Results 21 to 30 of about 680,838 (259)
Pharmaceuticals, 2023 The approval of different cytokines as anti-neoplastic agents has been challenged by dose-limiting toxicities. Although reducing dose levels affords improved tolerability, efficacy is precluded at these suboptimal doses.
Nikolas T. Martin +17 more
doaj +1 more source
Zirconium oxide nanoparticles: Protocolicidal effect against hydatid cyst protoscoleces with interleukins evaluation in mice [PDF]
Iraqi Journal of Veterinary SciencesThe current study investigated the effect of zirconium oxide nanoparticles NPs on the levels of interleukins in mice inoculated with protoscoleces of Echinococcus granulosus, after exposure to ZrO2 NPs at the doses,5,10,50, and 100 µg /ml for 30 ...
Zina A. Mahmoud +2 more
doaj +1 more source
Interleukin-12 in Human Milk [PDF]
Pediatric Research, 1999 The presence of interleukin-12 (IL-12) in 39 samples of human milk was investigated using the enzyme-linked immunosorbent assay. IL-12 (>40 pg/mL) was detected in 24 of the 39 samples collected (1408 +/- 2256 pg/mL, mean +/- SD, n = 24). A range of concentrations of IL-12 was observed in colostrum, transitional, and mature milk, with an apparent ...
D L, Bryan, J S, Hawkes, R A, Gibson
openaire +2 more sources
OncoImmunology, 2018 Natural killer (NK) cells serve a critical role in the immune response against microbes and developing tumors. We have demonstrated that NK cells produce stimulatory cytokines (e.g., IFN-γ) in response to potent stimulation via immobilized IgG (to engage
Megan C. Duggan +9 more
doaj +1 more source
Fasting metabolism modulates the interleukin-12/interleukin-10 cytokine axis.
PLoS ONE, 2017 A crucial role of cell metabolism in immune cell differentiation and function has been recently established. Growing evidence indicates that metabolic processes impact both, innate and adaptive immunity.
Johannes J Kovarik +16 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2022 Alphavirus vectors based on self-amplifying RNA (saRNA) generate high and transient levels of transgene expression and induce innate immune responses, making them an interesting tool for antitumor therapy.
Noelia Silva-Pilipich +5 more
doaj +1 more source
The Toxicology of Interleukin-12: A Review [PDF]
Toxicologic Pathology, 1999 Recombinant murine interleukin (IL)-12 (rmIL-12) exhibits antitumor, antiviral, and antimicrobial activities and can modify allergic inflammatory reactions in animal models. Recombinant human IL-12 (rhIL-12) is currently in clinical trials for treatment of cancer, asthma, and viral hepatitis.
B D, Car +3 more
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Febrile neutropenia (FN) is a frequent and serious complication in children receiving cancer therapy. Standardizing FN management across Asia is challenging due to variable healthcare infrastructure, diagnostic capacity, and infection patterns; however, it could improve resource use and patient outcomes.
Joliza Patricia Cañeba +29 more
wiley +1 more source
Interleukin-12 family cytokines and sarcoidosis
Frontiers in Pharmacology, 2014 Sarcoidosis is a systemic granulomatous disease predominantly affecting the lungs. It is believed to be caused by exposure to pathogenic antigens in genetically susceptible individuals but the causative antigen has not been identified.
Sabine eRingkowski +3 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source