Plasma interleukin-12 levels as a potential biomarker of fatigue and quality of life in patients with primary immune thrombocytopenia [PDF]
Blood ResearchBackground Fatigue significantly affects health-related quality of life (HRQoL) in patients with immune thrombocytopenia (ITP). However, the interplay between fatigue and cytokines in ITP remains poorly understood.
Sarthak Wadhera +12 more
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Atomic Pt-Layer-Coated Au Peroxidase Nanozymes with Enhanced Activity for Ultrasensitive Colorimetric Immunoassay of Interleukin-12 [PDF]
BiosensorsInterleukin-12 (IL-12), a crucial biomarker for immune and inflammatory responses, plays a pivotal role in diagnosing and managing diverse pathological conditions.
Han Zhang +6 more
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Tumor-specific AAV delivery of interleukin-12 enhances antitumor immunity and safety in ovarian cancer xenograft mouse model [PDF]
Molecular Therapy: OncologyInterleukin-12 (IL-12) is a promising pro-inflammatory cytokine for cancer immunotherapy, but its toxicity and short half-life in serum limit its clinical application.
Chuyuan Chen +6 more
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Oncolytic cytomegaloviruses expressing EGFR-retargeted fusogenic glycoprotein complex and drug-controllable interleukin 12 [PDF]
Cell Reports MedicineSummary: Cytomegalovirus (CMV) infects a wide range of cell types, including tumor-associated myeloid cells and glioma cells. Clinical observations suggest a potential link between long-term glioblastoma survival and CMV reactivation.
Haifei Jiang +5 more
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Interleukin‐12 sustained release system promotes hematopoietic recovery after radiation injury [PDF]
MedCommThe continuous production of mature blood cell lineages is maintained by hematopoietic stem cells but they are highly susceptible to damage by ionizing radiation (IR) that induces death.
Chuanchuan Lin +16 more
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Научно-практическая ревматология, 2022 Among the pathophysiological mechanisms of immune-mediated inflammatory diseases (IMIDs), specific attention has been paid to the abnormal activation of Th17 type immune response related to the dysregulated synthesis of cytokines forming the interleukin (
E. L. Nasonov +3 more
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Biochemical, Molecular and Histopathological changes of rheumatoid arthritis induced experimentally in rats [PDF]
Benha Veterinary Medical Journal, 2023 Complete Freund's adjuvant (CFA) is a mixture of dessicated mycobacterium in mannide monooleate and paraffin oil that causes tissue death, lesions, and inflammation.
Nihal Amer +3 more
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BMC Medical Genetics, 2020 Background Intervertebral disc degeneration (IVDD) is an age-related degenerative disease, presenting with low back pain or radicular pain. The inflammatory changes would occur in discs in the process of IVDD.
Sara Hanaei +6 more
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Interleukin-12 Message in a Bottle
Clinical Cancer Research, 2020 Abstract IL12 is a very potent cancer immunotherapy agent, but is difficult to harness safely if given systemically. Local gene transfer aims to confine the effects of IL12 to malignant tissues, thus avoiding toxicity. Lipid-nanoparticle mRNA achieves IL12 expression and efficacy in mouse models, opening the way to an ongoing trial.
Assunta Cirella +3 more
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Iranian Journal of Parasitology, 2020 Background: The possible risk factor of Toxoplasma infection and its possible correlation with Interleukin-12 (IL-12) and Interleukin-23 (IL-23) in breast cancer patients was investigated. Methods: Overall, 190 female patients referred to the Oncology
Maha Mustafa ASSIM, Entsar Jabbar SAHEB
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