Results 21 to 30 of about 8,500 (184)
Endocytosis and Sphingolipid Scavenging inLeishmania mexicanaAmastigotes [PDF]
Biochemistry Research International, 2012 Leishmaniaspecies are the causative agents of the leishmaniases, a spectrum of neglected tropical diseases. Amastigote stage parasites exist within macrophages and scavenge host factors for survival, for example,Leishmaniaspecies utilise host sphingolipid for synthesis of complex sphingolipid. In this studyL.
Ali, Hayder Z. +2 more
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Journal of Experimental Pharmacology, 2023 Tasisa Ketema,1 Markos Tadele,2 Zewdie Gebrie,1 Eyasu Makonnen,1,3 Asrat Hailu,3,4 Solomon M Abay1 1Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Science, Addis Ababa University, Addis Ababa, Ethiopia; 2Animal ...
Ketema T +5 more
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In vitro and in vivo effects of Astragalus ecbatanus extract against cutaneous leishmaniasis [PDF]
Archives of Razi InstituteDue to the unique properties of Astragalus in the treatment of diseases and strengthening the immune system, for the first time, this study tried to study the in vitro and in vivo leishmanicidal effects of chloroform extract of A.
Seyedeh Negar Taheri +4 more
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mBio, 2018 The mammalian stages of the parasite Trypanosoma cruzi, the causative agent of Chagas disease, exhibit a wide host species range and extensive within-host tissue distribution.
Peter C. Dumoulin, Barbara A. Burleigh
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Microorganisms, 2021 This experimental investigation was designed to assess the in vitro and in vivo antileishmanial effects of Z. spina-christi methanolic extract (ZSCME) and also aims to assess some of the antileishmanial mechanisms such as the NO production, apoptosis ...
Aishah E. Albalawi
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Türkiye Parazitoloji Dergisi, 2021 Objective:Because the protocols used in the treatment of leishmaniasis can be toxic and have many limitations, such as the development of resistance against such protocols, new treatment options are needed, especially against resistant patients.
Orçun Zorbozan +5 more
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A role for extracellular amastigotes in the immunopathology of Chagas disease [PDF]
Memórias do Instituto Oswaldo Cruz, 1999 In spite of the growing knowledge obtained about immune control of Trypanosoma cruzi infection, the mechanisms responsible for the variable clinico-pathological expression of Chagas disease remain unknown. In a twist from previous concepts, recent studies indicated that tissue parasitism is a pre-requisite for the development of chronic myocarditis ...
Julio Scharfstein, Alexandre Morrot
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New diarylsulfonamide inhibitors of Leishmania infantum amastigotes
International Journal for Parasitology: Drugs and Drug Resistance, 2021 New drugs against visceral leishmaniasis with mechanisms of action differing from existing treatments and with adequate cost, stability, and properties are urgently needed. No antitubulin drug is currently in the clinic against Leishmania infantum, the causative agent of visceral leishmaniasis in the Mediterranean area. We have designed and synthesized
Myriam González +5 more
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Memorias do Instituto Oswaldo Cruz, 2003 A massive and homogeneous amount of amastigote-like forms was detected in the stomodeal valve (SV) and the thoracic mid-gut (TMG) of Leishmania major-infected Phlebotomus papatasi, which received a second blood meal 13 to 21 days post-infection on ...
Nestor Añez +5 more
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Molecules, 2018 The spectrum and efficacy of available antileishmanial drugs is limited. In the present work we evaluated in vitro the antiproliferative activity of 11 compounds based on tetradentate polyamines compounds against three Leishmania species (L. braziliensis,
Kristína Urbanová +10 more
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