Results 51 to 60 of about 1,816,357 (289)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine +14 more
wiley +1 more source
Targeting IL-23: Insights into the pathogenesis and the treatment of psoriasis
Indian Journal of Dermatology, 2010 Therapeutic experience strongly supports the use of TNF antagonists as important modalities in the treatment of psoriatic arthritis and plaque psoriasis.
Lima Hermenio, Kimball Alexandra
doaj
ChildrenBackground: The rising rates of gallstones and cholecystectomy in pediatric populations underscore the increasing concern regarding chronic cholecystitis.
Kaiva Zīle Zariņa +2 more
doaj +1 more source
Memory-Like NK Cells: Remembering a Previous Activation by Cytokines and NK Cell Receptors
Frontiers in Immunology, 2018 Natural Killer (NK) cells are cytotoxic innate lymphoid cells serving at the front line against infection and cancer. In inflammatory microenvironments, multiple soluble and contact-dependent signals modulate NK cell responsiveness.
Jens H. W. Pahl +3 more
doaj +1 more source
Novel function for the p38-MK2 signaling pathway in circulating CD1c1 (BDCA-11) myeloid dendritic cells from healthy donors and advanced cancer patients; inhibition of p38 enhances IL-12 whilst suppressing IL-10 [PDF]
, 2013 There is growing interest in myeloid (my) dendritic cells (DC) as an alternative to monocyte-derived DC (moDC) for immunotherapy. However, in contrast to moDC, little is known regarding the effect of malignancy on the function, abundance or use of ...
Collins, Mary +6 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács +8 more
wiley +1 more source
, 2020 As its first identified member, Interleukin-12 (IL-12) named a whole family of cytokines. In response to pathogens, the heterodimeric protein, consisting of the two subunits p35 and p40, is secreted by phagocytic cells. Binding of IL-12 to the IL-12 receptor (IL-12R) on T and natural killer (NK) cells leads to signaling via signal transducer and ...
Ullrich, Karen Anne-Marie +5 more
openaire +2 more sources
Genetic heterogeneity in the toxicity to systemic adenoviral gene transfer of interleukin-12 [PDF]
, 2001 Despite the efficacy of IL-12 in cancer experimental models, clinical trials with systemic recombinant IL-12 showed unacceptable toxicity related to endogenous IFNgamma production.
Mazzolini, G. (Guillermo) +8 more
core +1 more source
Human_Leishmaniasis@cytokines.bahia.br
Brazilian Journal of Medical and Biological Research, 1998 The cell-mediated immune response is critical in the resistance to and recovery from leishmaniasis. Cytokines are central elements in mounting an immune response and have received a great deal of attention in both human and experimental leishmaniasis ...
M. Barral-Netto +3 more
doaj +1 more source
Effects of pulsing procedure of interleukin-12 in combination with interleukin-2 on the activation of peripheral blood lymphocytes derived from patients with hepatocellular carcinoma. [PDF]
, 2003 In patients with hepatocellular carcinoma (HCC), natural killer (NK) cell activity decreases significantly, and the reduced activity may be associated with the progression of HCC.
Nishimura, Mamoru +7 more
core +1 more source