Plasma interleukin-12 levels as a potential biomarker of fatigue and quality of life in patients with primary immune thrombocytopenia [PDF]
Blood ResearchBackground Fatigue significantly affects health-related quality of life (HRQoL) in patients with immune thrombocytopenia (ITP). However, the interplay between fatigue and cytokines in ITP remains poorly understood.
Sarthak Wadhera +12 more
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Monocyte-regulated interleukin 12 production drives clearance of Staphylococcus aureus. [PDF]
PLoS PathogensStaphylococcus aureus is a versatile bacterium responsible for conditions ranging from mild skin and soft-tissue infections to serious disorders such as pneumonia and sepsis.
Adeline Peignier +3 more
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Atomic Pt-Layer-Coated Au Peroxidase Nanozymes with Enhanced Activity for Ultrasensitive Colorimetric Immunoassay of Interleukin-12 [PDF]
BiosensorsInterleukin-12 (IL-12), a crucial biomarker for immune and inflammatory responses, plays a pivotal role in diagnosing and managing diverse pathological conditions.
Han Zhang +6 more
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Tumor-specific AAV delivery of interleukin-12 enhances antitumor immunity and safety in ovarian cancer xenograft mouse model [PDF]
Molecular Therapy: OncologyInterleukin-12 (IL-12) is a promising pro-inflammatory cytokine for cancer immunotherapy, but its toxicity and short half-life in serum limit its clinical application.
Chuyuan Chen +6 more
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Oncolytic cytomegaloviruses expressing EGFR-retargeted fusogenic glycoprotein complex and drug-controllable interleukin 12 [PDF]
Cell Reports MedicineSummary: Cytomegalovirus (CMV) infects a wide range of cell types, including tumor-associated myeloid cells and glioma cells. Clinical observations suggest a potential link between long-term glioblastoma survival and CMV reactivation.
Haifei Jiang +5 more
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Научно-практическая ревматология, 2022 Among the pathophysiological mechanisms of immune-mediated inflammatory diseases (IMIDs), specific attention has been paid to the abnormal activation of Th17 type immune response related to the dysregulated synthesis of cytokines forming the interleukin (
E. L. Nasonov +3 more
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Biochemical, Molecular and Histopathological changes of rheumatoid arthritis induced experimentally in rats [PDF]
Benha Veterinary Medical Journal, 2023 Complete Freund's adjuvant (CFA) is a mixture of dessicated mycobacterium in mannide monooleate and paraffin oil that causes tissue death, lesions, and inflammation.
Nihal Amer +3 more
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BMC Medical Genetics, 2020 Background Intervertebral disc degeneration (IVDD) is an age-related degenerative disease, presenting with low back pain or radicular pain. The inflammatory changes would occur in discs in the process of IVDD.
Sara Hanaei +6 more
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Iranian Journal of Parasitology, 2020 Background: The possible risk factor of Toxoplasma infection and its possible correlation with Interleukin-12 (IL-12) and Interleukin-23 (IL-23) in breast cancer patients was investigated. Methods: Overall, 190 female patients referred to the Oncology
Maha Mustafa ASSIM, Entsar Jabbar SAHEB
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Factors Associated With In Vitro Interferon-gamma Production in Tuberculosis
Journal of the Formosan Medical Association, 2011 Macrophage activation assisted by interferon-gamma (IFN-γ) is a primary mechanism by which Mycobacterium tuberculosis is killed, but IFN-γ (production is inhibited in tuberculosis (TB) patients. The production of IFN-γ is influenced by many factors, such
Chung-Chieh Yu +5 more
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