Results 31 to 40 of about 11,689 (228)

Leishmanicidal Activity and Cytotoxicity of Thymus kotschyanus Hydroalcoholic Extract: an In Vitro Assessment [PDF]

Research Journal of Pharmacognosy
Background and objectives: Current leishmaniasis treatment shows limitations such as side effects, low efficacy, and resistance. Thymus species are well-known as medicinal plants.
Maryam Nematollahi, Amir Mehdi Taleb, Seyyed Javad Seyyed-Tabaei, Nayebali Ahmadi*   +3 more
doaj   +1 more source

Anti-promastigote Activity of the Amazon Plants

, 2017
Universidade Federal do Pará. Programa de Pós-Graduação em Ciências Farmacêuticas. Belém, PA, Brasil.Universidade Federal do Pará. Programa de Pós-Graduação em Ciências Farmacêuticas. Belém, PA, Brasil.Universidade Federal do Pará.
null Silva, N. C. S., Dolabela, Maria Fâni, Silveira, Fernando Tobias, Silva, N. C. S., null Vale, V. V., null Silveira, F. T., null Brigido, H. P. C., Vale, Valdicley Vieira, null Silva-Silva, J. V., null Silvestre, J. V., Marinho, A. M. R., null Monteiro, R. C. S., Silva-Silva, João Victor, Silvestre, J. V., null Dolabela, M. F., Monteiro, R. C. S., null Marinho, A. M. R., Brígido, Helliton Patrick Cordovil   +17 more
core   +1 more source

Natural Infection by Toscana Virus and Other Phleboviruses in Wild Sand Flies From Spain: Prevalence, Genetic Characterization and Tripartite Interactions With Leishmania infantum and Wolbachia

Zoonoses and Public Health, Volume 73, Issue 7, Page 655-669, November 2026.
ABSTRACT Introduction Toscana virus (TOSV) and Leishmania species are sand fly‐borne pathogens that pose a significant public health threat and an increasing risk of exposure in Europe. The objective of this study was to identify the phleboviruses circulating in an area endemic for sand fly‐borne pathogens and to estimate infection prevalence in wild ...
Andrés Torres‐Llamas, Antonio Sampedro, Victoriano Díaz‐Sáez, Manuel Morales‐Yuste, Javier Rodríguez‐Granger, Irene Pedrosa‐Corral, José María Navarro‐Marí, Francisco Morillas‐Márquez, Joaquina Martín‐Sánchez   +8 more
wiley   +1 more source

Arginine and Polyamines Fate in Leishmania Infection

Frontiers in Microbiology, 2018
Leishmania is a protozoan parasite that alternates its life cycle between the sand fly and the mammalian host macrophages, involving several environmental changes.
Sandra M. Muxel, Juliana I. Aoki, Juliane C. R. Fernandes, Maria F. Laranjeira-Silva, Ricardo A. Zampieri, Stephanie M. Acuña, Karl E. Müller, Rubia H. Vanderlinde, Lucile M. Floeter-Winter   +8 more
doaj   +1 more source

Synthesis, Antiparasitic Activity, and ADME Profile of Morpholinephenylbenzamides: A Pharmacological Study Against Chagas Disease and Visceral Leishmaniasis

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Hit‐to‐lead optimization of morpholinephenylbenzamides reveals key structure–activity relationships against Trypanosoma cruzi and Leishmania infantum. Potency, selectivity, and ADME properties are differentially improved across the series, identifying compounds 20, 24, and 16 as complementary templates for the future design of dual antiparasitic leads.
Danilo Nascimento Farago, Daniela de Melo Resende, Mariza Gabriela Faleiro de Moura Lodi Cruz, Rafaela Marçal Sousa, Rafael Consolin Chelucci, Simone Michelan‐Duarte, Felipe da Silva Mendonça de Melo, Douglas Davison da Silva Oliveira, Paula Derksen Macruz, Alexandra Maria dos Santos Carvalho, Eduardo Jorge Pilau, Izabela Marques Dourado Bastos, Adriano D. Andricopulo, Leonardo L. G. Ferreira, Silvane Maria Fonseca Murta, Celso de Oliveira Rezende Júnior   +15 more
wiley   +1 more source

Comparative IC₅₀ for 2HF against wild-type and antimony-resistant L. amazonensis promastigote.

, 2018
Comparative IC50 for 2HF against wild-type and antimony-resistant L. amazonensis promastigote.
Elmo E. Almeida-Amaral (619692), Gabriella Gonçalves-Ozório (6057236), Luiza F. O. Gervazoni (6057233)   +2 more
core   +1 more source

The Eukaryotic Elongation Factor 1 Alpha (eEF1α) from the Parasite Leishmania infantum Is Modified with the Immunomodulatory Substituent Phosphorylcholine (PC)

Molecules, 2017
Proteins and glycolipids have been found to be decorated with phosphorylcholine (PC) both in protozoa and nematodes that parasitize humans and animals. PC epitopes can provoke various effects on immune cells leading to an immunomodulation of the host’s ...
Thomas Timm, Giada Annoscia, Jochen Klein, Günter Lochnit   +3 more
doaj   +1 more source

Biological Evaluation, Molecular Docking, MD Simulation Study and Synthesis of (Z)‐N’‐(3‐phenoxybenzylidene)‐2‐(substituted‐amino aryl) Acetohydrazid

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
Synthesis and biological evaluation (antibacterial, antifungal, anti‐tuberculosis, antiprotozoal) and in silico molecular docking of biphenyl ether based Schiff's base analogues. ABSTRACT In order to investigate their possible biological activity, a number of new Schiff base compounds based on diaryl ether, specifically 2‐(substituted‐arylamino)‐N′‐(3 ...
Navin B. Patel, Deepti S. Ghaisas, Vatsal M. Patel, Faiyazalam M. Shaikh, Mohit Agrawal, Mohd Imran, Gildardo Rivera, Hetal I. Soni   +7 more
wiley   +1 more source

Effect of haemoglobin on promastigote growth.

, 2017
Promastigotes were cultured in triplicate in three media differing in haemoglobin content; M1 (0.0099 g/L), M2 (0.495 g/L) and M3 (0.99 g/L). These media were accompanied by a negative control medium containing no haemoglobin (M0).
Joel Barratt (697223), Alexa Kaufer (3637477), Douglas Craig (3637471), Bryce Peters (3637474), Damien Stark (697228), Rogan Lee (697225), Tamalee Roberts (697222), Andrea Lawrence (3637483), John Ellis (697227), Gary McAuliffe (3637480)   +9 more
core   +1 more source

Effective Tetradentate Compound Complexes against Leishmania spp. that Act on Critical Enzymatic Pathways of These Parasites

Molecules, 2018
The spectrum and efficacy of available antileishmanial drugs is limited. In the present work we evaluated in vitro the antiproliferative activity of 11 compounds based on tetradentate polyamines compounds against three Leishmania species (L. braziliensis,
Kristína Urbanová, Inmaculada Ramírez-Macías, Rubén Martín-Escolano, María José Rosales, Olaf Cussó, Joan Serrano, Anna Company, Manuel Sánchez-Moreno, Miquel Costas, Xavi Ribas, Clotilde Marín   +10 more
doaj   +1 more source