Results 71 to 80 of about 11,689 (228)
ChemBioChem, Volume 27, Issue 15, 14 August 2026.Organometallic derivatization of existing drugs is a common strategy to look for new drug candidates. This work describes the derivatization of the benzimidazole anthelmintic scaffold, from the synthesis of the organometallic derivatives to the evaluation of their biological properties. It highlights a broad range of antiparasitic activities and leaves
Corentin Ludwig +14 more
wiley +1 more source
, 2010 We demonstrate that a proteophosphoglycan-rich gel secreted by Leishmania infantum inside the midgut of Lutzomyia longipalpis sand flies (promastigote secretory gel) is regurgitated along with an average dose of 500 L.
Müller, Ingrid +7 more
core +1 more source
Antileishmanial activity of polycyclic derivatives
Parasite, 2005 33 polycyclic derivatives have been studied and tested on Leishmania donovani and L. major promastigotes. Their antileishmanial activity was assessed in vitro and an assay of their cytotoxicity was realized on human myelomonocytic cell line.
Sarciron M.E. +8 more
doaj +1 more source
Actinomycin Derivatives: Structural Diversification and Biological Activities
ChemMedChem, Volume 21, Issue 15, 14 August 2026.Actinomycins are chromopeptide antibiotics exhibiting remarkable structural diversity and broad bioactivity. This review traces their development from naturally occurring D‐, X‐, A‐, G‐, Y‐, and Z‐type analogs to precursor‐directed, synthetic, and semisynthetic derivatives.
Özge Can, Erdal Bedir
wiley +1 more source
ChemMedChem, Volume 21, Issue 15, 14 August 2026.Bioactive metabolites can remain hidden in negligible activity extracts. A statistical spectroscopy–driven dereplication workflow integrating the HeteroCovariance Approach (HetCA) and Statistical Total Correlation Spectroscopy (STOCSY) prioritized furofuran lignans in Artemisia arborescens, identifying three compounds with moderate antileishmanial ...
Olga Karoutzou +6 more
wiley +1 more source
Serial block face scanning electron microscopy dataset of cultured L. mexicana promastigote cells.
Serial block face scanning electron microscopy dataset of cultured L. mexicana promastigote cells.
Molly Hair (18071631) +7 more
core +1 more source
PLoS Neglected Tropical Diseases, 2020 The parasitophorous vacuoles (PVs) that insulate Leishmania spp. in host macrophages are vacuolar compartments wherein promastigote forms differentiate into amastigote that are the replicative form of the parasite and are also more resistant to host ...
Sandrine Cojean +2 more
doaj +1 more source
Advanced Healthcare Materials, Volume 15, Issue 30, 14 August 2026.Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano +11 more
wiley +1 more source
, 2019 Influence of flow rate on percentage infection at a L. major promastigote to macrophage ratio of 15:1.
Alec O’Keeffe (7037294) +5 more
core +1 more source
NATURAL PROMASTIGOTE INFECTION OF SAND-FLIES AND ITS FIRST OCCURRENCE IN SERGENTOMYIA DENTATA IN ARDABIL PROVINCE, NORTH WEST OF IRAN [PDF]
Iranian Journal of Public Health, 1997 Visceral leishmanisasis is endemic and zoonotic in several foci in Ardabil province, North West of Iran. The main objective of this study was to determine the natural promastigote infection of sand-flies in active seasons, during 1991-1995.
Y.Rassi +3 more
doaj +2 more sources