Results 11 to 20 of about 645,790 (259)
Peripheral Helper Lymphocytes Produce Interleukin 12 in Cancer Patients
Clinical Medicine Insights: Oncology, 2013 The aim of the study was to seek evidence for the production of IL-12 by CD4 + T lymphocytes in in vitro and ex vivo trials. We performed in vitro trials with spleen cells from mice subjected to carcinogenesis, as well as ex vivo trials with cells ...
Márcia A. Michelin +3 more
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The Role of Interleukin 12 in Iraqi Patients with Psoriasis
مجلة علوم ذي قار, 2022 Psoriasis is a chronic skin condition with immune-mediated inflammatory etiology. Many studies have indicated that Interleukin-12 (IL-12) plays an essential role in the severity of psoriasis.So to elucidate IL-12 role in regulating psoriasis promotion ...
Emad A. Abbas, Hind M Mousa
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Factors Associated With In Vitro Interferon-gamma Production in Tuberculosis
Journal of the Formosan Medical Association, 2011 Macrophage activation assisted by interferon-gamma (IFN-γ) is a primary mechanism by which Mycobacterium tuberculosis is killed, but IFN-γ (production is inhibited in tuberculosis (TB) patients. The production of IFN-γ is influenced by many factors, such
Chung-Chieh Yu +5 more
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Regulation of NK cell development and function by cytokines
Frontiers in Immunology, 2013 Natural Killer (NK) cells are innate lymphocytes with an important role in the early defense against intracellular pathogens and against tumors. Like other immune cells, almost every aspects of their biology are regulated by cytokines.
Antoine eMarçais +5 more
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Interleukin-12 and photocarcinogenesis [PDF]
Toxicology and Applied Pharmacology, 2007 UV radiation induces immunosuppression and inflammatory responses, as well as oxidative stress and DNA damage, in skin cells and these various effects have been implicated in melanoma and nonmelanoma skin cancers, i.e., photocarcinogenesis. The cytokine interleukin (IL)-12 has been shown to possess potent antitumor activity in a wide variety of murine ...
openaire +2 more sources
Journal of Venomous Animals and Toxins including Tropical Diseases, 2010 Hepatitis C virus (HCV) patients commonly have low platelet counts; however, the exact role of HCV infection in thrombocytopenia is unknown. This work aimed to study the serum levels of interleukins (IL) 10 and 12 in patients with mild and moderate ...
N Abdallah +3 more
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Localized Interleukin-12 for Cancer Immunotherapy
Frontiers in Immunology, 2020 Interleukin-12 (IL-12) is a potent, pro-inflammatory type 1 cytokine that has long been studied as a potential immunotherapy for cancer. Unfortunately, IL-12's remarkable antitumor efficacy in preclinical models has yet to be replicated in humans.
Khue G. Nguyen +6 more
doaj +1 more source
Interleukin-12 in infectious diseases [PDF]
Clinical Microbiology Reviews, 1997 Interleukin-12 (IL-12) is a potent immunoregulatory cytokine that is crucially involved in a wide range of infectious diseases. In several experimental models of bacterial, parasitic, viral, and fungal infection, endogenous IL-12 is required for early control of infection and for generation and perhaps maintenance of acquired protective immunity ...
ROMANI, Luigina +2 more
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Molecular Therapy: Oncolytics, 2023 Oncolytic viruses are of significant clinical interest due to their ability to directly infect and kill tumors and enhance the anti-tumor immune response.
Soon-Oh Hong +15 more
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Significance of the determination of proinflammatory cytokines in the serum of polytraumatized patients with sepsis [PDF]
Vojnosanitetski Pregled, 2004 Severe sepsis and trauma complicated with multiple organ dysfunction syndrome (MODS) are among the leading causes of death in intensive therapy units with mortality rate exceeding 50%.
Šurbatović Maja +4 more
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