Results 1 to 10 of about 69,683,828 (280)

Advances in IL–15–Based Cancer Immunotherapy and Divergent Immunological Effects of IL–2 and IL–15 Signaling via the Shared IL–2Rβγ Receptor [PDF]

Frontiers in Immunology
Interleukin-15 (IL-15) has emerged as a central cytokine for next-generation cancer immunotherapy because of its unique ability to sustain the survival, proliferation, and cytotoxic function of memory CD8+ T cells and natural killer (NK) cells without ...
Huiquan Gao, Tao Ma, Qinqin Jiang, Lanfang Gao, Jinfang Li, Shubo Wang, Ziyong Liu, Zhixin Zhang, Gang Wu, Wenxin He, Fuxin Zhou   +10 more
doaj   +2 more sources

IL-15, IL-18 and IL-21 Along the Stress–Smoking–Periodontal Health Axis: A Cross-Sectional Study in Mexican Adults [PDF]

Biomedicines
From a psychoneuroimmunology standpoint, stress and cigarette smoking are plausible modulators of periodontal inflammation through neuroendocrine–immune pathways and cytokine networks. Interleukin-18 (IL-1 family), interleukin-21 (common γ-chain cytokine)
Carmen Celina Alonso-Sánchez, Juan Manuel Guzmán-Flores, Julieta Sarai Becerra-Ruiz, Celia Guerrero-Velázquez, María Luisa Ramírez-de los Santos, Edgar Iván López-Pulido, Saúl Ramírez-de los Santos   +6 more
doaj   +2 more sources

IL-15Rα-Independent IL-15 Signaling in Non-NK Cell-Derived IFNγ Driven Control of Listeria monocytogenes

Frontiers in Immunology, 2021
Interleukin-15, produced by hematopoietic and parenchymal cells, maintains immune cell homeostasis and facilitates activation of lymphoid and myeloid cell subsets.
Madhuparna Nandi, Mitterrand Muamba Moyo, Sakina Orkhis, Jeanne Masunga Faida Mobulakani, Marc-André Limoges, Fjolla Rexhepi, Marian Mayhue, Anny Armas Cayarga, Gisela Cofino Marrero, Subburaj Ilangumaran, Subburaj Ilangumaran, Alfredo Menendez, Alfredo Menendez, Sheela Ramanathan, Sheela Ramanathan   +14 more
doaj   +1 more source

The roles of different forms of IL-15 in human melanoma progression

Frontiers in Immunology, 2023
BackgroundMelanoma is a lethal skin cancer, and the risk of developing it is increased by exposure to ultraviolet (UV) radiation. The production of cytokines such as interleukin-15 (IL-15), induced by the exposure of skin cells to UV rays, could also ...
Sabina Di Matteo, Enrico Munari, Piera Filomena Fiore, Silvia Santopolo, Camilla Sampaoli, Andrea Pelosi, Salem Chouaib, Salem Chouaib, Nicola Tumino, Paola Vacca, Francesca Romana Mariotti, Stefan Ebert, Markus Machwirth, Dorothee Haas, Marco Pezzullo, Gabriella Pietra, Gabriella Pietra, Melania Grottoli, Stephanie Buart, Erwan Mortier, Erwan Mortier, Enrico Maggi, Lorenzo Moretta, Ignazio Caruana, Bruno Azzarone   +24 more
doaj   +1 more source

Ancient Cytokine Interleukin 15-Like (IL-15L) Induces a Type 2 Immune Response

Frontiers in Immunology, 2020
Related interleukin-2, -15, and -15-like (IL-2, -15, and -15L) are ancient cytokines, with all three genes surviving in extant fish and some mammals. The present study is the first to identify IL-15L functions, namely in rainbow trout.
Takuya Yamaguchi, Chia Jung Chang, Axel Karger, Markus Keller, Florian Pfaff, Eakapol Wangkahart, Tiehui Wang, Christopher J. Secombes, Azusa Kimoto, Mitsuru Furihata, Keiichiro Hashimoto, Uwe Fischer, Johannes M. Dijkstra   +12 more
doaj   +1 more source

Oncolytic therapy with recombinant vaccinia viruses targeting the interleukin-15 pathway elicits a synergistic response

Molecular Therapy: Oncolytics, 2023
We developed recombinant variants of oncolytic vaccinia virus LIVP strain expressing interleukin-15 (IL-15) or its receptor subunit alpha (IL-15Rα) to stimulate IL-15-dependent immune cells.
Yasmin Shakiba, Pavel O. Vorobyev, Gaukhar M. Yusubalieva, Dmitry V. Kochetkov, Ksenia V. Zajtseva, Marat P. Valikhov, Vladimir A. Kalsin, Fedor G. Zabozlaev, Alevtina S. Semkina, Alexander V. Troitskiy, Vladimir P. Baklaushev, Peter M. Chumakov, Anastasia V. Lipatova   +12 more
doaj   +1 more source

Moderate-intensity continuous training and probiotic consumption on IL-15 gene expression in an animal model of non-alcoholic steatosis [PDF]

Journal of Exercise & Organ Cross Talk, 2022
Steatosis is the most important cause for chronic liver disease, from simple steatosis to advanced stages such as liver fibrosis and cirrhosis and liver cancer. In this study, the effect of MICT and probiotic consumption on IL15 gene expression in animal
Asal Ziloubaf, Shahin Riyahi Malayeri, Amin Feli, Masoumeh Hosseini, Ali Azadi, Motahare Ghane   +5 more
doaj   +1 more source

Which is the ideal JAK inhibitor for alopecia areata – Baricitinib, tofacitinib, ritlecitinib or ifidancitinib - Revisiting the immunomechanisms of the JAK pathway

Indian Dermatology Online Journal, 2023
Alopecia areata (AA) is an immune-mediated condition, clinically manifesting as non-cicatricial patches of alopecia. It is often a self-limiting condition; however, regrowth of hair can take a long period of time, resulting in significant psychological ...
Kabir Sardana, Savitha Bathula, Ananta Khurana   +2 more
doaj   +1 more source

Increase in IL-15 levels in patients with alopecia areata

Journal of Education, Health and Sport, 2020
Introduction and purpose: Alopecia areata (AA) is a condition that causes non-scarring hair loss (often with acute onset). Alopecia areata in the population occurs in 0.1-0.2% of people, with a similar frequency in men and women.
Dominika Katarzyna Madras, Agata Rocka, Faustyna Piędel, Dominika Psiuk, Emilia Nowak   +4 more
doaj   +1 more source

Expand to shield: IL-15 and in situ lymphocytic proliferation

OncoImmunology, 2021
The tumor microenvironment includes a complex network of cytokines and chemokines that contribute to shaping the intratumoral immune reaction. Understanding the mechanisms leading to immune-hot (Immunoscore-high) altered (excluded and immunosuppressed ...
Gabriela Bindea, Bernhard Mlecnik, Jérôme Galon   +2 more
doaj   +1 more source