Results 51 to 60 of about 8,500 (184)

Elimination of Leishmania donovani amastigotes by activated macrophages [PDF]

Infection and Immunity, 1981
Tissue macrophages are the obligatory host cells for Leishmania donovani, the causative agent of visceral leishmaniasis. In this study we sought to determine whether activated macrophages, as defined by the functional criterion of tumor cell cytotoxicity, were also able to exert a microbicidal effect on ingested L. donovani amastigotes.
C G, Haidaris, P F, Bonventre
openaire   +2 more sources

Synthesis and Evaluation of Peptoid‐Based Compound Libraries as Inhibitors of Parasite Metallo‐Aminopeptidases

ChemMedChem, Volume 21, Issue 17, 14 September 2026.
Evaluation of two libraries of peptoid‐based compounds for inhibitory activity against PfA‐M1 from Plasmodium falciparum, TcLAP from Trypanosoma cruzi, and LmLAP from Leishmania major reveals the crucial role of hydrophobic interactions in the inhibition process of these parasite metallo‐aminopeptidases.
Mirta Elisa Aguado, Gerardo M. Ojeda‐Carralero, Mario Antonio Rodríguez, Isabella Rúa, Heisy Guerra, Edoardo Bailo Hernández, Guglielmo Coppola, Susana Alberti, Ariatne Rodríguez, Maikel Izquierdo, Christian Betzel, Filippo Pettazzi, Julieta Coro‐Bermello, Erik V. Van der Eycken, Bernhard Westermann, Jorge González‐Bacerio, Daniel G. Rivera   +16 more
wiley   +1 more source

Glycosylphosphatidylinositols are required for the development of Trypanosoma cruzi amastigotes [PDF]

Infection and Immunity, 1997
Induction of a glycosylphosphatidylinositol (GPI) deficiency in Trypanosoma cruzi by the heterologous expression of Trypanosoma brucei GPI-phospholipase C (GPI-PLC) results in decreased expression of major surface proteins (N. Garg, R. L. Tarleton, and K. Mensa-Wilmot, J. Biol. Chem. 272:12482-12491, 1997).
N, Garg, M, Postan, K, Mensa-Wilmot, R L, Tarleton   +3 more
openaire   +2 more sources

Therapeutic Effects of Matricaria chamomilla Extract in an Immunosuppressed Mouse Model of Cryptosporidiosis

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
Chamomile (Matricaria chamomilla) extract significantly reduced oocyst shedding and intestinal lesions in immunosuppressed mice infected with Cryptosporidium parvum, while enhancing antioxidant defences (GPx, TAC). These findings suggest chamomile as a promising phytotherapeutic agent for cryptosporidiosis. ABSTRACT Background Cryptosporidiosis, caused
Kousha Kiani, Mohammad Hashemnia, Farid Rezaei, Hadi Cheraghi   +3 more
wiley   +1 more source

Cutaneous leishmaniosis in a dog vaccinated with LiESP/QA-21: effective or defective vaccine-related immune surveillance? A case report

Veterinární Medicína, 2017
Leishmania, an intracellular protozoan parasite, is endemic, widespread and represents a public health problem in most countries of the Mediterranean basin as it is implicated in a wide spectrum of diseases both in humans and animals.
A. de Cosmo, D. Mazzoni, A. Campanati, G.E. Magi, D. Beghelli   +4 more
doaj   +1 more source

Different Transcriptomic Responses After Moderate and Severe Heat Shock in Trypanosoma cruzi Epimastigotes

Journal of Eukaryotic Microbiology, Volume 73, Issue 5, September/October 2026.
ABSTRACT Trypanosoma cruzi undergoes heat stress during its life cycle. In this study, we performed a transcriptomic analysis of the heat shock response in epimastigotes from different T. cruzi strains. In both clone CL Brener and the Y strain, very few to no statistically significant variations were observed in the transcriptome at 37°C, whereas ...
Thayane Bottaro, Luciana L. Penha, Rosane Silva, Turán P. Ürményi   +3 more
wiley   +1 more source

Re-description of Trypanosoma corvi Stephens and Christophers,1908 Emend. Baker, 1976 and remarks on the Trypanosomes of the Avian Family Corvidae

Memorias do Instituto Oswaldo Cruz, 1994
The trypomastigote, epimastigote and amastigote stages of Trypanosoma corvi Stephens and Christophers, 1908 emend. Baker, 1976 from the peripheral blood, heart and bone marrow are described herein.
N. C. Nandi, Gordon F. Bennett
doaj   +1 more source

Administration of artinm lectin reduces the severity of the acute phase infection with Trypanosoma cruzi

FASEB BioAdvances, 2021
The acute phase of experimental Trypanosoma cruzi infection is associated with a strong inflammatory reaction, physiological changes, amastigote nests in tissues, and hematological alterations.
Camila Botelho Miguel, Thiago Aparecido da silva, Wellington Francisco Rodrigues, Patrícia Kellen Martins Oliveira‐Brito, Maria Cristina Roque‐Barreira, Javier Emílio Lazo‐Chica   +5 more
doaj   +1 more source

Synthesis and Antiparasitic Activities of New Organometallic Derivatives of the Benzimidazole Anthelmintic Drugs

ChemBioChem, Volume 27, Issue 15, 14 August 2026.
Organometallic derivatization of existing drugs is a common strategy to look for new drug candidates. This work describes the derivatization of the benzimidazole anthelmintic scaffold, from the synthesis of the organometallic derivatives to the evaluation of their biological properties. It highlights a broad range of antiparasitic activities and leaves
Corentin Ludwig, Aya C. Taki, Joseph J. Byrne, Pierre Mesdom, Olivier Blacque, Cécile Häberli, Trix Zumkehr, Gonzalo Scalese, Leticia Pérez‐Díaz, Dinorah Gambino, Britta Lundström‐Stadelmann, Jennifer Keiser, Robin B. Gasser, Kevin Cariou, Gilles Gasser   +14 more
wiley   +1 more source

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

Advanced Healthcare Materials, Volume 15, Issue 30, 14 August 2026.
Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano, M. Carmen Mera‐Delgado, Esther Moreno, Esther Larrea, Lecnia Aguirre, Jonathan Miguel Zanatta, Sónia Barros‐Carvalho, Iola F. Duarte, Ricardo Silvestre, Juan M. Irache, Javier Carrión, Socorro Espuelas   +11 more
wiley   +1 more source