Results 31 to 40 of about 69,683,828 (280)

DEVELOPMENT OF A REAL-TIME RT-PCR-BASED TEST PANEL FOR ASSESSMENT OF CYTOKINE PROFILE IN MONONUCLEAR CELLS FROM BLOOD AND SYNOVIAL FLUID IN RHEUMATOID ARTHRITIS

Медицинская иммунология, 2014
. An imbalance between pro- and anti-inflammatory cytokine synthesis plays a crucial role in pathogenesis of rheumatoid arthritis (RA), including erosive joint lesions.
D. Yu. Trofimov, O. V. Burmenskaya, E. I. Bateneva, L. P. Alexeev, E. L. Nasonov, E. N. Alexandrova, A. A. Novikov   +6 more
doaj   +1 more source

IL-15 receptor alpha as the magic wand to boost the success of IL-15 antitumor therapies: The upswing of IL-15 transpresentation [PDF]

Pharmacology & Therapeutics, 2017
Interleukin (IL)-15 as a stand-alone therapy can activate the antitumor functions of immune effector cells resulting in significant tumor regression. Interestingly, combining IL-15 with the α-moiety of its receptor (IL-15Rα), also called IL-15 transpresentation, increases the in vivo half-life of IL-15 and enhances binding of IL-15 with cells ...
Van den Bergh, Johan M.J., Lion, Eva, Van Tendeloo, Viggo F.I., Smits, Evelien L.J.M.   +3 more
openaire   +3 more sources

Co-expression IL-15 receptor alpha with IL-15 reduces toxicity via limiting IL-15 systemic exposure during CAR-T immunotherapy

Journal of Translational Medicine, 2022
Background Chimeric antigen receptor (CAR)-T cell therapy is a powerful adoptive immunotherapy against both B-cell malignancies and some types of solid tumors.
Ying Zhang, Qinghui Zhuang, Fang Wang, Can Zhang, Chang Xu, Aiqin Gu, William H. Zhong, Yi Hu, Xiaosong Zhong   +8 more
doaj   +1 more source

Combined IL-15/IL-15Rα Immunotherapy Maximizes IL-15 Activity In Vivo [PDF]

The Journal of Immunology, 2006
Abstract IL-15 has substantial potential as an immunotherapeutic agent for augmenting immune responses. However, the activity of IL-15 is mediated by a unique mechanism in which the cytokine is transpresented by cell-bound high-affinity IL-15Rα to target cells expressing the IL-15Rβ and the common γ-chain.
Thomas A, Stoklasek, Kimberly S, Schluns, Leo, Lefrançois   +2 more
openaire   +2 more sources

IL-15, TIM-3 and NK cells subsets predict responsiveness to anti-CTLA-4 treatment in melanoma patients

OncoImmunology, 2017
Despite the success of immune checkpoint blockade in melanoma, the majority of patients do not respond. We hypothesized that the T and NK cell subset frequencies and expression levels of their receptors may predict responses and clinical outcome of anti ...
Rossana Tallerico, Costanza M. Cristiani, Elina Staaf, Cinzia Garofalo, Rosa Sottile, Mariaelena Capone, Yago Pico de Coaña, Gabriele Madonna, Eleonora Palella, Maria Wolodarski, Valentina Carannante, Domenico Mallardo, Ester Simeone, Antonio M. Grimaldi, Sofia Johansson, Paolo Frumento, Elio Gulletta, Andrea Anichini, Francesco Colucci, Gennaro Ciliberto, Rolf Kiessling, Klas Kärre, Paolo A. Ascierto, Ennio Carbone   +23 more
doaj   +1 more source

Elevated Serum Levels of Interleukin-15 in Pemphigus Vulgaris Patients: A Potential Therapeutic Target

Dermatology Practical & Conceptual, 2022
introduction: IL-15 as a member of the immunoregulatory cytokines family is associated with the development of the autoimmune or chronic inflammatory disease.
Maedeh Kheirodin, Zohreh Tehranchinia, Yasaman Ketabi, Soheil Tavakolpour, Sahar Dadkhahfar, Masoomeh Faghankhani, Hassan Vahidnezhad, Nikoo Mozafari   +7 more
doaj   +1 more source

Interleukin-15 enhances human neutrophil phagocytosis by a Syk-dependent mechanism: importance of the IL-15Rα chain

, 2004
International audienceInterleukin-15 (IL-15) is a cytokine that possesses interesting, potential therapeutic properties. However, based on several parameters including activation of neutrophils, it is also recognized as a proinflammatory cytokine.
Denis Girard, Girard, Denis, Claude Ratthé, Ratthé, Claude   +3 more
core   +1 more source

Targeting Prostate Cancer Using Intratumoral Cytotopically Modified Interleukin-15 Immunotherapy in a Syngeneic Murine Model

ImmunoTargets and Therapy, 2020
Efthymia Papaevangelou,1 Dorota Smolarek,1 Richard A Smith,1 Prokar Dasgupta,1,2 Christine Galustian1 1Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King’s College London, Guy’s Hospital, London, UK ...
Papaevangelou E, Smolarek D, Smith RA, Dasgupta P, Galustian C   +4 more
doaj  

New, Low–Molecular Weight Chemical Compounds Inhibiting Biological Activity of Interleukin 15

Molecules, 2023
Chronic overproduction of IL–15 contributes to the pathogenesis of numerous inflammatory and autoimmune disorders. Experimental methods used to reduce the cytokine activity show promise as potential therapeutic approaches to modify IL–15 signaling and ...
Piotr Krzeczyński, Małgorzata Dutkiewicz, Oliwia Zegrocka-Stendel, Bartosz Trzaskowski, Katarzyna Koziak   +4 more
doaj   +1 more source

Cytoplasmic tail of IL-13Ralpha2 regulates IL-4 signal transduction

, 2009
IL (interleukin)-4 and IL-13 are key cytokines in the pathogenesis of allergic inflammatory disease. IL-4 and IL-13 share many functional properties as a result of their utilization of a common receptor complex comprising IL-13Ralpha1 (IL-13 receptor ...
Donna E. Davies, Holgate, Stephen T, Isabelle Kirby, Ida Karin Nordgren, Tavassoli, Ali, Davies, Donna E, Holloway, John W, Andrews, Allison-Lynn, Stephen T. Holgate, Nordgren, Ida Karin, John W. Holloway, Kirby, Isabelle, Allison-Lynn Andrews, Ali Tavassoli   +13 more
core   +1 more source