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Localized Interleukin-12 for Cancer Immunotherapy
Frontiers in Immunology, 2020 Interleukin-12 (IL-12) is a potent, pro-inflammatory type 1 cytokine that has long been studied as a potential immunotherapy for cancer. Unfortunately, IL-12's remarkable antitumor efficacy in preclinical models has yet to be replicated in humans.
Khue G. Nguyen +6 more
doaj +2 more sources
Interleukin-12 family cytokines and sarcoidosis
Frontiers in Pharmacology, 2014 Sarcoidosis is a systemic granulomatous disease predominantly affecting the lungs. It is believed to be caused by exposure to pathogenic antigens in genetically susceptible individuals but the causative antigen has not been identified.
Sabine eRingkowski +3 more
doaj +2 more sources
Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent [PDF]
Nature Communications, 2017 Interleukin-12 (IL-12) has emerged as one of the most potent agents for anti-tumor immunotherapy. However, potentially lethal toxicity associated with systemic administration of IL-12 precludes its clinical application.
Pengju Wang +16 more
openalex +2 more sources
Combined Stimulation with Interleukin-18 and Interleukin-12 Potently Induces Interleukin-8 Production by Natural Killer Cells [PDF]
Journal of Innate Immunity, 2017 The combination of interleukin (IL)-18 and IL-12 (IL-18+IL-12) potently stimulates natural killer (NK) cells, triggering an innate immune response to infections and cancers.
Sophie M. Poznanski +6 more
openalex +2 more sources
Interleukin-12 as an in situ cancer vaccine component: a review
Cancer Immunology and Immunotherapy, 2022 Interleukin-12 (IL-12) is a type I cytokine involved in both innate and adaptive immunity that stimulates T and natural killer cell activity and induces interferon gamma production. IL-12 has been identified as a potential immunotherapeutic component for
Emily Cheng +3 more
semanticscholar +1 more source
Interleukin 39: a new member of interleukin 12 family
Central European Journal of Immunology, 2020 Interleukin (IL)-12 family member is a heterodimer glycoprotein, composed of two covalently linked subunits, α and β chains. The α subunit consists of IL-23p19, IL-27p28, and IL-12p35, and the β subunit includes IL-12p40 and Epstein-Barr virus-induced ...
Zhiyu Lu +4 more
semanticscholar +1 more source
Interleukins IL-6, IL-8, IL-10, IL-12 and periimplant disease. An update [PDF]
, 2011 Introduction: A study is made of the usefulness of cytokines (such as interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10) and interleukin-12 (IL-12)) as markers of periimplant disease (mucositis and periimplantitis).
Alegre Domingo, Teresa +4 more
core +1 more source
mSphere, 2018 It has previously been shown that genital tract infection with Neisseria gonorrhoeae in mice does not induce a state of protective immunity against reinfection but instead suppresses the development of adaptive immune responses against N.
Yingru Liu +6 more
doaj +1 more source
BMC Medical Genetics, 2020 Background Intervertebral disc degeneration (IVDD) is an age-related degenerative disease, presenting with low back pain or radicular pain. The inflammatory changes would occur in discs in the process of IVDD.
Sara Hanaei +6 more
doaj +1 more source