Results 21 to 30 of about 986,782 (400)

The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling [PDF]

, 2008
The kinases MSK1 and MSK2 are activated 'downstream' of the p38 and Erk1/2 mitogen-activated protein kinases. Here we found that MSK1 and MSK2 were needed to limit the production of proinflammatory cytokines in response to stimulation of primary ...
A Cuenda, A Soloaga, A Sommer, Andrew Wingate, B Echtenacher, B Echtenacher, BG Stiles, C Platzer, CA Gogos, Claire E Monk, Claus Johansen, D Rittirsch, DM Dambach, ER Ottosen, F Hildebrand, FY Liew, GR Wiggin, GY Song, H Chi, J Bain, J Darragh, J Han, J Rouse, J Simon C Arthur, Jin Mo Park, JM Park, Joanne Darragh, Joanne McIlrath, JS Arthur, JS Arthur, Julia M Carr, KV Salojin, Lars Iversen, M Brook, M Hammer, M Saraiva, ML Steinhauser, MS Lee, NC Riedamann, NW Freshney, Olga Ananieva, OM Peck-Palmer, P Chen, PC Cheung, PJ Murray, Q Zhao, R Kuhn, Rachel Toth, SE Moreno, SJ O'Keefe, SM Miggin, SQ Latifi, Susana G Santos, T Kawai, T Lang, T van der Poll, VA Beardmore, VS Carl, WJ Hubbard, X Zhang, Y Kalechman, YJ Kang   +61 more
core   +3 more sources

Administration of fusion cytokines induces tumor regression and systemic antitumor immunity

MedComm, 2021
It is difficult to improve the curative effects of cancer immunotherapy on solid tumors. Cytokines, as powerful immune regulators, show potential in activating host antitumor immunity.
Jinyu Zhang, Xuan Zhao
doaj   +1 more source

Aprotinin reduces cardiac troponin I release and inhibits apoptosis of polymorphonuclear cells during off-pump coronary artery bypass surgery [PDF]

, 2008
Objectives: In addition to blood-sparing effects, aprotinin may have cardioprotective and anti-inflammatory effects during cardiopulmonary bypass-assisted cardiac surgery.
Bert, C., Ceuppens, J., De Buck, F., Delforge, M., Kasran, A., Meyns, B., Sergeant, P., Van Duppen, V., Van Hemelrijck, J., Wouters, Patrick   +9 more
core   +2 more sources

Serum Levels of Il-12 and Il-23 in Breast Cancer Patients Infected with Toxoplasma gondii: A Case-Control Study

Iranian Journal of Parasitology, 2020
Background: The possible risk factor of Toxoplasma infection and its possible correlation with Interleukin-12 (IL-12) and Interleukin-23 (IL-23) in breast cancer patients was investigated. Methods: Overall, 190 female patients referred to the Oncology
Maha Mustafa ASSIM, Entsar Jabbar SAHEB
doaj   +1 more source

Interleukin-12 p40 secretion by cutaneous CD11c(+) and F4/80(+) cells is a major feature of the innate immune response in mice that develop Th1-mediated protective immunity to Schistosoma mansoni [PDF]

, 2003
Radiation-attenuated (RA) schistosome larvae are potent stimulators of innate immune responses at the skin site of exposure (pinna) that are likely to be important factors in the development of Th1-mediated protective immunity.
Anderson, S, Hogg, K G, Kumkate, S, Mountford, A P   +3 more
core   +2 more sources

Inhibition of MC38 colon cancer growth by multicomponent chemoimmunotherapy with anti-IL-10R antibodies, HES-MTX nanoconjugate, depends on application of IL-12, IL-15 or IL-18 secreting dendritic cell vaccines

Frontiers in Immunology, 2023
BackgroundThe tumor microenvironment (TME) provides a conducive environment for the growth and survival of tumors. Negative factors present in TME, such as IL-10, may limit the effectiveness of cellular vaccines based on dendritic cells, therefore, it is
Katarzyna Węgierek-Ciura, Jagoda Mierzejewska, Agnieszka Szczygieł, Joanna Rossowska, Anna Wróblewska, Marta Świtalska, Tomasz M. Goszczyński, Bożena Szermer-Olearnik, Elżbieta Pajtasz-Piasecka   +8 more
doaj   +1 more source

The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP-lpr/lpr mice [PDF]

, 1996
MRL/MP-lpr/lpr (MRL/lpr) mice develop a spontaneous autoimmune disease. Serum from these mice contained significantly higher concentrations of nitrite/nitrate than serum from age-matched control MRL/MP-+/+ (MRL/+), BALB/c or CBA/6J mice.
Feng, G.J., Huang, F.P., Liew, F.Y., Lindop, G., Stott, D.I.   +4 more
core   +3 more sources

Factors Associated With In Vitro Interferon-gamma Production in Tuberculosis

Journal of the Formosan Medical Association, 2011
Macrophage activation assisted by interferon-gamma (IFN-γ) is a primary mechanism by which Mycobacterium tuberculosis is killed, but IFN-γ (production is inhibited in tuberculosis (TB) patients. The production of IFN-γ is influenced by many factors, such
Chung-Chieh Yu, Yu-Chih Liu, Chien-Ming Chu, Duen-Yau Chuang, Wen-Chen Wu, Huang-Pin Wu   +5 more
doaj   +1 more source

Tumor cell-based vaccine contributes to local tumor irradiation by eliciting a tumor model-dependent systemic immune response

Frontiers in Immunology, 2022
Multimodal treatment approaches, such as radio-immunotherapy, necessitate regimen optimization and the investigation of the interactions of different modalities. The aim of this study was two-fold.
Tinkara Remic, Tinkara Remic, Gregor Sersa, Gregor Sersa, Kristina Levpuscek, Kristina Levpuscek, Ursa Lampreht Tratar, Ursa Lampreht Tratar, Katja Ursic Valentinuzzi, Katja Ursic Valentinuzzi, Andrej Cör, Andrej Cör, Urska Kamensek, Urska Kamensek   +13 more
doaj   +1 more source

Relationship between levels of inflammatory cytokines in the genital tract and CD4+ cell counts in women with acute HIV-1 infection. [PDF]

, 2008
Inflammatory responses at mucosal surfaces after human immunodeficiency virus type 1 (HIV-1) transmission may influence disease outcome. We evaluated levels of interleukin (IL)-1beta, IL-6, tumor necrosis factor-alpha, IL-8, IL-10, and IL-12 in genital ...
Bebell, Lisa M, Iriogbe, Itua, Karim, Quarraisha Abdool, Karim, Salim Abdool, Mlisana, Koleka, Passmore, Jo-Ann, van Loggerenberg, Francois, Williamson, Carolyn   +7 more
core   +1 more source