Results 1 to 10 of about 668,687 (209)

Plasma interleukin-12 levels as a potential biomarker of fatigue and quality of life in patients with primary immune thrombocytopenia [PDF]

Blood Research
Background Fatigue significantly affects health-related quality of life (HRQoL) in patients with immune thrombocytopenia (ITP). However, the interplay between fatigue and cytokines in ITP remains poorly understood.
Sarthak Wadhera, Arihant Jain, Aarushi Sahni, Rudra Narayan Swain, Charanpreet Singh, Aditya Jandial, Ritu Aggarwal, Rekha Hans, Gaurav Prakash, Alka Khadwal, Sandeep Grover, Reena Das, Pankaj Malhotra   +12 more
doaj   +2 more sources

Atomic Pt-Layer-Coated Au Peroxidase Nanozymes with Enhanced Activity for Ultrasensitive Colorimetric Immunoassay of Interleukin-12 [PDF]

Biosensors
Interleukin-12 (IL-12), a crucial biomarker for immune and inflammatory responses, plays a pivotal role in diagnosing and managing diverse pathological conditions.
Han Zhang, Xiang Peng, Hao Song, Yongfeng Tan, Jianglian Xu, Qunfang Li, Zhuangqiang Gao   +6 more
doaj   +2 more sources

Tumor-specific AAV delivery of interleukin-12 enhances antitumor immunity and safety in ovarian cancer xenograft mouse model [PDF]

Molecular Therapy: Oncology
Interleukin-12 (IL-12) is a promising pro-inflammatory cytokine for cancer immunotherapy, but its toxicity and short half-life in serum limit its clinical application.
Chuyuan Chen, Yongji Jiang, Chuan Feng, Qingyun Zhou, Xingrong Luo, Lili Cai, Lei Zhao   +6 more
doaj   +2 more sources

Association and Interaction Effects of Interleukin-12 Related Genes and Physical Activity on Cognitive Aging in Old Adults in the Taiwanese Population [PDF]

Frontiers in Neurology, 2019
Evidence suggests that the neuro-inflammation mechanisms associated with interleukin-12 (IL-12) may be linked to Alzheimer's diseases and cognitive aging.
Eugene Lin, Eugene Lin, Eugene Lin, Po-Hsiu Kuo, Yu-Li Liu, Albert C. Yang, Albert C. Yang, Shih-Jen Tsai, Shih-Jen Tsai   +8 more
doaj   +2 more sources

Oncolytic cytomegaloviruses expressing EGFR-retargeted fusogenic glycoprotein complex and drug-controllable interleukin 12 [PDF]

Cell Reports Medicine
Summary: Cytomegalovirus (CMV) infects a wide range of cell types, including tumor-associated myeloid cells and glioma cells. Clinical observations suggest a potential link between long-term glioblastoma survival and CMV reactivation.
Haifei Jiang, Rebecca Nace, Coryn Ferguson, Lianwen Zhang, Kah Whye Peng, Stephen J. Russell   +5 more
doaj   +2 more sources

Interleukin‐12 sustained release system promotes hematopoietic recovery after radiation injury [PDF]

MedComm
The continuous production of mature blood cell lineages is maintained by hematopoietic stem cells but they are highly susceptible to damage by ionizing radiation (IR) that induces death.
Chuanchuan Lin, Yang Xiang, Yangyang Zhang, Zhenxing Yang, Nanxi Chen, Weiwei Zhang, Lanyue Hu, Jianxin Chen, Ya Luo, Xueying Wang, Yanni Xiao, Qing Zhang, Xi Ran, Li Chen, Jigang Dai, Zhongjun Li, Qian Ran   +16 more
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Prospects for the use of monoclonal antibodies to interleukin 23 Gusеlkumab in psoriatic arthritis: New data

Научно-практическая ревматология, 2022
Among the pathophysiological mechanisms of immune-mediated inflammatory diseases (IMIDs), specific attention has been paid to the abnormal activation of Th17 type immune response related to the dysregulated synthesis of cytokines forming the interleukin (
E. L. Nasonov, T. V. Korotaeva, S. Rodolfi, C. F. Selmi   +3 more
doaj   +1 more source

Phase II Trial of IL-12 Plasmid Transfection and PD-1 Blockade in Immunologically Quiescent Melanoma. [PDF]

, 2020
PurposeTumors with low frequencies of checkpoint positive tumor-infiltrating lymphocytes (cpTIL) have a low likelihood of response to PD-1 blockade.
Algazi, Alain P, Andtbacka, Robert HI, Arlauckas, Sean P, Ballesteros-Merino, Carmen, Bannavong, Donna, Bhatia, Shailender, Bifulco, Carlos, Browning, Erica, Canton, David A, Daud, Adil I, Fong, Lawrence, Fox, Bernard A, Francisco, Murray, Gargosky, Sharron, Garris, Christopher, Hermiz, Reneta, Le, Mai, Levine, Lauren P, Oglesby, Arielle, Pierce, Robert, Pittet, Mikael J, Rosenblum, Michael D, Tsai, Katy K, Twitty, Christopher G   +23 more
core   +2 more sources

Association of interleukin 2, interleukin 12, and interferon-γ with intervertebral disc degeneration in Iranian population

BMC Medical Genetics, 2020
Background Intervertebral disc degeneration (IVDD) is an age-related degenerative disease, presenting with low back pain or radicular pain. The inflammatory changes would occur in discs in the process of IVDD.
Sara Hanaei, Sina Abdollahzade, Maryam Sadr, Mohammad Hossein Mirbolouk, Ehsan Fattahi, Alireza Khoshnevisan, Nima Rezaei   +6 more
doaj   +1 more source

Serum Levels of Il-12 and Il-23 in Breast Cancer Patients Infected with Toxoplasma gondii: A Case-Control Study

Iranian Journal of Parasitology, 2020
Background: The possible risk factor of Toxoplasma infection and its possible correlation with Interleukin-12 (IL-12) and Interleukin-23 (IL-23) in breast cancer patients was investigated. Methods: Overall, 190 female patients referred to the Oncology
Maha Mustafa ASSIM, Entsar Jabbar SAHEB
doaj   +1 more source