Results 11 to 20 of about 8,500 (184)

Perillic Acid Synergizes With the Miltefosine Leishmanicidal Effect Against Leishmania amazonensis. [PDF]

Parasite Immunol
ABSTRACT Perillic acid (PA), a monocyclic monoterpene derived from limonene, was evaluated for its leishmanicidal activity alone and in combination with miltefosine, as well as in its microemulsion‐based formulation. PA demonstrated synergistic activity with miltefosine and was effective against both promastigote and amastigote forms of Leishmania ...
Ferreira C, Paschoal M, Passos CLA, Silva KGH, Silva KCH, Saraiva EM, Soares DC.   +6 more
europepmc   +2 more sources

Dicentrine, an Aporphine Alkaloid From Ocotea langsdorffii, Induces Mitochondrial Dysfunction and Oxidative Stress in Leishmania (L.) infantum. [PDF]

Chem Biodivers
Dicentrine, an aporphine alkaloid, exhibits potent in vitro antileishmanial activity against Leishmania species with high selectivity and low macrophage cytotoxicity. Mechanistic studies reveal that the compound triggers parasite death possibly by inducing mitochondrial membrane disruption and oxidative stress.
de Freitas CS, da Silva EOS, Tristão DC, Antar GM, Lage DP, Abrão DM, Antinarelli LMR, Coimbra ES, Lago JHG, Coelho EAF.   +9 more
europepmc   +2 more sources

Murine T Cell-Dependent Response Affects Leishmania amazonensis Amastigote Survival and Virulence. [PDF]

Cell Biol Int
ABSTRACT Our group has previously described the infection course of Leishmania amazonensis in BALB/c and BALB/cnu/nu mice, which have distinct T‐cell dependent responses. In this study, lesion‐derived amastigotes exhibited differential protein expression in a host‐dependent manner.
Soares GHC, Barbosa GR, Stolf BS.
europepmc   +2 more sources

Amastigote Synapse: The Tricks of Trypanosoma cruzi Extracellular Amastigotes [PDF]

Frontiers in Microbiology, 2018
To complete its life cycle within the mammalian host, Trypanosoma cruzi, the agent of Chagas' disease, must enter cells. Trypomastigotes originating from the insect vector (metacyclic) or from infected cells (bloodstream/tissue culture-derived) are the classical infective forms of the parasite and enter mammalian cells in an actin-independent manner ...
Bonfim-Melo, Alexis, Ferreira, Eden R., Florentino, Pilar T.V., Mortara, Renato A.   +3 more
openaire   +6 more sources

Infectivity of amastigotes of Trypanosoma cruzi [PDF]

Revista do Instituto de Medicina Tropical de São Paulo, 1986
The infectivity amastigotes of Trypanosoma cruzi, isolated from the supernatant of the J774G8 macrophage-like cell line infected with trypomastigotes to normal macrophages in vitro was tested. After a period of 1 h of T. cruzi-macrophage interaction about 2% of the mouse peritoneal macrophages had ingested amastigotes.
Carvalho, Tecia Ulisses de, Souza, Wanderley de   +1 more
openaire   +4 more sources

An axenic amastigote system for drug screening [PDF]

Antimicrobial Agents and Chemotherapy, 1997
Currently available primary screens for selection of candidate antileishmanial compounds are not ideal. The choices include screens that are designed to closely reflect the situation in vivo but are labor-intensive and expensive (intracellular amastigotes and animal models) and screens that are designed to facilitate rapid testing of a large number of ...
H L, Callahan, A C, Portal, R, Devereaux, M, Grogl   +3 more
openaire   +2 more sources

Pyridyl-Thiazole-Thiosemicarbazones as Antitrypanosomatidae Agents: Design, Synthesis, and In Silico Profiling. [PDF]

ChemMedChem
A novel pyridine–thiazole derivative, Compound 8, exhibited potent dual antitrypanosomatid activity. It demonstrated remarkable in vitro efficacy against Trypanosoma cruzi (IC50 = 1.0 µM) and L. amazonensis (IC50 = 3.9 µM). Molecular docking studies suggested interactions with heme and multiple molecular targets.
Silva AJFSD, Olimpio DSDC, Sousa LMDS, Brondani GL, Silva TL, Silva WBL, Costa NTC, Hernandes MZ, Junior PAS, Pereira VRA, Leite ACL.   +10 more
europepmc   +2 more sources

The hows and whys of amastigote flagellum motility in Trypanosoma cruzi

mBio, 2023
The protist Trypanosoma cruzi exhibits several extracellular stages characterized by the presence of a long and motile flagellum and one intracellular life cycle stage termed amastigote, which possesses a tiny flagellum barely exiting the flagellar ...
Aline Araujo Alves, Philippe Bastin
doaj   +1 more source

Trypanosoma cruzi: amastigote polymorphism defined by monoclonal antibodies

Brazilian Journal of Medical and Biological Research, 1998
We have raised monoclonal antibodies (mAbs) directed towards amastigote forms of Trypanosoma cruzi, and shown that mAbs 1D9 and 4B9 are carbohydrate while mAb 4B5 activity is resistant to periodate oxidation of the antigen.
N.V. Verbisck, S. Da-Silva, R.A. Mortara
doaj   +1 more source

Chitosan-Based Nanomaterials as Valuable Sources of Anti-Leishmanial Agents: A Systematic Review

Nanomaterials, 2021
Background: The current chemotherapy agents against various forms of leishmaniasis have some problems and side effects, including high toxicity, high cost, and the emergence of resistant strains. Here, we aimed to review the preclinical studies (in vitro
Hamdan I. AlMohammed, Amal Khudair Khalaf, Aishah E. Albalawi, Abdullah D. Alanazi, Parastoo Baharvand, Ali Moghaddam, Hossein Mahmoudvand   +6 more
doaj   +1 more source