Results 51 to 60 of about 12,502 (214)

Identification of sialic acids on Leishmania donovani amastigotes [PDF]

Biological Chemistry, 2004
AbstractThe presence of Neu5Ac on promastigotes of Leishmania donovani, the causative organism of Indian visceral leishmaniasis, has been reported recently. Here we report the occurrence of Neu5Ac as a major component on amastigotes, as well as Neu5Gc, Neu5,9Ac2 and Neu9Ac5Gc as indicated by fluorimetric high performance liquid chromatography and gas ...
Chava, A.K., Chatterjee, M., Gerwig, G.J., Kamerling, J.P., Mandal, C.   +4 more
openaire   +4 more sources

Inhibition of HSP90 distinctively modulates the global phosphoproteome of Leishmania mexicana developmental stages

Microbiology Spectrum, 2023
Heat shock protein 90 (HSP90) is an evolutionarily conserved chaperone protein that plays a central role in the folding and maturation of a large array of client proteins.
Exequiel O. Porta, Liqian Gao, Paul W. Denny, Patrick G. Steel, Karunakaran Kalesh   +4 more
doaj   +1 more source

Therapeutic Effects of Matricaria chamomilla Extract in an Immunosuppressed Mouse Model of Cryptosporidiosis

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
Chamomile (Matricaria chamomilla) extract significantly reduced oocyst shedding and intestinal lesions in immunosuppressed mice infected with Cryptosporidium parvum, while enhancing antioxidant defences (GPx, TAC). These findings suggest chamomile as a promising phytotherapeutic agent for cryptosporidiosis. ABSTRACT Background Cryptosporidiosis, caused
Kousha Kiani, Mohammad Hashemnia, Farid Rezaei, Hadi Cheraghi   +3 more
wiley   +1 more source

Synthesis of Xylitan Derivatives and Preliminary Evaluation of in Vitro Trypanocidal Activity

Molecules, 2016
A series of novel xylitan derivatives derived from xylitol were synthesized using operationally simple procedures. A xylitan acetonide was the key intermediate used to prepare benzoate, arylsulfonate esters and 1,2,3-triazole derivatives of xylitan ...
Paula Regina Elias, Gleicekelly Silva Coelho, Viviane Flores Xavier, Policarpo Ademar Sales Junior, Alvaro José Romanha, Silvane Maria Fonseca Murta, Claudia Martins Carneiro, Nilton Soares Camilo, Flaviane Francisco Hilário, Jason Guy Taylor   +9 more
doaj   +1 more source

Different Transcriptomic Responses After Moderate and Severe Heat Shock in Trypanosoma cruzi Epimastigotes

Journal of Eukaryotic Microbiology, Volume 73, Issue 5, September/October 2026.
ABSTRACT Trypanosoma cruzi undergoes heat stress during its life cycle. In this study, we performed a transcriptomic analysis of the heat shock response in epimastigotes from different T. cruzi strains. In both clone CL Brener and the Y strain, very few to no statistically significant variations were observed in the transcriptome at 37°C, whereas ...
Thayane Bottaro, Luciana L. Penha, Rosane Silva, Turán P. Ürményi   +3 more
wiley   +1 more source

In vitro models in drug discovery and development for leishmaniasis: A perspective

Annals of Medical Science and Research
The intracellular Leishmania amastigote model (ILAM) has been instrumental in advancing drug discovery for leishmaniasis treatment over the past 40 years.
Simon L. Croft, Katrien Van Bocxlaer
doaj   +1 more source

Translational control through eIF2alpha phosphorylation during the Leishmania differentiation process. [PDF]

PLoS ONE, 2012
The parasitic protozoan Leishmania alternates between an invertebrate and a mammalian host. Upon their entry to mammalian macrophages, Leishmania promastigotes differentiate into amastigote forms within the harsh environment of the phagolysosomal ...
Serge Cloutier, Maxime Laverdière, Marie-Noelle Chou, Nathalie Boilard, Conan Chow, Barbara Papadopoulou   +5 more
doaj   +1 more source

Biochemical analysis and immunogenicity of Leishmania major amastigote fractions in cutaneous leishmaniasis

, 1997
SUMMARY Soluble Leishmania antigen (SLA) from both developmental stages of L. major (L. major MRHO/IR/75/ ER) were prepared. Three and five subfractions of SLA from amastigote and promastigote were obtained by fast protein liquid ...
M H ALIMOHAMMADIAN, J A LOUIS, S RAFATI, S COUTY-JOUVE   +3 more
core   +1 more source

Synthesis and Antiparasitic Activities of New Organometallic Derivatives of the Benzimidazole Anthelmintic Drugs

ChemBioChem, Volume 27, Issue 15, 14 August 2026.
Organometallic derivatization of existing drugs is a common strategy to look for new drug candidates. This work describes the derivatization of the benzimidazole anthelmintic scaffold, from the synthesis of the organometallic derivatives to the evaluation of their biological properties. It highlights a broad range of antiparasitic activities and leaves
Corentin Ludwig, Aya C. Taki, Joseph J. Byrne, Pierre Mesdom, Olivier Blacque, Cécile Häberli, Trix Zumkehr, Gonzalo Scalese, Leticia Pérez‐Díaz, Dinorah Gambino, Britta Lundström‐Stadelmann, Jennifer Keiser, Robin B. Gasser, Kevin Cariou, Gilles Gasser   +14 more
wiley   +1 more source

Elimination of Leishmania donovani amastigotes by activated macrophages [PDF]

Infection and Immunity, 1981
Tissue macrophages are the obligatory host cells for Leishmania donovani, the causative agent of visceral leishmaniasis. In this study we sought to determine whether activated macrophages, as defined by the functional criterion of tumor cell cytotoxicity, were also able to exert a microbicidal effect on ingested L. donovani amastigotes.
C G, Haidaris, P F, Bonventre
openaire   +2 more sources