Results 11 to 20 of about 69,683,828 (280)

Heterodimeric IL-15 in Cancer Immunotherapy [PDF]

Cancers, 2021
Immunotherapy has emerged as a valuable strategy for the treatment of many cancer types. Interleukin-15 (IL-15) promotes the growth and function of cytotoxic CD8+ T and natural killer (NK) cells. It also enhances leukocyte trafficking and stimulates tumor-infiltrating lymphocytes expansion and activity.
Cristina Bergamaschi, Vasiliki Stravokefalou, Dimitris Stellas, Sevasti Karaliota, Barbara K. Felber, George N. Pavlakis   +5 more
openaire   +3 more sources

Regulation of IL-15 secretion via the leader peptide of two IL-15 isoforms

The Journal of Immunology, 1997
Abstract The secretion of IL-15, a potent modulator of T, B, and NK lymphocyte functions, is likely to be tightly controlled. Here, we show that human T lymphoblasts transcribe the IL-15 gene and generate an alternative splicing product that codes for the same amino acid composition as the mature IL-15 protein, but produces an IL-15 ...
Onu, A, Pohl, T, Krause, H, Bulfone-Paus, S   +3 more
core   +9 more sources

A Self-Activating IL-15 Chimeric Cytokine Receptor to Empower Cancer Immunotherapy [PDF]

ImmunoTargets and Therapy
Sumei Chen,1,* Lingrong Yang,2,* Bing Xia,3 Haitao Zhu,4 Zhenghao Piao,5 Youssef Jounaidi6 1Department of Radiation Oncology, Hangzhou Cancer Hospital, Hangzhou, Zhejiang, 310002, People’s Republic of China; 2Department of Hangzhou Cancer ...
Chen S, Yang L, Xia B, Zhu H, Piao Z, Jounaidi Y   +5 more
doaj   +1 more source

IL-15 [PDF]

Science-Business eXchange, 2014
Cardiovascular disease is the leading cause of death in Western countries. A major limitation of current treatments is the inability to efficiently repair or replace dead myocardium. Recently, stem cell-based therapies have been explored as an avenue to circumvent current therapeutic limitations.
Yeghiazarians, Yerem, Honbo, Norman, Imhof, Isabella, Woods, Brandon, Aguilera, Vanessa, Ye, Jianqin, Boyle, Andrew J, Karliner, Joel S   +7 more
  +7 more sources

Expression of IL‐15 and IL‐15 Receptor Isoforms in Select Structures of Human Fetal Brain

Annals of the New York Academy of Sciences, 2002
Abstract: IL‐15, a key cytokine linking innate and acquired immunity, is expressed in many cell types and tissues. Recent data indicate constitutive expression of IL‐15 in human neural cell lines and tissues. The aim of the present study was to examine the expression patterns of mRNA encoding IL‐15 and IL‐15 receptor α (IL‐15Rα) isoforms in select ...
M, Kurowska, W, Rudnicka, D, Maślińska, W, Maśliński   +3 more
openaire   +3 more sources

INFLUENCE OF HOMEOSTATIC CYTOKINES – IL-7 AND IL-15 ON T-REGULATORY CELLS IN VITRO

Медицинская иммунология, 2021
Cytokines IL-7 and IL-15 are the most important humoral factors providing T-conventional cell pool reconstitution during homeostatic proliferation caused by lymphopenia.
D. V. Shevyrev, V. A. Kozlov
doaj   +1 more source

NK Cell IL-10 Production Requires IL-15 and IL-10 Driven STAT3 Activation

Frontiers in Immunology, 2019
Natural killer (NK) cells can produce IFNγ or IL-10 to regulate inflammation and immune responses but the factors driving NK cell IL-10 secretion are poorly-defined.
Sarah E. Clark, Kristina S. Burrack, Stephen C. Jameson, Sara E. Hamilton, Laurel L. Lenz   +4 more
doaj   +1 more source

Free IL-15 Is More Abundant Than IL-15 Complexed With Soluble IL-15 Receptor-α in Murine Serum: Implications for the Mechanism of IL-15 Secretion [PDF]

Endocrinology, 2016
Abstract IL-15 is a cytokine that is part of the innate immune system, as well as a proposed myokine released from skeletal muscle during physical exercise that mediates many of the positive physiological effects of exercise. Many of the immune functions of IL-15 are mediated by juxtacrine signaling via externalized IL-15 bound to ...
Barbara G, Anderson, LeBris S, Quinn
openaire   +2 more sources

Oncolytic Effects of a Novel Influenza A Virus Expressing Interleukin-15 from the NS Reading Frame [PDF]

, 2012
Oncolytic influenza A viruses with deleted NS1 gene (delNS1) replicate selectively in tumour cells with defective interferon response and/or activated Ras/Raf/MEK/ERK signalling pathway.
Martin Michaelis, Muster Thomas, Joachim Seipelt, Markus Wolschek (167359), Martin Michaelis (23843), Marijke van Rikxoort (167355), Doerr, Hans Wilhelm, Wolschek Markus, Seipelt Joachim, Hans Wilhelm Doerr (17928), Andrej Egorov (167364), Thomas Muster, Hans Wilhelm Doerr, Jindrich Cinatl, Thomas Muster (167361), Muster, Thomas, Doerr Hans Wilhelm, Seipelt, Joachim, Joachim Seipelt (30928), Egorov Andrej, Cinatl Jindrich, Michaelis, Martin, Cinatl, Jindrich, Egorov, Andrej, Markus Wolschek, van Rikxoort, Marijke, Rikxoort, Marijke van, Andrej Egorov, van Rikxoort Marijke, Jindrich Cinatl Jr (167368), Wolschek, Markus, Marijke van Rikxoort, Michaelis Martin   +32 more
core   +2 more sources

An activation-induced IL-15 isoform is a natural antagonist for IL-15 function [PDF]

Scientific Reports, 2016
AbstractInterleukin 15 (IL-15) expression induces the secretion of inflammatory cytokines, inhibits the apoptosis of activated T cells and prolongs the survival of CD8+ memory T cells. Here we identified an IL-15 isoform lacking exon-6, IL-15ΔE6, generated by alternative splicing events of activated immune cells, including macrophages and B cells.
Zhao, L, Hu, B, Zhang, Y, Song, Y, Lin, D, Liu, Y, Mei, Y, Sandikin, D, Sun, W, Zhuang, M, Liu, H   +10 more
openaire   +2 more sources