An axenic amastigote system for drug screening [PDF]
Antimicrobial Agents and Chemotherapy, 1997 Currently available primary screens for selection of candidate antileishmanial compounds are not ideal. The choices include screens that are designed to closely reflect the situation in vivo but are labor-intensive and expensive (intracellular amastigotes and animal models) and screens that are designed to facilitate rapid testing of a large number of ...
H L, Callahan +3 more
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The hows and whys of amastigote flagellum motility in Trypanosoma cruzi
mBio, 2023 The protist Trypanosoma cruzi exhibits several extracellular stages characterized by the presence of a long and motile flagellum and one intracellular life cycle stage termed amastigote, which possesses a tiny flagellum barely exiting the flagellar ...
Aline Araujo Alves, Philippe Bastin
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Trypanosoma cruzi: amastigote polymorphism defined by monoclonal antibodies
Brazilian Journal of Medical and Biological Research, 1998 We have raised monoclonal antibodies (mAbs) directed towards amastigote forms of Trypanosoma cruzi, and shown that mAbs 1D9 and 4B9 are carbohydrate while mAb 4B5 activity is resistant to periodate oxidation of the antigen.
N.V. Verbisck, S. Da-Silva, R.A. Mortara
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Chitosan-Based Nanomaterials as Valuable Sources of Anti-Leishmanial Agents: A Systematic Review
Nanomaterials, 2021 Background: The current chemotherapy agents against various forms of leishmaniasis have some problems and side effects, including high toxicity, high cost, and the emergence of resistant strains. Here, we aimed to review the preclinical studies (in vitro
Hamdan I. AlMohammed +6 more
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Experimental induction of paromomycin resistance in antimony-resistant strains of L. donovani : outcome dependent on in vitro selection protocol [PDF]
, 2012 Paromomycin (PMM) has recently been introduced for treatment of visceral leishmaniasis in India. Although no clinical resistance has yet been reported, proactive vigilance should be warranted. The present in vitro study compared the outcome and stability
Salotra, P. +12 more
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Endocytosis and Sphingolipid Scavenging inLeishmania mexicanaAmastigotes [PDF]
Biochemistry Research International, 2012 Leishmaniaspecies are the causative agents of the leishmaniases, a spectrum of neglected tropical diseases. Amastigote stage parasites exist within macrophages and scavenge host factors for survival, for example,Leishmaniaspecies utilise host sphingolipid for synthesis of complex sphingolipid. In this studyL.
Ali, Hayder Z. +2 more
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Journal of Experimental Pharmacology, 2023 Tasisa Ketema,1 Markos Tadele,2 Zewdie Gebrie,1 Eyasu Makonnen,1,3 Asrat Hailu,3,4 Solomon M Abay1 1Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Science, Addis Ababa University, Addis Ababa, Ethiopia; 2Animal ...
Ketema T +5 more
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Comparative study of the ability of Leishmania mexicana promastigotes and amastigotes to alter macrophage signalling and functions [PDF]
, 2010 Leishmania alternates between two morphologically different stages: promastigotes and amastigotes. While the majority of reports focused on how the promastigote form can alter macrophage signalling and function, fewer reports investigated signalling ...
Hassani, K. +9 more
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Arrows pointing to amastigote forms of Leishmania spp.
, 2022 Arrows pointing to amastigote forms of Leishmania spp.
Muhammad Taimur (12647080) +7 more
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In vitro and in vivo effects of Astragalus ecbatanus extract against cutaneous leishmaniasis [PDF]
Archives of Razi InstituteDue to the unique properties of Astragalus in the treatment of diseases and strengthening the immune system, for the first time, this study tried to study the in vitro and in vivo leishmanicidal effects of chloroform extract of A.
Seyedeh Negar Taheri +4 more
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