Results 21 to 30 of about 7,945,801 (283)

Oral administration of Bifidobacterium breve promotes antitumor efficacy via dendritic cells-derived interleukin 12

OncoImmunology, 2021
Recent advances in immunotherapy, as a part of the multidisciplinary therapy, has gradually gained more attention. However, only a small proportion of patients who sensitive to the therapy could gain benefits.
Qingxiang Li, Yuke Li, Yifei Wang, Le Xu, Yuxing Guo, Yixiang Wang, Lin Wang, Chuanbin Guo   +7 more
doaj   +1 more source

Tumor cell-based vaccine contributes to local tumor irradiation by eliciting a tumor model-dependent systemic immune response

Frontiers in Immunology, 2022
Multimodal treatment approaches, such as radio-immunotherapy, necessitate regimen optimization and the investigation of the interactions of different modalities. The aim of this study was two-fold.
Tinkara Remic, Tinkara Remic, Gregor Sersa, Gregor Sersa, Kristina Levpuscek, Kristina Levpuscek, Ursa Lampreht Tratar, Ursa Lampreht Tratar, Katja Ursic Valentinuzzi, Katja Ursic Valentinuzzi, Andrej Cör, Andrej Cör, Urska Kamensek, Urska Kamensek   +13 more
doaj   +1 more source

Interleukin-18 [PDF]

, 2003
Interleukin-18 (IL-18), a recently described member of the IL-1 cytokine superfamily, is now recognized as an important regulator of innate and acquired immune responses.
McInnes, I.B., Robertson, S.E., Gracie, J.A.   +2 more
core   +1 more source

Association of interleukin 2, interleukin 12, and interferon-γ with intervertebral disc degeneration in Iranian population

BMC Medical Genetics, 2020
Background Intervertebral disc degeneration (IVDD) is an age-related degenerative disease, presenting with low back pain or radicular pain. The inflammatory changes would occur in discs in the process of IVDD.
Sara Hanaei, Sina Abdollahzade, Maryam Sadr, Mohammad Hossein Mirbolouk, Ehsan Fattahi, Alireza Khoshnevisan, Nima Rezaei   +6 more
doaj   +1 more source

Interleukin-12 and photocarcinogenesis [PDF]

Toxicology and Applied Pharmacology, 2007
UV radiation induces immunosuppression and inflammatory responses, as well as oxidative stress and DNA damage, in skin cells and these various effects have been implicated in melanoma and nonmelanoma skin cancers, i.e., photocarcinogenesis. The cytokine interleukin (IL)-12 has been shown to possess potent antitumor activity in a wide variety of murine ...
openaire   +2 more sources

Antitumor Potential of Extracellular Vesicles Released by Genetically Modified Murine Colon Carcinoma Cells With Overexpression of Interleukin-12 and shRNA for TGF-β1

Frontiers in Immunology, 2019
Recent developments demonstrate that tumor-derived extracellular vesicles (EVs) could become a highly effective tool for delivery of antitumor factors.
Joanna Rossowska, Natalia Anger, Katarzyna Wegierek, Agnieszka Szczygieł, Jagoda Mierzejewska, Magdalena Milczarek, Bożena Szermer-Olearnik, Elżbieta Pajtasz-Piasecka   +7 more
doaj   +1 more source

Morphological and Functional Characterization of IL-12Rβ2 Chain on Intestinal Epithelial Cells: Implications for Local and Systemic Immunoregulation

Frontiers in Immunology, 2018
Interaction between intestinal epithelial cells (IECs) and the underlying immune systems is critical for maintaining intestinal immune homeostasis and mounting appropriate immune responses.
Mari Regoli, Angela Man, Nadhezda Gicheva, Antonio Dumont, Kamal Ivory, Alessandra Pacini, Gabriele Morucci, Jacopo J. V. Branca, Monica Lucattelli, Ugo Santosuosso, Arjan Narbad, Massimo Gulisano, Eugenio Bertelli, Claudio Nicoletti   +13 more
doaj   +1 more source

Heterodimeric Fc-fused IL12 shows potent antitumor activity by generating memory CD8+ T cells

OncoImmunology, 2018
Interleukin-12 (IL12) (p35/p40 complex) is a heterodimeric cytokine with potent anti-tumor activity. However, its short serum half-life and high dose-related toxicities limit its clinical efficacy.
Keunok Jung, Ji-Hee Ha, Jung-Eun Kim, Jeong-Ah Kim, Ye-Jin Kim, Chul-Ho Kim, Yong-Sung Kim   +6 more
doaj   +1 more source

cDNA Cloning of Biologically Active Chicken Interleukin-18 [PDF]

, 2000
By searching a chicken EST database, we identified a cDNA clone that appeared to contain the entire open reading frame (ORF) of chicken interleukin-18 (ChIL-18).
Stäheli, Peter, Peter Staeheli, Staeheli, Peter, Baeuerle, Patrick A., Kaspers, Bernd, Kirsten Schneider, Schneider, Kirsten, Baeuerle, Daniela, Daniela Baeuerle, Kirsten C. Weining, Puehler, Florian, Elvers, Sandra, Weining, Kirsten C., Florian Puehler, Sandra Elvers, Bernd Kaspers   +15 more
core   +1 more source

Co-stimulation of the fc receptor and interleukin-12 receptor on human natural killer cells leads to increased expression of cd25

OncoImmunology, 2018
Natural killer (NK) cells serve a critical role in the immune response against microbes and developing tumors. We have demonstrated that NK cells produce stimulatory cytokines (e.g., IFN-γ) in response to potent stimulation via immobilized IgG (to engage
Megan C. Duggan, Amanda R. Campbell, Elizabeth L. McMichael, Kallan S. Opheim, Kala M. Levine, Neela Bhave, Michelle C. Culbertson, Tiffany Noel, Lianbo Yu, WE Carson   +9 more
doaj   +1 more source