Results 31 to 40 of about 986,782 (400)

Oral administration of Bifidobacterium breve promotes antitumor efficacy via dendritic cells-derived interleukin 12

OncoImmunology, 2021
Recent advances in immunotherapy, as a part of the multidisciplinary therapy, has gradually gained more attention. However, only a small proportion of patients who sensitive to the therapy could gain benefits.
Qingxiang Li, Yuke Li, Yifei Wang, Le Xu, Yuxing Guo, Yixiang Wang, Lin Wang, Chuanbin Guo   +7 more
doaj   +1 more source

Signaling via interleukin-4, receptor alpha chain is required for successful vaccination against schistosomiasis in BALB/c mice [PDF]

, 2001
Radiation-attenuated (RA) schistosome larvae are potent stimulators of innate immune responses at the skin site of exposure (pinna) that are likely to be important factors in the development of Th1-mediated protective immunity.
Anderson S., Anderson S., Anderson S., Artis D., Bancroft A. J., Bancroft A. J., Barner M., Belkaid Y., Brewer J. M., Brombacher F., Coulson P. S., D'Andrea A., de Andres B., Dean D. A., Delgado V., Donaldson D. D., Faquim-Mauro E. L., Galbiati F., Grunig G., Guler M. L., Hilton D. J., Hoffmann K. F., Hsieh C. S., James S. L., Jankovic D., Jankovic D., Jankovic D., King C. L., King C. L., Kopf M., Magram J., Mangold B. L., Matthews D. J., Mattner F., McKenzie G. J., Metwali A., Mohrs M., Mohrs M., Mountford A. P., Mountford A. P., Mountford A. P., Mountford A. P., Mountford A. P., Mountford A. P., Muchamuel T., Nelms K., Noben-Trauth N., Noben-Trauth N., Noben-Trauth N., O'Garra A., Pearce E. J., Reiner S. L., Scott P., Seder R. A., Sher A., Shibuya K., Smythies L. E., Smythies L. E., Street M., Szabo S. J., Urban J. F., Wilson R. A., Wynn T. A., Wynn T. A., Zurawski G.   +64 more
core   +2 more sources

Interleukin-12 and photocarcinogenesis [PDF]

Toxicology and Applied Pharmacology, 2007
UV radiation induces immunosuppression and inflammatory responses, as well as oxidative stress and DNA damage, in skin cells and these various effects have been implicated in melanoma and nonmelanoma skin cancers, i.e., photocarcinogenesis. The cytokine interleukin (IL)-12 has been shown to possess potent antitumor activity in a wide variety of murine ...
openaire   +2 more sources

Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial

Science Translational Medicine, 2019
An oral small molecule turns on the transcription of human interleukin-12, with biological effects in patients with recurrent high-grade gliomas. Think globally, treat locally The antitumor cytokine interleukin-12 cannot be used as a systemic treatment ...
E. Chiocca, John S. Yu, R. Lukas, Isaac H. Solomon, Keith L. Ligon, H. Nakashima, Daniel A. Triggs, David A. Reardon, P. Wen, Brittany M. Stopa, A. Naik, J. Rudnick, Jethro Hu, P. Kumthekar, B. Yamini, J. Buck, N. Demars, J. Barrett, A. Gelb, John Zhou, F. Lebel, Laurence Cooper   +21 more
semanticscholar   +1 more source

The immunobiology of the Interleukin-12 family: Room for discovery

Immunity, 2019
The discovery of interleukin (IL)-6 and its receptor subunits provided a foundation to understand the biology of a group of related cytokines: IL-12, IL-23, IL-27.
E. T. Wojno, C. Hunter, J. Stumhofer
semanticscholar   +1 more source

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation

Journal of Experimental Medicine, 1996
We investigated the possibility that T helper cells might enhance the stimulatory function of dendritic cells (DCs). We found that ligation of CD40 by CD40L triggers the production of extremely high levels of bioactive IL-12.
M. Celia, D. Scheidegger, Kathrin Palmer-Lehmann, P. Lane, A. Lanzavecchia, G. Alber   +5 more
semanticscholar   +1 more source

CpG and Interleukin-15 Synergize to Enhance IFN-γ Production by Activated CD8+ T Cells [PDF]

, 2012
Interleukin-15 (IL-15) regulates the development and maintenance of memory CD8+ T cells. Paradoxically, we previously reported that IL-15 could enhance CD8+ T-cell responses to IL-12, a proinflammatory cytokine required for optimal priming of effector ...
Cobb, Dustin, Guo, Siqi, Smeltz, Ronald B.   +2 more
core   +5 more sources

Regulation of NK cell development and function by cytokines

Frontiers in Immunology, 2013
Natural Killer (NK) cells are innate lymphocytes with an important role in the early defense against intracellular pathogens and against tumors. Like other immune cells, almost every aspects of their biology are regulated by cytokines.
Antoine eMarçais, Sébastien eViel, Morgan eGrau, Thomas eHenry, Jacqueline eMarvel, Thierry eWalzer   +5 more
doaj   +1 more source

Development of Interleukin-12-Producing Capacity throughout Childhood [PDF]

, 2002
Increasing evidence indicates that the capacity to induce protective Th1 immune responses is impaired in early childhood, an observation that can be partially attributed to deficiencies in antigen-presenting-cell function. Synthesis of interleukin 12 (IL-
Upham, John W., Lee, Peter T., Holt, Barbara J., Heaton, Tricia, Prescott, Susan L., Sharp, Mary J., Sly, Peter D., Holt, Patrick G.   +7 more
core   +1 more source

Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection. [PDF]

, 1994
Leishmania major are intramacrophage parasites whose eradication requires the induction of T helper 1 (Th1) effector cells capable of activating macrophages to a microbicidal state.
Locksley, RM, Reiner, SL, Stowring, L, Wang, ZE, Zheng, S   +4 more
core   +1 more source