Results 21 to 30 of about 7,946,940 (284)

Correlation between serum levels of interleukins 10 and 12 and thrombocytopenia in hepatitis C cirrhotic (class A) patients

Journal of Venomous Animals and Toxins including Tropical Diseases, 2010
Hepatitis C virus (HCV) patients commonly have low platelet counts; however, the exact role of HCV infection in thrombocytopenia is unknown. This work aimed to study the serum levels of interleukins (IL) 10 and 12 in patients with mild and moderate ...
N Abdallah, HK Abdel Aziz, NA Hamed, M Gamal   +3 more
doaj   +1 more source

Localized Interleukin-12 for Cancer Immunotherapy

Frontiers in Immunology, 2020
Interleukin-12 (IL-12) is a potent, pro-inflammatory type 1 cytokine that has long been studied as a potential immunotherapy for cancer. Unfortunately, IL-12's remarkable antitumor efficacy in preclinical models has yet to be replicated in humans.
Khue G. Nguyen, Maura R. Vrabel, Siena M. Mantooth, Jared J. Hopkins, Ethan S. Wagner, Taylor A. Gabaldon, David A. Zaharoff   +6 more
doaj   +1 more source

Transgenic viral expression of PH-20, IL-12, and sPD1-Fc enhances immune cell infiltration and anti-tumor efficacy of an oncolytic virus

Molecular Therapy: Oncolytics, 2023
Oncolytic viruses are of significant clinical interest due to their ability to directly infect and kill tumors and enhance the anti-tumor immune response.
Soon-Oh Hong, Joonsung Kim, Sungmin Lee, Jaeil Shin, Hwanjun Choi, Eunjin Lee, Hyesoo Kang, Hyesun Lee, Soondong Lee, Naeun Yun, Jiwon An, Heonsik Choi, Hyeree Kim, Wonseok Kang, Yeup Yoon, Sujeong Kim   +15 more
doaj   +1 more source

Significance of the determination of proinflammatory cytokines in the serum of polytraumatized patients with sepsis [PDF]

Vojnosanitetski Pregled, 2004
Severe sepsis and trauma complicated with multiple organ dysfunction syndrome (MODS) are among the leading causes of death in intensive therapy units with mortality rate exceeding 50%.
Šurbatović Maja, Jovanović Krsta, Vojvodić Danilo, Filipović Nikola, Babić Dragan D.   +4 more
doaj   +1 more source

Engineering Rapalog-Inducible Genetic Switches Based on Split-T7 Polymerase to Regulate Oncolytic Virus-Driven Production of Tumour-Localized IL-12 for Anti-Cancer Immunotherapy

Pharmaceuticals, 2023
The approval of different cytokines as anti-neoplastic agents has been challenged by dose-limiting toxicities. Although reducing dose levels affords improved tolerability, efficacy is precluded at these suboptimal doses.
Nikolas T. Martin, Mathieu J. F. Crupi, Zaid Taha, Joanna Poutou, Jack T. Whelan, Sydney Vallati, Julia Petryk, Ricardo Marius, Bradley Austin, Taha Azad, Mason Boulanger, Tamara Burgess, Ilson Sanders, Camille Victoor, Bryan C. Dickinson, Jean-Simon Diallo, Carolina S. Ilkow, John C. Bell   +17 more
doaj   +1 more source

cDNA Cloning of Biologically Active Chicken Interleukin-18 [PDF]

, 2000
By searching a chicken EST database, we identified a cDNA clone that appeared to contain the entire open reading frame (ORF) of chicken interleukin-18 (ChIL-18).
Stäheli, Peter, Peter Staeheli, Staeheli, Peter, Baeuerle, Patrick A., Kaspers, Bernd, Kirsten Schneider, Schneider, Kirsten, Baeuerle, Daniela, Daniela Baeuerle, Kirsten C. Weining, Puehler, Florian, Elvers, Sandra, Weining, Kirsten C., Florian Puehler, Sandra Elvers, Bernd Kaspers   +15 more
core   +1 more source

Interleukin-12 in infectious diseases [PDF]

Clinical Microbiology Reviews, 1997
Interleukin-12 (IL-12) is a potent immunoregulatory cytokine that is crucially involved in a wide range of infectious diseases. In several experimental models of bacterial, parasitic, viral, and fungal infection, endogenous IL-12 is required for early control of infection and for generation and perhaps maintenance of acquired protective immunity ...
ROMANI, Luigina, PUCCETTI, Paolo, BISTONI, Francesco   +2 more
openaire   +3 more sources

Zirconium oxide nanoparticles: Protocolicidal effect against hydatid cyst protoscoleces with interleukins evaluation in mice [PDF]

Iraqi Journal of Veterinary Sciences
The current study investigated the effect of zirconium oxide nanoparticles NPs on the levels of interleukins in mice inoculated with protoscoleces of Echinococcus granulosus, after exposure to ZrO2 NPs at the doses,5,10,50, and 100 µg /ml for 30 ...
Zina A. Mahmoud, Asmaa A. Ali, Luay J. Rashan   +2 more
doaj   +1 more source

Heterogeneity in the granulomatous response to mycobacterial infection in patients with defined genetic mutations in the interleukin 12-dependent interferon-gamma production pathway

, 2002
Granulomatous Diseases Review Heterogeneity in the granulomatous response to mycobacterial infection in patients with defined genetic mutations in the interleukin 12-dependent interferon-gamma production ...
Kumararatne, D.S., Baretto, Richard, De Heer, E., J.F. EMILE, Ottenhoff, THM, De Heer, E, Edgar, JD, Binch, J., Ottenhoff, T.H., Casanova, J.L., Lammas, David, Lammas, D.A., Edgar, J, Kumararatne, DS, Panchalingam, S, Novelli, V., E. DE HEER, Drysdale, P, Binch, J, Ottenhoff, TH, Panchalingam, S., Emile, JF, Drysdale, Pamela, C. MACLENNAN, T. H. M. OTTENHOFF, Ben-smith, Anne, Novelli, V, P. DRYSDALE, MacLennan, Calman, R. BARETTO, Casanova, JL, J. BINCH, Ben-Smith, A., Casanova, J-L, Ben-Smith, A, Drysdale, P., Emile, J.F., D. S. KUMARARATNE, Baretto, R, Baretto, R., S. PANCHALINGAM, J.-L. CASANOVA, MacLennan, C, J. D. EDGAR, A. BEN-SMITH, Kumararatne, Dinakantha, D. A. LAMMAS, MacLennan, C., Lammas, David A, V. NOVELLI   +49 more
core   +1 more source

Co-stimulation of the fc receptor and interleukin-12 receptor on human natural killer cells leads to increased expression of cd25

OncoImmunology, 2018
Natural killer (NK) cells serve a critical role in the immune response against microbes and developing tumors. We have demonstrated that NK cells produce stimulatory cytokines (e.g., IFN-γ) in response to potent stimulation via immobilized IgG (to engage
Megan C. Duggan, Amanda R. Campbell, Elizabeth L. McMichael, Kallan S. Opheim, Kala M. Levine, Neela Bhave, Michelle C. Culbertson, Tiffany Noel, Lianbo Yu, WE Carson   +9 more
doaj   +1 more source