Results 71 to 80 of about 12,502 (214)

CD4+ T Cell-Dependent Macrophage Activation Modulates Sustained PS Exposure on Intracellular Amastigotes of Leishmania amazonensis

Frontiers in Cellular and Infection Microbiology, 2019
Leishmania amazonensis amastigotes can make use of surface-exposed phosphatidylserine (PS) molecules to promote infection and non-classical activation of macrophages (MΦ), leading to uncontrolled intracellular proliferation of the parasites.
Joao Luiz Mendes Wanderley, Poliana Deolindo, Eric Carlsen, Arieli Bernardo Portugal, Renato Augusto DaMatta, Marcello Andre Barcinski, Lynn Soong   +6 more
doaj   +1 more source

Identification of a Benzenesulfonylpiperazine Derivative With In Vivo Efficacy Against Visceral Leishmaniasis

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
This work highlights the satisfactory pharmacokinetic profile of two benzenesulfonylpiperazine lead candidates, followed by in vivo assessment in a murine model of visceral leishmaniasis. This assessment identified compound 2 as moderately active at a lower dose, but its efficacy increased at higher doses, though with concerns regarding safety.
Thibault Joseph William Jacques Dit Lapierre, Mariza Gabriela Faleiro de Moura Lodi Cruz, Guilherme Freitas de Lima Hercos, Rafael Consolin Chelucci, Simone Michelan‐Duarte, Gisele Barbosa, Analu R. Costa, Miguel Angel Chávez‐Fumagalli, Paula Derksen Macruz, Eduardo Jorge Pilau, Leonardo L. G. Ferreira, Adriano D. Andricopulo, Silvane Maria Fonseca Murta, Celso de Oliveira Rezende Júnior   +13 more
wiley   +1 more source

An Observation of the Transitional Forms between Trypomastigote and Amastigote of Trypanosoma cruzi by Scanning Electronmicroscopy [PDF]

, 1991
The transformation process between the trypomastigote and the amastigote was studied by Scanning Electronmicroscopy (SEM). The exclusive process from the trypomastigote to the amastigote was accomplished by incubating trypomastigotes in LIT medium while ...
Fukuma, Toshihide, Kanbara, Hiroji, Nakazawa, Shusuke, Sooksri, Varunee   +3 more
core   +1 more source

Leishmanicidal Activity and Cytotoxicity of Thymus kotschyanus Hydroalcoholic Extract: an In Vitro Assessment [PDF]

Research Journal of Pharmacognosy
Background and objectives: Current leishmaniasis treatment shows limitations such as side effects, low efficacy, and resistance. Thymus species are well-known as medicinal plants.
Maryam Nematollahi, Amir Mehdi Taleb, Seyyed Javad Seyyed-Tabaei, Nayebali Ahmadi*   +3 more
doaj   +1 more source

Vectors and Vector‐Borne Diseases: Biology, Epidemiology and Integrated Control Strategies

Journal of Applied Entomology, Volume 150, Issue 7, Page 990-1015, August 2026.
ABSTRACT Vector‐Borne Diseases (VBDs), transmitted by arthropods such as mosquitoes, ticks, fleas and sandflies, represent a significant threat to global health. These diseases can be caused by a variety of pathogens, including bacteria, viruses, protozoa, and helminths.
Roberta Rinaldi, Carmen Scieuzo, Federica De Stefano, Luca Masucci, Patrizia Falabella   +4 more
wiley   +1 more source

Extracellular cultivation and morphological characterization of amastigote-like forms of Leishmania panamensis and L. braziliensis

, 1989
Two strains of the Leishmania braziliensis complex have been adapted to grow extracellularly at elevated temperature as amastigote-like forms in a cell-free medium.
McMahon-Pratt, D., Eperon, S.
core   +1 more source

Estimation of antiparasitic activity of fungal extracts towards Leishmania donovani in murine model [PDF]

Romanian Journal of Infectious Diseases
Background. Fungi produce many compounds have pharmaceutical usage. The current study was aimed to extract therapeutic compounds from fungi that grow in critical conditions and fungi that can be produced commercially which may have potential therapeutic ...
Aseel Al-Musa, Muslim A.M. Altooma, Inaam M.N. Alrubayae   +2 more
doaj   +1 more source

Recombinant LPG3 Protein From Leishmania chagasi as an Antigen for the Diagnosis of Canine Visceral Leishmaniasis

Tropical Medicine &International Health, Volume 31, Issue 8, Page 1057-1065, August 2026.
ABSTRACT Visceral leishmaniasis (VL) is a human neglected tropical disease in which dogs participate as reservoirs of the etiological agent Leishmania chagasi. The identification of infected dogs is important to the control of VL, and recombinant proteins are strong antigen candidates for canine visceral leishmaniasis (CVL) serodiagnosis. In this work,
Thaís Viana Fialho Martins, Anna Cláudia Alves de Souza, Bianca Meireles Miranda, Ronny Francisco de Souza, Daniel Silva Sena Bastos, Neverton José Silva Ferreira, Tiago Antônio de Oliveira Mendes, Celeste da Silva Freitas de Souza, George Luiz Lins Machado‐Coelho, Maria Terezinha Bahia, Leandro Licursi de Oliveira, Juliana Lopes Rangel Fietto, Eduardo de Almeida Marques‐da‐Silva   +12 more
wiley   +1 more source

Timing of developmental changes associated with amastigote differentiation in PEMs.

, 2022
(A) Parasite flagella were identified at different time points following infection of PEMs with anti-LPG (≤ 8 h post infection) or mAb T17 at longer time points.
Stephen M. Beverley (174720), Michael A. Mandell (9519716), Wandy L. Beatty (11060349)   +2 more
core   +1 more source

Compared Antileishmanial Activity of Clomiphene and Tamoxifen

Biomedicines
Drug repositioning is an efficient strategy to search for new treatment alternatives that is especially valuable for neglected parasitic diseases such as leishmaniasis. Tamoxifen and raloxifene are selective estrogen receptor modulators (SERMs) that have
Sergio Sifontes-Rodríguez, Alma Reyna Escalona-Montaño, Ricardo Mondragón Flores, Niurka Mollineda-Diogo, Lianet Monzote Fidalgo, Mónica Edith Mondragón-Castelán, Fedra Alardin-Gutiérrez, Lourdes Araceli López-Enzana, Daniel Andrés Sánchez-Almaraz, Ofelia Pérez-Olvera, María Magdalena Aguirre-García   +10 more
doaj   +1 more source