Results 1 to 10 of about 5,889 (114)

Prospects for the use of monoclonal antibodies to interleukin 23 Gusеlkumab in psoriatic arthritis: New data

Научно-практическая ревматология, 2022
Among the pathophysiological mechanisms of immune-mediated inflammatory diseases (IMIDs), specific attention has been paid to the abnormal activation of Th17 type immune response related to the dysregulated synthesis of cytokines forming the interleukin (
E. L. Nasonov, T. V. Korotaeva, S. Rodolfi, C. F. Selmi   +3 more
doaj   +1 more source

What We Learned about the Feasibility of Gene Electrotransfer for Vaccination on a Model of COVID-19 Vaccine

Pharmaceutics, 2023
DNA vaccination is one of the emerging approaches for a wide range of applications, including prophylactic vaccination against infectious diseases and therapeutic vaccination against cancer.
Urska Kamensek, Maja Cemazar, Simona Kranjc Brezar, Tanja Jesenko, Spela Kos, Katarina Znidar, Bostjan Markelc, Ziva Modic, Tilen Komel, Tim Gorse, Eva Rebersek, Helena Jakopic, Gregor Sersa   +12 more
doaj   +1 more source

Treatment of skin tumors with intratumoral interleukin 12 gene electrotransfer in the head and neck region: a first-in-human clinical trial protocol

Radiology and Oncology, 2022
Immune therapies are currently under intensive investigation providing in many cases excellent responses in different tumors. Other possible approach for immunotherapy is a targeted intratumoral delivery of interleukin 12 (IL-12), a cytokine with anti ...
Groselj Ales, Bosnjak Masa, Jesenko Tanja, Cemazar Maja, Markelc Bostjan, Strojan Primoz, Sersa Gregor   +6 more
doaj   +1 more source

Intratumoral injection of IL-12-encoding mRNA targeted to CSFR1 and PD-L1 exerts potent anti-tumor effects without substantial systemic exposure

Molecular Therapy: Nucleic Acids, 2023
IL-12 is a potent cytokine for cancer immunotherapy. However, its systemic delivery as a recombinant protein has shown unacceptable toxicity in the clinic.
Claudia Augusta Di Trani, Assunta Cirella, Leire Arrizabalaga, Maite Alvarez, Ángela Bella, Myriam Fernandez-Sendin, Joan Salvador Russo-Cabrera, Celia Gomar, Nuria Ardaiz, Alvaro Teijeira, Elixabet Bolaños, José González-Gomariz, Itziar Otano, Fernando Aranda, Belén Palencia, Aina Segués, Shuyu Huang, Sander M.J. van Duijnhoven, Andrea van Elsas, Ignacio Melero, Pedro Berraondo   +20 more
doaj   +1 more source

Intracavitary adoptive transfer of IL-12 mRNA-engineered tumor-specific CD8+ T cells eradicates peritoneal metastases in mouse models

OncoImmunology, 2023
Previous studies have shown that local delivery of tumor antigen-specific CD8+ T lymphocytes engineered to transiently express single-chain IL-12 mRNA is highly efficacious.
Claudia Augusta Di Trani, Assunta Cirella, Leire Arrizabalaga, Ángela Bella, Myriam Fernandez-Sendin, Joan Salvador Russo-Cabrera, Celia Gomar, Irene Olivera, Elizabeth Bolaños, José González-Gomariz, Maite Álvarez, Iñaki Etxeberria, Belen Palencia, Álvaro Teijeira, Ignacio Melero, Pedro Berraondo, Fernando Aranda   +16 more
doaj   +1 more source

Administration of fusion cytokines induces tumor regression and systemic antitumor immunity

MedComm, 2021
It is difficult to improve the curative effects of cancer immunotherapy on solid tumors. Cytokines, as powerful immune regulators, show potential in activating host antitumor immunity.
Jinyu Zhang, Xuan Zhao
doaj   +1 more source

Non-Clinical In Vitro Evaluation of Antibiotic Resistance Gene-Free Plasmids Encoding Human or Murine IL-12 Intended for First-in-Human Clinical Study

Pharmaceutics, 2021
Interleukin 12 (IL-12) is a key cytokine that mediates antitumor activity of immune cells. To fulfill its clinical potential, the development is focused on localized delivery systems, such as gene electrotransfer, which can provide localized delivery of ...
Spela Kos, Masa Bosnjak, Tanja Jesenko, Bostjan Markelc, Urska Kamensek, Katarina Znidar, Urska Matkovic, Andrej Rencelj, Gregor Sersa, Rosana Hudej, Aneja Tuljak, Matjaz Peterka, Maja Cemazar   +12 more
doaj   +1 more source

Interleukin-12 Message in a Bottle

Clinical Cancer Research, 2020
Abstract IL12 is a very potent cancer immunotherapy agent, but is difficult to harness safely if given systemically. Local gene transfer aims to confine the effects of IL12 to malignant tissues, thus avoiding toxicity. Lipid-nanoparticle mRNA achieves IL12 expression and efficacy in mouse models, opening the way to an ongoing trial.
Assunta Cirella, Pedro Berraondo, Claudia Augusta Di Trani, Ignacio Melero   +3 more
openaire   +3 more sources

Biochemical, Molecular and Histopathological changes of rheumatoid arthritis induced experimentally in rats [PDF]

Benha Veterinary Medical Journal, 2023
Complete Freund's adjuvant (CFA) is a mixture of dessicated mycobacterium in mannide monooleate and paraffin oil that causes tissue death, lesions, and inflammation.
Nihal Amer, Omnia abd elhamid, Hussein Abd Elmaksoud Ali, Naglaa Alhusseini   +3 more
doaj   +1 more source

Intravaginal Administration of Interleukin 12 during Genital Gonococcal Infection in Mice Induces Immunity to Heterologous Strains of Neisseria gonorrhoeae

mSphere, 2018
It has previously been shown that genital tract infection with Neisseria gonorrhoeae in mice does not induce a state of protective immunity against reinfection but instead suppresses the development of adaptive immune responses against N.
Yingru Liu, Julianny Perez, Laura A. Hammer, Heather C. Gallagher, Magdia De Jesus, Nejat K. Egilmez, Michael W. Russell   +6 more
doaj   +1 more source