Results 11 to 20 of about 71,511,565 (289)

Interleukin-12

Inpharma Weekly, 1998
Obecná charakteristika cytokinů, historie bádání, receptory pro cytokiny a přenos signálu do buňky interleukin-12, jeho struktura, geny pro IL-12, receptor pro IL-12, jeho zdroje, biologické působení, nežádoucí účinky a klinické využití.Dokončená práce s
Richard Chizzonite, Ueli Gubler, Jeanne Magram, Alvin S. Stern   +3 more
core   +4 more sources

The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP-lpr/lpr mice [PDF]

, 1996
MRL/MP-lpr/lpr (MRL/lpr) mice develop a spontaneous autoimmune disease. Serum from these mice contained significantly higher concentrations of nitrite/nitrate than serum from age-matched control MRL/MP-+/+ (MRL/+), BALB/c or CBA/6J mice.
Liew, F.Y., Feng, G.J., Lindop, G., Huang, F.P., Stott, D.I.   +4 more
core   +9 more sources

Evaluation of Salivary Interleukin 2 (IL-2) and Interleukin 12(IL-12) in Recurrent Aphthous Stomatitis [PDF]

Ibn Al-Haitham Journal for Pure and Applied Sciences
Recurrent aphthous stomatitis (RAS) is  a common kind of excruciating mouth mucosal disease. Despite their high prevalence, etiopathogenesis remains unclear.
Sura Farhan Saeed, Zainab Abduljabar Aldhaher   +1 more
doaj   +2 more sources

Interleukin-12 Message in a Bottle

Clinical Cancer Research, 2020
Abstract IL12 is a very potent cancer immunotherapy agent, but is difficult to harness safely if given systemically. Local gene transfer aims to confine the effects of IL12 to malignant tissues, thus avoiding toxicity. Lipid-nanoparticle mRNA achieves IL12 expression and efficacy in mouse models, opening the way to an ongoing trial.
Assunta Cirella, Pedro Berraondo, Claudia Augusta Di Trani, Ignacio Melero   +3 more
openaire   +3 more sources

Non-Clinical In Vitro Evaluation of Antibiotic Resistance Gene-Free Plasmids Encoding Human or Murine IL-12 Intended for First-in-Human Clinical Study

Pharmaceutics, 2021
Interleukin 12 (IL-12) is a key cytokine that mediates antitumor activity of immune cells. To fulfill its clinical potential, the development is focused on localized delivery systems, such as gene electrotransfer, which can provide localized delivery of ...
Spela Kos, Masa Bosnjak, Tanja Jesenko, Bostjan Markelc, Urska Kamensek, Katarina Znidar, Urska Matkovic, Andrej Rencelj, Gregor Sersa, Rosana Hudej, Aneja Tuljak, Matjaz Peterka, Maja Cemazar   +12 more
doaj   +1 more source

Intravaginal Administration of Interleukin 12 during Genital Gonococcal Infection in Mice Induces Immunity to Heterologous Strains of Neisseria gonorrhoeae

mSphere, 2018
It has previously been shown that genital tract infection with Neisseria gonorrhoeae in mice does not induce a state of protective immunity against reinfection but instead suppresses the development of adaptive immune responses against N.
Yingru Liu, Julianny Perez, Laura A. Hammer, Heather C. Gallagher, Magdia De Jesus, Nejat K. Egilmez, Michael W. Russell   +6 more
doaj   +1 more source

Biochemical, Molecular and Histopathological changes of rheumatoid arthritis induced experimentally in rats [PDF]

Benha Veterinary Medical Journal, 2023
Complete Freund's adjuvant (CFA) is a mixture of dessicated mycobacterium in mannide monooleate and paraffin oil that causes tissue death, lesions, and inflammation.
Nihal Amer, Omnia abd elhamid, Hussein Abd Elmaksoud Ali, Naglaa Alhusseini   +3 more
doaj   +1 more source

Factors Associated With In Vitro Interferon-gamma Production in Tuberculosis

Journal of the Formosan Medical Association, 2011
Macrophage activation assisted by interferon-gamma (IFN-γ) is a primary mechanism by which Mycobacterium tuberculosis is killed, but IFN-γ (production is inhibited in tuberculosis (TB) patients. The production of IFN-γ is influenced by many factors, such
Chung-Chieh Yu, Yu-Chih Liu, Chien-Ming Chu, Duen-Yau Chuang, Wen-Chen Wu, Huang-Pin Wu   +5 more
doaj   +1 more source

Inhibition of MC38 colon cancer growth by multicomponent chemoimmunotherapy with anti-IL-10R antibodies, HES-MTX nanoconjugate, depends on application of IL-12, IL-15 or IL-18 secreting dendritic cell vaccines

Frontiers in Immunology, 2023
BackgroundThe tumor microenvironment (TME) provides a conducive environment for the growth and survival of tumors. Negative factors present in TME, such as IL-10, may limit the effectiveness of cellular vaccines based on dendritic cells, therefore, it is
Katarzyna Węgierek-Ciura, Jagoda Mierzejewska, Agnieszka Szczygieł, Joanna Rossowska, Anna Wróblewska, Marta Świtalska, Tomasz M. Goszczyński, Bożena Szermer-Olearnik, Elżbieta Pajtasz-Piasecka   +8 more
doaj   +1 more source

Oral administration of Bifidobacterium breve promotes antitumor efficacy via dendritic cells-derived interleukin 12

OncoImmunology, 2021
Recent advances in immunotherapy, as a part of the multidisciplinary therapy, has gradually gained more attention. However, only a small proportion of patients who sensitive to the therapy could gain benefits.
Qingxiang Li, Yuke Li, Yifei Wang, Le Xu, Yuxing Guo, Yixiang Wang, Lin Wang, Chuanbin Guo   +7 more
doaj   +1 more source