +1 more source
Two approaches to discovering and developing new drugs for Chagas disease
Memorias do Instituto Oswaldo Cruz, 2009 This review will focus on two general approaches carried out at the Sandler Center, University of California, San Francisco, to address the challenge of developing new drugs for the treatment of Chagas disease.
JH McKerrow +10 more
doaj +1 more source
Memorias do Instituto Oswaldo Cruz, 2010 Kinetoplastid membrane protein-11 (KMP-11), a protein present in all kinetoplastid protozoa, is considered a potential candidate for a leishmaniasis vaccine.
Denise CS Matos +8 more
doaj +1 more source