Results 81 to 90 of about 12,502 (214)

Microscopic identification of Leishmania amastigote forms.

, 2016
Biological samples obtained from ulcer were stained by Giemsa technique. (A) image of a peripheral lesion biopsy; (B) image of a deep lesion biopsy. The amastigote forms are indicating by arrows.
Carlos De Petris (2558476), David Dib (2558485), Jose Echenique (2558479), Paulo R. Cortes (229783), Laura S. Chiapello (2558491), Monica V. Herrero (2558488), Carmen T. Nuncira (2558482)   +6 more
core   +1 more source

RNA synthesis in Leishmania donovani is constitutive during stage conversion: a genome-wide PRO-seq analysis

Microbiology Spectrum
Transcription in Leishmania donovani has long been considered constitutive, as shown by nuclear run-on analyses and northern blots, with gene expression primarily regulated post-transcriptionally.
Janne Grünebast, Stephan Lorenzen, Christine Brinker, Annika Bea, Joachim Clos   +4 more
doaj   +1 more source

Arginine and Polyamines Fate in Leishmania Infection

Frontiers in Microbiology, 2018
Leishmania is a protozoan parasite that alternates its life cycle between the sand fly and the mammalian host macrophages, involving several environmental changes.
Sandra M. Muxel, Juliana I. Aoki, Juliane C. R. Fernandes, Maria F. Laranjeira-Silva, Ricardo A. Zampieri, Stephanie M. Acuña, Karl E. Müller, Rubia H. Vanderlinde, Lucile M. Floeter-Winter   +8 more
doaj   +1 more source

The role of the Leishmania mexicana amastigote flagellum in parasite-host interactions [PDF]

, 2019
Cilia and flagella are important organelles with roles in motility and signalling across eukaryotes. Leishmania species possess both a motile 9+2 flagellum and an immotile 9+0 flagellum in different lifecycle stages. While several roles have been defined
Valli, Jessica
core   +1 more source

Striking Bone Marrow Plasmacytosis Resulting From Visceral Leishmaniasis

American Journal of Hematology, Volume 101, Issue 8, Page 2007-2008, August 2026.
Vishakha Sovani, Jennifer Ryan, Barbara J. Bain   +2 more
wiley   +1 more source

Biochemical analysis and immunogenicity of Leishmania major amastigote fractions in cutaneous leishmaniasis.

, 1997
Soluble Leishmania antigen (SLA) from both developmental stages of L. major (L. major MRHO/IR/75/ER) were prepared. Three and five subfractions of SLA from amastigote and promastigote were obtained by fast protein liquid chromatography (FPLC ...
Couty-Jouve, S., Louis, J.A., Rafati, S., Alimohammadian, M.H.   +3 more
core   +1 more source

Application of nano and microformulations to improve the leishmanicidal response of quinoline compounds: a brief review

Frontiers in Chemistry
The quinolines represent an important scaffold for the development of leishmanicidal agents. In particular, the use of nano and microformulations has emerged as a powerful tool to improve the therapeutic profile of leishmanicidal drugs, favoring ...
Angel H. Romero, Karina N. Gonzalez, Karina N. Gonzalez, Marcos A. Sabino   +3 more
doaj   +1 more source

Utilization of proliferable extracellular amastigotes for transient gene expression, drug sensitivity assay, and CRISPR/Cas9-mediated gene knockout in Trypanosoma cruzi.

PLoS Neglected Tropical Diseases, 2019
Trypanosoma cruzi has three distinct life cycle stages; epimastigote, trypomastigote, and amastigote. Amastigote is the replication stage in host mammalian cells, hence this stage of parasite has clinical significance in drug development research ...
Yuko Takagi, Yukie Akutsu, Motomichi Doi, Koji Furukawa   +3 more
doaj   +1 more source

An image-based high-content screening assay for compounds targeting intracellular Leishmania donovani amastigotes in human macrophages.

PLoS Neglected Tropical Diseases, 2012
Leishmaniasis is a tropical disease threatening 350 million people from endemic regions. The available drugs for treatment are inadequate, with limitations such as serious side effects, parasite resistance or high cost. Driven by this need for new drugs,
Jair L Siqueira-Neto, Seunghyun Moon, Jiyeon Jang, Gyongseon Yang, Changbok Lee, Hong Kee Moon, Eric Chatelain, Auguste Genovesio, Jonathan Cechetto, Lucio H Freitas-Junior   +9 more
doaj   +1 more source

The life cycle of Leishmania amazonensis (A), and structural organization of the promastigote (B) and amastigote (C) forms.

, 2013
(A) The female sandfly (1) insect bites an infected mammal during the blood meal. Infected macrophages (2) with amastigote forms. (3) Amastigote form. (4) Amastigotes transform into procyclic promastigotes.
Marlene Benchimol (154437), Dirceu E. Teixeira (309881), Wanderley de Souza (87693), Paulo F. P. Pimenta (198387), Juliany C. F. Rodrigues (223549), Paulo H. Crepaldi (469185)   +5 more
core   +1 more source