Experimental induction of paromomycin resistance in antimony-resistant strains of L. donovani : outcome dependent on in vitro selection protocol [PDF]
, 2012 Paromomycin (PMM) has recently been introduced for treatment of visceral leishmaniasis in India. Although no clinical resistance has yet been reported, proactive vigilance should be warranted. The present in vitro study compared the outcome and stability
Maes, L. +55 more
core +5 more sources
Complete developmental cycle of Leishmania mexicana in axenic culture [PDF]
, 1994 A complete developmental sequence of Leishmania mexicana has been produced in axenic culture for the first time. This was achieved by manipulation of media, pH and temperature conditions over a period of 16 days.
Bates, P A
core +4 more sources
Isolation of Leishmania promastigote flagella [PDF]
, 2020 Eukaryotic flagella are conserved multifunctional organelles with roles in motility, intercellular interactions and signal transduction. Leishmania possess a single flagellum at all stages of their life cycle.
Eva Gluenz +7 more
core +1 more source
Probing 5-Nitroimidazole-Triazole Hybrids as Potential Anti-Kinetoplastid Agents: Synthesis and In Vitro Efficacy. [PDF]
ChemMedChemA series of 5‐nitroimidazole‐1,2,3‐triazole hybrids was synthesised and evaluated for antitrypanosomatid activity to assess their potential as treatments against leishmaniasis and trypanosomiasis. No notable in vitro activity against Leishmania was detected.
Ferreira L +4 more
europepmc +2 more sources
Comparative study of the ability of Leishmania mexicana promastigotes and amastigotes to alter macrophage signalling and functions [PDF]
, 2010 Leishmania alternates between two morphologically different stages: promastigotes and amastigotes. While the majority of reports focused on how the promastigote form can alter macrophage signalling and function, fewer reports investigated signalling ...
Hassani, K. +9 more
core +1 more source
The role of promastigote secretory gel in the origin and transmission of the infective stage of Leishmania mexicana by the sandfly Lutzomyia longipalpis [PDF]
, 2002 Transmission of leishmaniasis is effected by a specific developmental stage, the metacyclic promastigote. The precursors of metacyclic promastigotes were a distinct subpopulation of parasites, identified for the first time as a new stage in the life ...
Rogers, M E, Bates, P A, Chance, M L
core +5 more sources
αAu2S nanoparticles: Fungal-mediated synthesis, structural characterization and bioassay
Green Chemistry Letters and Reviews, 2022 Luminescent nanoparticles synthesized via bio-based protocols that generate nanoparticles having different chemical compositions along with other functionalities (size and morphology) have received huge attention.
Asad Syed +7 more
doaj +1 more source
Evaluation of the Efficacy of Sodium Chloride Nanoparticles on the Vitality of Leishmania Major (in vitro) [PDF]
Archives of Razi Institute, 2023 Leishmaniasis is one of the most important zoonotic diseases transmitted to humans by sand flies (Phlebotomus spp). Leishmania major promastigote causes Cutaneous Leishmaniasis in humans.
I Abbas Marhoon, M Majid Al-Musawi
doaj +1 more source
Chitosan-Based Nanomaterials as Valuable Sources of Anti-Leishmanial Agents: A Systematic Review
Nanomaterials, 2021 Background: The current chemotherapy agents against various forms of leishmaniasis have some problems and side effects, including high toxicity, high cost, and the emergence of resistant strains. Here, we aimed to review the preclinical studies (in vitro
Hamdan I. AlMohammed +6 more
doaj +1 more source
In vitro and in vivo effects of Astragalus ecbatanus extract against cutaneous leishmaniasis [PDF]
Archives of Razi InstituteDue to the unique properties of Astragalus in the treatment of diseases and strengthening the immune system, for the first time, this study tried to study the in vitro and in vivo leishmanicidal effects of chloroform extract of A.
Seyedeh Negar Taheri +4 more
doaj +1 more source