Results 61 to 70 of about 8,500 (184)

CD4+ T Cell-Dependent Macrophage Activation Modulates Sustained PS Exposure on Intracellular Amastigotes of Leishmania amazonensis

Frontiers in Cellular and Infection Microbiology, 2019
Leishmania amazonensis amastigotes can make use of surface-exposed phosphatidylserine (PS) molecules to promote infection and non-classical activation of macrophages (MΦ), leading to uncontrolled intracellular proliferation of the parasites.
Joao Luiz Mendes Wanderley, Poliana Deolindo, Eric Carlsen, Arieli Bernardo Portugal, Renato Augusto DaMatta, Marcello Andre Barcinski, Lynn Soong   +6 more
doaj   +1 more source

Leishmanicidal Activity and Cytotoxicity of Thymus kotschyanus Hydroalcoholic Extract: an In Vitro Assessment [PDF]

Research Journal of Pharmacognosy
Background and objectives: Current leishmaniasis treatment shows limitations such as side effects, low efficacy, and resistance. Thymus species are well-known as medicinal plants.
Maryam Nematollahi, Amir Mehdi Taleb, Seyyed Javad Seyyed-Tabaei, Nayebali Ahmadi*   +3 more
doaj   +1 more source

Estimation of antiparasitic activity of fungal extracts towards Leishmania donovani in murine model [PDF]

Romanian Journal of Infectious Diseases
Background. Fungi produce many compounds have pharmaceutical usage. The current study was aimed to extract therapeutic compounds from fungi that grow in critical conditions and fungi that can be produced commercially which may have potential therapeutic ...
Aseel Al-Musa, Muslim A.M. Altooma, Inaam M.N. Alrubayae   +2 more
doaj   +1 more source

Compared Antileishmanial Activity of Clomiphene and Tamoxifen

Biomedicines
Drug repositioning is an efficient strategy to search for new treatment alternatives that is especially valuable for neglected parasitic diseases such as leishmaniasis. Tamoxifen and raloxifene are selective estrogen receptor modulators (SERMs) that have
Sergio Sifontes-Rodríguez, Alma Reyna Escalona-Montaño, Ricardo Mondragón Flores, Niurka Mollineda-Diogo, Lianet Monzote Fidalgo, Mónica Edith Mondragón-Castelán, Fedra Alardin-Gutiérrez, Lourdes Araceli López-Enzana, Daniel Andrés Sánchez-Almaraz, Ofelia Pérez-Olvera, María Magdalena Aguirre-García   +10 more
doaj   +1 more source

Hepatic Mechanisms and Therapeutic Target Underpinning Hypercoagulation in Obesity: Insights From Genetic and Transcriptomic Analyses

Exploration, Volume 6, Issue 4, August 2026.
Obesity‐linked hypercoagulation is driven by fibrinogen overproduction in a specific hepatocyte cluster via IL6 signalling. Genetic and mechanistic studies reveal this pathway as a key target for therapies to mitigate clotting risks and associated complications in obese individuals.
Shumin Li, Gengchen Feng, Xin Huang, Xiao Teng, Ziyi Yang, Yue Liu, Yonghui Jiang, Tao Zhu, Teng Liu, Yunfei Xu, Chang Pan, Han Zhao, Shaozhuang Liu, Shigang Zhao, Zi‐Jiang Chen   +14 more
wiley   +1 more source

RNA synthesis in Leishmania donovani is constitutive during stage conversion: a genome-wide PRO-seq analysis

Microbiology Spectrum
Transcription in Leishmania donovani has long been considered constitutive, as shown by nuclear run-on analyses and northern blots, with gene expression primarily regulated post-transcriptionally.
Janne Grünebast, Stephan Lorenzen, Christine Brinker, Annika Bea, Joachim Clos   +4 more
doaj   +1 more source

Arginine and Polyamines Fate in Leishmania Infection

Frontiers in Microbiology, 2018
Leishmania is a protozoan parasite that alternates its life cycle between the sand fly and the mammalian host macrophages, involving several environmental changes.
Sandra M. Muxel, Juliana I. Aoki, Juliane C. R. Fernandes, Maria F. Laranjeira-Silva, Ricardo A. Zampieri, Stephanie M. Acuña, Karl E. Müller, Rubia H. Vanderlinde, Lucile M. Floeter-Winter   +8 more
doaj   +1 more source

Application of nano and microformulations to improve the leishmanicidal response of quinoline compounds: a brief review

Frontiers in Chemistry
The quinolines represent an important scaffold for the development of leishmanicidal agents. In particular, the use of nano and microformulations has emerged as a powerful tool to improve the therapeutic profile of leishmanicidal drugs, favoring ...
Angel H. Romero, Karina N. Gonzalez, Karina N. Gonzalez, Marcos A. Sabino   +3 more
doaj   +1 more source

Striking Bone Marrow Plasmacytosis Resulting From Visceral Leishmaniasis

American Journal of Hematology, Volume 101, Issue 8, Page 2007-2008, August 2026.
Vishakha Sovani, Jennifer Ryan, Barbara J. Bain   +2 more
wiley   +1 more source

Utilization of proliferable extracellular amastigotes for transient gene expression, drug sensitivity assay, and CRISPR/Cas9-mediated gene knockout in Trypanosoma cruzi.

PLoS Neglected Tropical Diseases, 2019
Trypanosoma cruzi has three distinct life cycle stages; epimastigote, trypomastigote, and amastigote. Amastigote is the replication stage in host mammalian cells, hence this stage of parasite has clinical significance in drug development research ...
Yuko Takagi, Yukie Akutsu, Motomichi Doi, Koji Furukawa   +3 more
doaj   +1 more source