The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP-lpr/lpr mice [PDF]
, 1996 MRL/MP-lpr/lpr (MRL/lpr) mice develop a spontaneous autoimmune disease. Serum from these mice contained significantly higher concentrations of nitrite/nitrate than serum from age-matched control MRL/MP-+/+ (MRL/+), BALB/c or CBA/6J mice.
Liew, F.Y. +4 more
core +9 more sources
Evaluation of Salivary Interleukin 2 (IL-2) and Interleukin 12(IL-12) in Recurrent Aphthous Stomatitis [PDF]
Ibn Al-Haitham Journal for Pure and Applied SciencesRecurrent aphthous stomatitis (RAS) is a common kind of excruciating mouth mucosal disease. Despite their high prevalence, etiopathogenesis remains unclear.
Sura Farhan Saeed +1 more
doaj +2 more sources
Differential regulation of interleukin-17 and interferon-y production in inflammatory bowel disease [PDF]
, 2010 PhDBackground and Aims. Interleukin (IL)-17 is now known to be involved in a number of chronic inflammatory disorders. However, the mechanisms regulating its production in inflammatory bowel disease (IBD) are still unclear. Methods.
Rovedatti, Laura
core +4 more sources
Impact of angiotensin converting enzyme inhibition on post- coronary artery bypass interleukin 6 release [PDF]
, 2002 Background: Angiotensin 1 converting enzyme (ACE) inhibitors reduce morbidity and mortality after coronary artery bypass graft surgery (CABG). This benefit may result from an anti- inflammatory action.
Humphries, S.E. +5 more
core +8 more sources
Factors Associated With In Vitro Interferon-gamma Production in Tuberculosis
Journal of the Formosan Medical Association, 2011 Macrophage activation assisted by interferon-gamma (IFN-γ) is a primary mechanism by which Mycobacterium tuberculosis is killed, but IFN-γ (production is inhibited in tuberculosis (TB) patients. The production of IFN-γ is influenced by many factors, such
Chung-Chieh Yu +5 more
doaj +1 more source
Peripheral Helper Lymphocytes Produce Interleukin 12 in Cancer Patients
Clinical Medicine Insights: Oncology, 2013 The aim of the study was to seek evidence for the production of IL-12 by CD4 + T lymphocytes in in vitro and ex vivo trials. We performed in vitro trials with spleen cells from mice subjected to carcinogenesis, as well as ex vivo trials with cells ...
Márcia A. Michelin +3 more
doaj +2 more sources
The Role of Interleukin 12 in Iraqi Patients with Psoriasis
مجلة علوم ذي قار, 2022 Psoriasis is a chronic skin condition with immune-mediated inflammatory etiology. Many studies have indicated that Interleukin-12 (IL-12) plays an essential role in the severity of psoriasis.So to elucidate IL-12 role in regulating psoriasis promotion ...
Emad A. Abbas, Hind M Mousa
doaj +1 more source
Regulation of NK cell development and function by cytokines
Frontiers in Immunology, 2013 Natural Killer (NK) cells are innate lymphocytes with an important role in the early defense against intracellular pathogens and against tumors. Like other immune cells, almost every aspects of their biology are regulated by cytokines.
Antoine eMarçais +5 more
doaj +1 more source
Interleukin-12 and photocarcinogenesis [PDF]
Toxicology and Applied Pharmacology, 2007 UV radiation induces immunosuppression and inflammatory responses, as well as oxidative stress and DNA damage, in skin cells and these various effects have been implicated in melanoma and nonmelanoma skin cancers, i.e., photocarcinogenesis. The cytokine interleukin (IL)-12 has been shown to possess potent antitumor activity in a wide variety of murine ...
openaire +2 more sources
, 2003 Interleukin-18 (IL-18), a recently described member of the IL-1 cytokine superfamily, is now recognized as an important regulator of innate and acquired immune responses.
McInnes, I.B. +2 more
core +1 more source