Results 31 to 40 of about 1,816,357 (289)

Multilineage hematopoietic recovery with concomitant antitumor effects using low dose Interleukin-12 in myelosuppressed tumor-bearing mice [PDF]

, 2008
Background Interleukin-12 (IL-12) is a cytokine well known for its role in immunity. A lesser known function of IL-12 is its role in hematopoiesis. The promising data obtained in the preclinical models of antitumor immunotherapy raised hope that IL-12 ...
Lena A Basile, Timothy K Gallaher, Darryl Shibata, Joseph D Miller, Dan Douer, RG Bociek, V Zagonel, L Vahdat, AA Awedan, CH Wang, S Negoro, RM Lemoli, R Neta, DC Fisher, S Veltri, J Neidhart, MN Beck, R Kurzrock, GD Demetri, VS Gallicchio, DH Lynch, P Tiberghien, KM Zsebo, MA Mouthon, K Shibuya, BD Curti, IK McNiece, RL Basser, MP Colombo, MJ Brunda, MJ Smyth, J Gillary Segak, MA O'Donnell, AH Mandpe, JP Leonard, G Bellone, R Neta, SE Jacobsen, RE Ploemacher, JD Jackson, T Chen, C Plasencia, U Steidl, JK Lee, G Fulop, P Serafini, W Hocking, N Omura, MY Mapara, RL DeGowin, CJ Kovacs, G Bellone, JP Zou, H Mouri, M Ida, K Skomorovski, TI Pestina, A Schwarz, A Schwarz, SM Meeran, BD Car, BD Car, VM Eng, RF Little, S Demaria, A Yasuda, H Quentmeier, U.S. Food and Drug Administration, M Henke, B Leyland-Jones   +69 more
core   +2 more sources

Cytokine Secretion in Macrophages: SNAREs, Rabs and Membrane Trafficking.

Frontiers in Immunology, 2014
Macrophages have the capacity to rapidly secrete a wide range of inflammatory mediators that influence the development and extent of an inflammatory response.
Rachael Zoe Murray, Jennifer L Stow
doaj   +1 more source

Effect of macrophages in semen on sperm quality

Reproductive Biology and Endocrinology, 2021
Background This was a cross-sectional study in China which analyzed the levels of macrophages (Mφ) in semen and evaluated the influence of Mφ levels in semen on sperm quality. Methods The subjects involves 78 males, 25- to 35-year old.
Gangxin Chen, Beihong Zheng
doaj   +1 more source

IL-12 and Viral Infections

Cytokine & Growth Factor Reviews, 1998
Interleukin-12 activates natural killer cells and promotes the differentiation of Th1 CD4+ cells; it is a critical factor in viral immunity. IL-12 is secreted by antigen presenting cells including dendritic cells, macrophages and astrocytes, both in tissues and in secondary lymphoid organs.
Komastu, Takashi, Ireland, Derek D.C, Reiss, Carol Shoshkes   +2 more
openaire   +2 more sources

Role of Costimulation in the Induction of the IL-12/IL-12 Receptor Pathway and the Development of Autoimmunity [PDF]

The Journal of Immunology, 2000
Abstract Costimulation mediated by the interactions of the B7 Ags (CD80/CD86) on APC with CD28 on the responding T cell regulates the magnitude of the immune response and may influence Th1/Th2 development. The IL-12Rβ2 subunit plays a critical role in maintaining IL-12 responsiveness and controlling Th1 lineage commitment.
J T, Chang, B M, Segal, E M, Shevach
openaire   +2 more sources

IL-12 Family Cytokines: General Characteristics, Pathogenic Microorganisms, Receptors, and Signalling Pathways [PDF]

, 2016
Among a wide range of cytokines, the Interleukin 12 (IL-12) family has its unique structural, functional, and immunological characteristics that have made this family as important immunological playmakers. Because of the importance of IL-12 heterodimeric
Behzadi, Elham, Behzadi, Payam, Ranjbar, Reza   +2 more
core   +1 more source

Eicosane, pentadecane and palmitic acid: The effects in in vitro wound healing studies

Asian Pacific Journal of Tropical Biomedicine, 2018
Objective: To examine the wound healing properties of eicosane, pentadecane and palmitic acid by evaluating in term of anti-microbial, anti-inflammatory, proliferation, migration and collagen synthesis.
Xin Qi Chuah, Patrick Nwabueze Okechukwu, Farahnaz Amini, Swee Sen Teo   +3 more
doaj   +1 more source

IL-12 receptor regulation in IL-12-deficient BALB / c and C57BL / 6 mice [PDF]

European Journal of Immunology, 2000
Immunization with protein antigen in complete Freund's adjuvant (CFA) induces Th1 cells in BALB/c and C57BL/6 (B6) mice. Pretreatment with the same protein in soluble form induces Th2 cells in BALB/c but not in B6 mice and inhibits Th1 cell development in both.
F, Galbiati, L, Rogge, L, Adorini
openaire   +2 more sources

Immunogenicity evaluation of a DNA vaccine expressing the hepatitis C virus non-structural protein 2 gene in C57BL/6 Mice [PDF]

, 2013
Backgrounds: Most of the hepatitis C virus (HCV) infections elicit poor immune responses and 75% to 85% of cases become chronic; therefore, the development of an effective vaccine against HCV is of paramount importance.
Behnampour, N., Ghaemi, A., Gorzin, A.A., Gorzin, Z., Irani, S., Tabarraei, A.   +5 more
core   +2 more sources

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source