Results 1 to 10 of about 80,028,732 (285)

Aberrant plasma IL-7 and soluble IL-7 receptor levels indicate impaired T-cell response to IL-7 in human tuberculosis. [PDF]

PLoS Pathogens, 2017
T-cell proliferation and generation of protective memory during chronic infections depend on Interleukin-7 (IL-7) availability and receptivity. Regulation of IL-7 receptor (IL-7R) expression and signalling are key for IL-7-modulated T-cell functions ...
Christian Lundtoft, Anthony Afum-Adjei Awuah, Jens Rimpler, Kirstin Harling, Norman Nausch, Malte Kohns, Ernest Adankwah, Franziska Lang, Laura Olbrich, Ertan Mayatepek, Ellis Owusu-Dabo, Marc Jacobsen   +11 more
doaj   +5 more sources

A mechanistically novel peptide agonist of the IL-7 receptor that addresses limitations of IL-7 cytokine therapy. [PDF]

PLoS ONE, 2023
Interleukin (IL)-7 is broadly active on T-cell populations, and modified versions have been clinically evaluated for a variety of therapeutic applications, including cancer, lymphopenia, and infectious diseases; and found to be relatively well-tolerated ...
William J Dower, Angie Inkyung Park, Alice V Bakker, Steven E Cwirla, Praechompoo Pongtornpipat, Blake M Williams, Prarthana Joshi, Bryan A Baxter, Michael C Needels, Ronald W Barrett   +9 more
doaj   +4 more sources

Empowerment of CAR-T Cells by IL-7 and IL-15 Boosts Their Efficacy Against HER2-Positive Tumors with Enhanced Expansion and Persistence [PDF]

Cells
Chimeric antigen receptor (CAR)-T cell therapy has achieved remarkable clinical success in B cell malignancies. However, its efficacy in solid tumors remains limited, in part due to suboptimal expansion, persistence, and restrained effector function ...
Zhehong Cheng, Henning Kirchgessner, Beate Jahraus, Emre Balta, Yvonne Samstag   +4 more
doaj   +2 more sources

A comprehensive review and meta-analysis of the relationships between interleukin-7 levels and COVID-19 severity [PDF]

Journal of Health and Social Sciences, 2023
Introduction: As the major mechanism for coronavirus disease 2019, cytokine storm-mediated organ harm continues to dominate current understanding. Despite the first hyper-inflammatory phase, emerging data show that virus-induced poor host immunity may be
Michal MATUSZEWSKI, Michal PRUC, Lukasz SZARPAK, Alla NAVOLOKINA, Katarzyna KIEZUN, Francesco CHIRICO, Gabriella NUCERA, Yuriy STEPANOVSKYY, Murat YILDIRIM, Anna HILFANOVA, Anastasia BONDARENKO   +10 more
doaj   +1 more source

PROPORTION OF NAIVE CD45RA+ AND CD31+T-CELLS IN PATIENTS WITH RHEUMATOID ARTHRITIS UNDER STIMULATION WITH HOMEOSTATIC FACTORS IN VITRO

Медицинская иммунология, 2021
Much attention of researchers is directed to study the role of factors of homeostatic proliferation in the pathogenesis of autoimmune diseases, however, the effect of IL-7 and IL-15 on the phenotype of naive T cells  has not yet been sufficiently ...
E. A. Blinova, L. V. Grishina, A. E. Sizkov, V. A. Kozlov   +3 more
doaj   +1 more source

INFLUENCE OF HOMEOSTATIC CYTOKINES – IL-7 AND IL-15 ON T-REGULATORY CELLS IN VITRO

Медицинская иммунология, 2021
Cytokines IL-7 and IL-15 are the most important humoral factors providing T-conventional cell pool reconstitution during homeostatic proliferation caused by lymphopenia.
D. V. Shevyrev, V. A. Kozlov
doaj   +1 more source

In vitro maintaining of CD4+ central and effector memory cells in normal and inflammatory conditions

Медицинская иммунология, 2020
IL-7 is a key factor for the survival and maintenance of CD4+ central (Tcm) and effector (Tem) memory cells in the whole body. In many autoimmune diseases, an elevated level of IL-7 is detected in blood serum and at the site of inflammation, thus ...
E. A. Blinova, A. V. Kolerova, V. E. Balyasnikov, V. A. Kozlov   +3 more
doaj   +1 more source

Atovaquone attenuates experimental colitis by reducing neutrophil infiltration of colonic mucosa

Frontiers in Pharmacology, 2022
Ulcerative colitis (UC) is a chronic relapsing disease featuring aberrant accumulation of neutrophils in colonic mucosa and the luminal space. Although significant advances in UC therapy have been made with the development of novel biologics and small ...
Laura D. Manzanares, Joseph David, Xingsheng Ren, Lenore K. Yalom, Enzo B. Piccolo, Yalda Dehghan, Aidan J. David, Stephen B. Hanauer, Ronen Sumagin   +8 more
doaj   +1 more source

IMMUNE PARAMETERS IN PATIENTS WITH BREAST CANCER AFTER RADIOTHERAPY AND SURGICAL TREATMENT

Медицинская иммунология, 2014
. Some immune parameters (cell subsets in peripheral blood, spontaneous and LPS-induce production of IL-1β, IL-5, IL-7, IL-12, IL-13, IL-17, G-CSF, MCP-1 and MIP-1β in whole blood cultures) were studied in fifty patients with breast cancer (T2-3, N0-3 ...
Yu. B. Selikhova, I. B. Ostanina, N. M. Starostina, S. V. Sidorov, E. V. Menyaeva, V. S. Kozhevnikov, E. R. Chernykh, A. A. Ostanin, V. A. Kozlov   +8 more
doaj   +1 more source

IL‐7 is expressed in malignant mesothelioma and has a prognostic value

Molecular Oncology, 2022
Malignant pleural mesothelioma (MPM) is an aggressive cancer mainly related to asbestos exposure. Despite recent therapeutic advances, notably immunotherapies, the benefit remains limited and restricted to a small percentage of patients.
Hoa‐Le Mai, Sophie Deshayes, Thi‐Van‐Ha Nguyen, Virginie Dehame, Anne‐Laure Chéné, Sophie Brouard, Christophe Blanquart   +6 more
doaj   +1 more source